{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:06:12Z","timestamp":1793361972755,"version":"4.5.0"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA127817"],"award-info":[{"award-number":["R01CA127817"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006732","name":"New York University","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100006732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci?n y Universidades","doi-asserted-by":"publisher","award":["PID2020-117116RB-I00"],"award-info":[{"award-number":["PID2020-117116RB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Magnesium\u00ad(II) plays catalytic, structural, regulatory, and signaling roles in living organisms. Abnormal levels of this metal have been associated with numerous pathologies, including cardiovascular disease, diabetes, metabolic syndrome, immunodeficiency, cancer, and, most recently, liver pathologies affecting humans. The role of Mg2+ in the pathophysiology of liver disease, however, has been occluded by concomitant changes in concentration of interfering divalent cations, such as Ca2+, which complicates the interpretation of experiments conducted with existing molecular Mg2+ indicators. Herein, we introduce a new quinoline-based fluorescent sensor, MagZet1, that displays a shift in its excitation and emission wavelengths, affording ratiometric detection of cellular Mg2+ by both fluorescence microscopy and flow cytometry. The new sensor binds the target metal with a submillimolar dissociation constant\ue5f8well suited for detection of changes in free Mg2+ in cells\ue5f8and displays a 10-fold selectivity against Ca2+. Furthermore, the fluorescence ratio is insensitive to changes in pH in the physiological range, providing an overall superior performance over existing indicators. We provide insights into the metal selectivity profile of the new sensor based on computational modeling, and we apply it to shed light on a decrease in cytosolic free Mg2+ and altered expression of metal transporters in cellular models of drug-induced liver injury caused by acetaminophen overdose.<\/jats:p>","DOI":"10.1021\/jacs.3c05704","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:32:30Z","timestamp":1696260750000},"page":"21841-21850","source":"Crossref","is-referenced-by-count":37,"title":["Ratiometric Fluorescent\nSensors Illuminate Cellular\nMagnesium Imbalance in a Model of Acetaminophen-Induced Liver Injury"],"prefix":"10.1021","volume":"145","author":[{"given":"Michael","family":"Brady","sequence":"first","affiliation":[{"name":"New York University , , , ,","place":["New York, New York, United States, 10003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika I.","family":"Shchepetkina","sequence":"additional","affiliation":[{"name":"New York University , , , ,","place":["New York, New York, United States, 10003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gonza\u0301lez-Recio","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) , Bizkaia Technology Park, Building 801A , ,","place":["Derio, Spain, 48160"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u0301a L.","family":"Marti\u0301nez-Chantar","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) , Bizkaia Technology Park, Building 801A , ,","place":["Derio, Spain, 48160"]},{"name":"Carlos III National Health Institute , , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2266-9026","authenticated-orcid":true,"given":"Daniela","family":"Buccella","sequence":"additional","affiliation":[{"name":"New York University , , , ,","place":["New York, New York, United States, 10003"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"issue":"1","key":"2026081707184936000_cit1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.00012.2014","article-title":"Magnesium in\nMan: Implications for Health and Disease","volume":"95","author":"de\nBaaij","year":"2015","journal-title":"Physiol.\nRev."