{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:57:41Z","timestamp":1793429861000,"version":"4.5.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"42","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H04450"],"award-info":[{"award-number":["JP19H04450"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H05051"],"award-info":[{"award-number":["JP22H05051"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000078","name":"Division of Materials Research","doi-asserted-by":"publisher","award":["DMR 1308363"],"award-info":[{"award-number":["DMR 1308363"]}],"id":[{"id":"10.13039\/100000078","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2023,10,25]]},"DOI":"10.1021\/jacs.3c06799","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:56:58Z","timestamp":1697464618000},"page":"23143-23151","source":"Crossref","is-referenced-by-count":32,"title":["Design of an Anti-HMGB1 Synthetic Antibody for\n                    <i>In Vivo<\/i>\n                    Ischemic\/Reperfusion Injury Therapy"],"prefix":"10.1021","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1763-6593","authenticated-orcid":true,"given":"Hiroyuki","family":"Koide","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Kiyokawa","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Okishima","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaito","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1428-0029","authenticated-orcid":true,"given":"Keiichi","family":"Yoshimatsu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Missouri State University, 901 South National Avenue, Springfield, Missouri 65897, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-8602","authenticated-orcid":true,"given":"Tatsuya","family":"Fukuta","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Kyushu University, 744 Motooka, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Kyushu University, 744 Motooka, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8590-6079","authenticated-orcid":true,"given":"Yoshiko","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Kyushu University, 744 Motooka, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Oku","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-0059","authenticated-orcid":true,"given":"Kenneth J.","family":"Shea","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California Irvine, Irvine, California 92697, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00190.x"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24903.001"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.3389\/fonc.2020.01182","volume":"10","author":"Yang E. Y.","year":"2020","journal-title":"Front. Oncol."},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c04182"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1955"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.06.052"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(02)00343-0"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/ja711193x"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00125"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21753-9"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC04169E"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202306274"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/prot.26280"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvv049"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj8754"},{"key":"ref16\/cit16","volume-title":"Chance and Necessity; an Essay on the Natural Philosophy of Modern Biology","author":"Monod J.","year":"1972"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00044"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2749"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107797"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00171"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006736"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.12.033"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25847-2"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.222"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306793200"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-8770com"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2435-08.2008"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600582"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3815-05.2006"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21555"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2749"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217311"},{"key":"ref33\/cit33","first-page":"101","volume":"4","author":"Martinotti S.","year":"2015","journal-title":"Immunotargets Ther."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.09.057"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ja303612d"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200900186"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.16.1113"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201806328"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.02.028"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200304135"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.12.033"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2226"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000126044.83777.f4"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2005.12.028"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3389\/fncel.2019.00127","volume":"13","author":"Ye Y.","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.600280"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0418-z"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-221325"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1081\/DDC-120001481"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.02.004"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c06799","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c06799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T05:05:07Z","timestamp":1698210307000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.3c06799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":50,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2023,10,25]]}},"alternative-id":["10.1021\/jacs.3c06799"],"URL":"https:\/\/doi.org\/10.1021\/jacs.3c06799","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,16]]}}}