},{"key":"2026081707184936000_cit2","first-page":"1","article-title":"Introduction\nto the Biological Chemistry of Magnesium Ion","volume-title":"The Biological Chemistry of Magnesium","author":"Cowan","year":"1995"},{"issue":"4","key":"2026081707184936000_cit3","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.3390\/nu13041136","article-title":"Magnesium: Biochemistry,\nNutrition, Detection, and Social Impact of Diseases Linked to Its\nDeficiency","volume":"13","author":"Fiorentini","year":"2021","journal-title":"Nutrients"},{"issue":"2","key":"2026081707184936000_cit4","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3390\/nu10020168","article-title":"Dietary Magnesium\nand Cardiovascular Disease: A Review with Emphasis in Epidemiological\nStudies","volume":"10","author":"Rosique-Esteban","year":"2018","journal-title":"Nutrients"},{"issue":"1\u20133","key":"2026081707184936000_cit5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0098-2997(02)00095-X","article-title":"Low\nMagnesium and Atherosclerosis: An Evidence-Based Link","volume":"24","author":"Maier","year":"2003","journal-title":"Mol. Aspects Med."},{"issue":"1","key":"2026081707184936000_cit6","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.abb.2006.05.007","article-title":"Magnesium\nMetabolism in Type 2 Diabetes Mellitus, Metabolic\nSyndrome and Insulin Resistance","volume":"458","author":"Barbagallo","year":"2007","journal-title":"Arch. Biochem.\nBiophys."},{"key":"2026081707184936000_cit7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-94-007-7500-8_3","article-title":"Magnesium\nin Health and Disease","volume-title":"Interrelations between\nEssential Metal Ions and Human Diseases","author":"Romani","year":"2013"},{"issue":"1","key":"2026081707184936000_cit8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.abb.2006.02.016","article-title":"Magnesium\nand Neoplasia: From Carcinogenesis to Tumor Growth and Progression\nor Treatment","volume":"458","author":"Wolf","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"issue":"7","key":"2026081707184936000_cit9","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1042\/CS20120086","article-title":"Magnesium\nand Its Transporters in Cancer: A Novel Paradigm\nin Tumour Development","volume":"123","author":"Wolf","year":"2012","journal-title":"Clin. Sci."},{"issue":"20","key":"2026081707184936000_cit10","doi-asserted-by":"publisher","first-page":"578","DOI":"10.21037\/atm.2019.09.70","article-title":"Magnesium\nand Liver Disease","volume":"7","author":"Liu","year":"2019","journal-title":"Ann. Transl. Med."},{"issue":"4","key":"2026081707184936000_cit11","first-page":"197","article-title":"Magnesium\nHomeostasis and Alcohol Consumption","volume":"21","author":"Romani","year":"2008","journal-title":"Magnes.\nRes."},{"issue":"1","key":"2026081707184936000_cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18076-5","article-title":"Magnesium Intake and\nMortality Due to Liver Diseases:\nResults from the Third National Health and Nutrition Examination Survey\nCohort","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"2026081707184936000_cit13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003983","article-title":"Basolateral\nMg2+ Extrusion via CNNM4 Mediates\nTranscellular Mg2+ Transport across Epithelia: A Mouse\nModel","volume":"9","author":"Yamazaki","year":"2013","journal-title":"PLoS Genet."},{"issue":"5","key":"2026081707184936000_cit14","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.3390\/ijms20051135","article-title":"Current\nStructural Knowledge on the\nCNNM Family of Magnesium Transport Mediators","volume":"20","author":"Gime\u0301nez-Mascarell","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026081707184936000_cit15","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jhep.2021.01.043","article-title":"Magnesium Accumulation Upon Cyclin M4 Silencing Activates Microsomal\nTriglyceride Transfer Protein Improving NASH","volume":"75","author":"Simo\u0301n","year":"2021","journal-title":"J. Hepatol."},{"issue":"1","key":"2026081707184936000_cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34262-0","article-title":"Restoring Cellular Magnesium Balance through\nCyclin M4 Protects against Acetaminophen-Induced Liver Damage","volume":"13","author":"Gonza\u0301lez-Recio","year":"2022","journal-title":"Nat. Commun."},{"key":"2026081707184936000_cit17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2147\/JIR.S136742","article-title":"Magnesium\nDeficiency and Increased Inflammation: Current Perspectives","volume":"Volume 11","author":"Nielsen","year":"2018","journal-title":"J. Inflamm. Res."},{"issue":"2","key":"2026081707184936000_cit18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0925-4439(00)00018-1","article-title":"Inflammatory\nResponse Following Acute Magnesium Deficiency in the Rat","volume":"1501","author":"Malpuech-Bruge\u0300re","year":"2000","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"11","key":"2026081707184936000_cit19","doi-asserted-by":"publisher","first-page":"4041","DOI":"10.1021\/bi00411a021","article-title":"Measurement of Cytosolic\nFree Magnesium Ion Concentration by Fluorine-19 NMR","volume":"27","author":"Levy","year":"1988","journal-title":"Biochemistry"},{"issue":"8","key":"2026081707184936000_cit20","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1039\/c0an00087f","article-title":"Intracellular Magnesium Detection: Imaging a Brighter\nFuture","volume":"135","author":"Trapani","year":"2010","journal-title":"Analyst"},{"issue":"23","key":"2026081707184936000_cit21","doi-asserted-by":"publisher","first-page":"12573","DOI":"10.1039\/C8RA00946E","article-title":"Fluorescent Probes for the Detection\nof Magnesium Ions (Mg2+): From Design to Application","volume":"8","author":"Liu","year":"2018","journal-title":"RSC Adv."},{"issue":"31","key":"2026081707184936000_cit22","doi-asserted-by":"publisher","first-page":"12458","DOI":"10.1039\/C6DT01557C","article-title":"Structural and Spectroscopic\nInsight into the Metal Binding Properties of the o-Aminophenol-N,N,O-Triacetic Acid (APTRA) Chelator:\nImplications for Design of Metal Indicators","volume":"45","author":"Brady","year":"2016","journal-title":"Dalton Trans."},{"issue":"50","key":"2026081707184936000_cit23","doi-asserted-by":"publisher","first-page":"16353","DOI":"10.1021\/ja049624l","article-title":"Design and\nSynthesis of Highly Sensitive and Selective Fluorescein-Derived Magnesium\nFluorescent Probes and Application to Intracellular 3D Mg2+ Imaging","volume":"126","author":"Komatsu","year":"2004","journal-title":"J. Am. Chem. Soc."},{"issue":"8","key":"2026081707184936000_cit24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023684","article-title":"Newly Developed\nMg2+-Selective\nFluorescent Probe Enables Visualization of Mg2+ Dynamics\nin Mitochondria","volume":"6","author":"Shindo","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"2026081707184936000_cit25","doi-asserted-by":"publisher","first-page":"3204","DOI":"10.1021\/ic5000606","article-title":"Formation of Ternary\nComplexes with MgATP: Effects on the Detection of Mg2+ in\nBiological Samples by Bidentate Fluorescent Sensors","volume":"53","author":"Schwartz","year":"2014","journal-title":"Inorg. Chem."},{"issue":"77","key":"2026081707184936000_cit26","doi-asserted-by":"publisher","first-page":"10644","DOI":"10.1039\/C7CC06141B","article-title":"Highly Selective Tridentate\nFluorescent Probes for Visualizing Intracellular Mg2+ Dynamics\nwithout Interference from Ca2+ Fluctuation","volume":"53","author":"Matsui","year":"2017","journal-title":"Chem. Commun."},{"issue":"1","key":"2026081707184936000_cit27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1246\/cl.170918","article-title":"Ratiometric\nImaging of Intracellular\nMg2+ Dynamics Using a Red Fluorescent Turn-off Probe and\na Green Fluorescent Turn-on Probe","volume":"47","author":"Matsui","year":"2018","journal-title":"Chem. Lett."},{"key":"2026081707184936000_cit28","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1007\/s10895-010-0644-y","article-title":"The Concept\nof \u03bb-Ratiometry in Fluorescence Sensing and Imaging","volume":"20","author":"Demchenko","year":"2010","journal-title":"J. Fluoresc."},{"issue":"1","key":"2026081707184936000_cit29","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0010-8545(00)00246-0","article-title":"Design Principles of Fluorescent\nMolecular Sensors for Cation Recognition","volume":"205","author":"Valeur","year":"2000","journal-title":"Coord.\nChem. Rev."},{"issue":"4","key":"2026081707184936000_cit30","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1039\/c2cs35363f","article-title":"Metal Coordination in Photoluminescent\nSensing","volume":"42","author":"Liu","year":"2013","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"2026081707184936000_cit32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.abb.2011.05.010","article-title":"Cellular\nMagnesium Homeostasis","volume":"512","author":"Romani","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"2026081707184936000_cit33","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/1011-1344(88)85081-4","article-title":"International\nUnion of Pure and Applied Chemistry Organic Chemistry Division Commission\non Photochemistry. Reference Materials for Fluorescence Measurement","volume":"2","author":"Eaton","year":"1988","journal-title":"J. Photochem. Photobiol., B"},{"issue":"10","key":"2026081707184936000_cit34","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1021\/cr940745l","article-title":"Structural Changes Accompanying Intramolecular\nElectron Transfer: Focus on Twisted Intramolecular Charge-Transfer\nStates and Structures","volume":"103","author":"Grabowski","year":"2003","journal-title":"Chem. Rev."},{"issue":"3","key":"2026081707184936000_cit35","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/nmeth.3256","article-title":"A General\nMethod to\nImprove Fluorophores for Live-Cell and Single-Molecule Microscopy","volume":"12","author":"Grimm","year":"2015","journal-title":"Nat. Methods"},{"issue":"11","key":"2026081707184936000_cit36","doi-asserted-by":"publisher","first-page":"4413","DOI":"10.1021\/acs.orglett.0c01414","article-title":"Azetidine-Containing Heterospirocycles Enhance the Performance of\nFluorophores","volume":"22","author":"Zhou","year":"2020","journal-title":"Org. Lett."},{"issue":"2","key":"2026081707184936000_cit37","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1039\/C4MT00230J","article-title":"Analyzing\nFree Zinc\u00ad(II) Ion Concentrations in Cell Biology with Fluorescent\nChelating Molecules","volume":"7","author":"Maret","year":"2015","journal-title":"Metallomics"},{"issue":"1","key":"2026081707184936000_cit38","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0165-022X(93)90065-V","article-title":"Measurement\nof Free Zn2+ Ion Concentration with the Fluorescent Probe\nMag-Fura-2 (FURAPTRA)","volume":"27","author":"Simons","year":"1993","journal-title":"J. Biochem. Biophys.\nMethods"},{"issue":"24","key":"2026081707184936000_cit39","doi-asserted-by":"publisher","first-page":"9554","DOI":"10.1523\/JNEUROSCI.17-24-09554.1997","article-title":"Measurement of Intracellular\nFree\nZinc in Living Cortical Neurons: Routes of Entry","volume":"17","author":"Sensi","year":"1997","journal-title":"J. Neurosci."},{"issue":"1","key":"2026081707184936000_cit40","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00214-007-0310-x","article-title":"The M06 Suite of\nDensity Functionals for Main Group\nThermochemistry, Thermochemical Kinetics, Noncovalent Interactions,\nExcited States, and Transition Elements: Two New Functionals and Systematic\nTesting of Four M06-Class Functionals and 12 Other Functionals","volume":"120","author":"Zhao","year":"2008","journal-title":"Theor. Chem. Acc."},{"issue":"7","key":"2026081707184936000_cit41","doi-asserted-by":"publisher","first-page":"m1850","DOI":"10.1107\/S1600536807027687","article-title":"Diaquabis\u00ad(Quinoline-2-Carboxylato-k2N,O)\u00adMagnesium\u00ad(II)\nDihydrate Methanol Disolvate","volume":"E63","author":"Tai","year":"2007","journal-title":"Acta Crystallogr."},{"issue":"Pt 2","key":"2026081707184936000_cit42","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1107\/S2052520616003954","article-title":"The Cambridge Structural\nDatabase","volume":"72","author":"Groom","year":"2016","journal-title":"Acta Crystallogr."},{"issue":"11","key":"2026081707184936000_cit43","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.1107\/S0567740877011054","article-title":"Calcium\nBinding to \u03b1-Amino\nAcids: The Crystal Structure of Calcium L-Glutamate Chloride Monohydrate","volume":"33","author":"Einspahr","year":"1977","journal-title":"Acta Crystallogr., Sect. B: Struct. Sci., Cryst. Eng. Mater."},{"issue":"5","key":"2026081707184936000_cit44","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1107\/S0567740881005037","article-title":"The Geometry of Calcium-Carboxylate Interactions in\nCrystalline Complexes","volume":"37","author":"Einspahr","year":"1981","journal-title":"Acta Crystallogr., Sect.\nB: Struct. Sci."},{"issue":"12","key":"2026081707184936000_cit45","doi-asserted-by":"publisher","first-page":"6803","DOI":"10.1073\/pnas.95.12.6803","article-title":"Measurement\nof Cytosolic, Mitochondrial, and Golgi pH in Single Living Cells with\nGreen Fluorescent Proteins","volume":"95","author":"Llopis","year":"1998","journal-title":"Proc. Natl. Acad.\nSci. U.S.A."},{"issue":"1","key":"2026081707184936000_cit46","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/0006-291X(83)91562-0","article-title":"Measurement of the\nDissociation Constant of MgATP at Physiological Nucleotide Levels\nby a Combination of 31P NMR and Optical Absorbance Spectroscopy","volume":"117","author":"Gupta","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5806","key":"2026081707184936000_cit47","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/290527a0","article-title":"A Non-Disruptive\nTechnique for Loading Calcium Buffers and Indicators into Cells","volume":"290","author":"Tsien","year":"1981","journal-title":"Nature"},{"issue":"1","key":"2026081707184936000_cit48","doi-asserted-by":"publisher","first-page":"H281","DOI":"10.1152\/ajpheart.1993.265.1.H281","article-title":"Dynamics\nof Intracellular Free Mg2+ Changes in a Vascular Smooth\nMuscle Cell Line","volume":"265","author":"Quamme","year":"1993","journal-title":"Am. J. Physiol. Heart Circ.\nPhysiol."},{"key":"2026081707184936000_cit49","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1113\/jphysiol.1980.sp013346","article-title":"Magnesium Buffering\nin Intact Human Red Blood Cells\nMeasured Using the Ionophore A23187","volume":"305","author":"Flatman","year":"1980","journal-title":"J. Physiol."},{"issue":"2","key":"2026081707184936000_cit50","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0003-2697(85)90550-0","article-title":"Bromo-A23187:\nA Nonfluorescent Calcium Ionophore for Use with Fluorescent Probes","volume":"146","author":"Deber","year":"1985","journal-title":"Anal. Biochem."},{"issue":"6","key":"2026081707184936000_cit51","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1039\/c3mt00103b","article-title":"Tris\u00ad(2-Pyridylmethyl)\u00adAmine\n(TPA) as a Membrane-Permeable Chelator for Interception of Biological\nMobile Zinc","volume":"5","author":"Huang","year":"2013","journal-title":"Metallomics"},{"key":"2026081707184936000_cit52","volume-title":"Handbook of Fluorescent\nProbes and Research Products","author":"Haugland","year":"2002"},{"issue":"2","key":"2026081707184936000_cit53","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1006\/abio.2000.4983","article-title":"Mag-Indo1 Affinity\nfor Ca2+, Compartmentalization and Binding to Proteins:\nThe Challenge of Measuring Mg2+ Concentrations in Living\nCells","volume":"290","author":"Pesco","year":"2001","journal-title":"Anal. Biochem."},{"issue":"6","key":"2026081707184936000_cit54","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1111\/j.1751-1097.1993.tb04972.x","article-title":"Proton, Mg2+ and Protein as Competing Ligands\nfor the Fluorescent Probe, Mag-Indo-1:\nA First Step to the Quantification of Intracellular Mg2+ Concentration","volume":"58","author":"Morelle","year":"1993","journal-title":"Photochem. Photobiol."},{"issue":"2","key":"2026081707184936000_cit55","doi-asserted-by":"publisher","first-page":"131","DOI":"10.14218\/JCTH.2015.00052","article-title":"Acetaminophen-Induced\nHepatotoxicity: A Comprehensive Update","volume":"4","author":"Yoon","year":"2016","journal-title":"J. Clin\nTransl. Hepatol."},{"key":"2026081707184936000_cit56","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3389\/fmed.2018.00192","article-title":"Calcium Signaling in Liver Injury\nand Regeneration","volume":"5","author":"Oliva-Vilarnau","year":"2018","journal-title":"Front Med."},{"issue":"2","key":"2026081707184936000_cit57","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1093\/toxsci\/kfh151","article-title":"Acetaminophen-Induced\nOxidant Stress and Cell Injury in Cultured Mouse Hepatocytes: Protection\nby N-Acetyl Cysteine","volume":"80","author":"Bajt","year":"2004","journal-title":"Toxicol. Sci."},{"key":"2026081707184936000_cit58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-1-4939-7677-5_8","article-title":"Use of Liver-Derived Cell Lines\nfor the Study of\nDrug-Induced Liver Injury","volume-title":"Drug-Induced\nLiver Toxicity","author":"Ren","year":"2018"},{"issue":"3","key":"2026081707184936000_cit59","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1124\/dmd.110.035873","article-title":"Similarities and Differences\nin the Expression of Drug-Metabolizing\nEnzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes","volume":"39","author":"Guo","year":"2011","journal-title":"Drug Metab. Dispos."},{"issue":"5","key":"2026081707184936000_cit60","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1085\/jgp.200609502","article-title":"Functional\nCharacterization of Homo-\nand Heteromeric Channel Kinases TRPM6 and TRPM7","volume":"127","author":"Li","year":"2006","journal-title":"J. Gen. 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