{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T04:17:28Z","timestamp":1787113048938,"version":"build-2736575974"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H02757"],"award-info":[{"award-number":["JP20H02757"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sulfite reduction by dissimilatory sulfite reductases is a key process in the global sulfur cycle. Sulfite reductases catalyze the 6e\u2013 reduction of SO32\u2013 to H2S using eight protons (SO32\u2013 + 8H+ + 6e\u2013 \u2192 H2S + 3H2O). However, detailed research into the reductive conversion of sulfite on transition-metal-based complexes remains unexplored. As part of our ongoing research into reproducing the function of reductases using dinuclear ruthenium complex {(TpRu)2(\u03bc-Cl)\u00ad(\u03bc-pz)} (Tp = HB\u00ad(pyrazolyl)3), we have targeted the function of sulfite reductase. The isolation of a key SO-bridged complex, followed by a sulfite-bridged complex, eventually resulted in a stepwise sulfite reduction. The reduction of a sulfite to a sulfur monoxide using 4H+ and 4e\u2013, which was followed by conversion of the sulfur monoxide to a disulfide with concomitant consumption of 2H+ and 2e\u2013, proceeded on the same platform. Finally, the production of H2S from the disulfide-bridged complex was achieved.<\/jats:p>","DOI":"10.1021\/jacs.3c07248","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T08:47:33Z","timestamp":1693471653000},"page":"21729-21732","source":"Crossref","is-referenced-by-count":4,"title":["Stepwise\nSulfite Reduction on a Dinuclear Ruthenium\nComplex Leading to Hydrogen Sulfide"],"prefix":"10.1021","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-2340","authenticated-orcid":true,"given":"Yasuhiro","family":"Arikawa","sequence":"first","affiliation":[{"name":"Nagasaki University , , Bunkyo-machi 1-14 , ,","place":["Nagasaki, Japan, 852-8521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Nagasaki University , , Bunkyo-machi 1-14 , ,","place":["Nagasaki, Japan, 852-8521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuko","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Nagasaki University , , Bunkyo-machi 1-14 , ,","place":["Nagasaki, Japan, 852-8521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Nagaoka","sequence":"additional","affiliation":[{"name":"Nagasaki University , , Bunkyo-machi 1-14 , ,","place":["Nagasaki, Japan, 852-8521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Tsujita","sequence":"additional","affiliation":[{"name":"Nagasaki University , , Bunkyo-machi 1-14 , ,","place":["Nagasaki, Japan, 852-8521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-9752","authenticated-orcid":true,"given":"Taiji","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Kyushu University , , ,","place":["Fukuoka, Japan, 819-0395"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Kyushu University , , ,","place":["Fukuoka, Japan, 819-0395"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5692-6377","authenticated-orcid":true,"given":"Shinnosuke","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Nagasaki University , , Bunkyo-machi 1-14 , ,","place":["Nagasaki, Japan, 852-8521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9882-7628","authenticated-orcid":true,"given":"Eri","family":"Sakuda","sequence":"additional","affiliation":[{"name":"Nagasaki University , , Bunkyo-machi 1-14 , ,","place":["Nagasaki, Japan, 852-8521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6279-9722","authenticated-orcid":true,"given":"Kazunari","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Kyushu University , , ,","place":["Fukuoka, Japan, 819-0395"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2027-6333","authenticated-orcid":true,"given":"Keisuke","family":"Umakoshi","sequence":"additional","affiliation":[{"name":"Nagasaki University , , Bunkyo-machi 1-14 , ,","place":["Nagasaki, Japan, 852-8521"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"2026081707172927700_cit1a","first-page":"45","article-title":"Microbial Sulfite Respiration","volume-title":"Advances\nin Microbial Physiology","author":"Simon","year":"2013"},{"key":"2026081707172927700_cit1b","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.bej.2008.12.011","article-title":"Bacteria of the sulphur cycle: An\noverview of microbiology, biokinetics and their role in petroleum\nand mining industries","volume":"44","author":"Tang","year":"2009","journal-title":"Biochem. Eng. J."},{"key":"2026081707172927700_cit1c","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1128\/mmbr.61.4.503-532.1997","article-title":"Metabolism of sulfur amino acids\nin Saccharomyces cerevisiae","volume":"61","author":"Thomas","year":"1997","journal-title":"Microbiol. Mol.\nBiol. Rev."},{"key":"2026081707172927700_cit2a","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1126\/science.aad3558","article-title":"A protein trisulfide\ncouples dissimilatory sulfate reduction to energy conservation","volume":"350","author":"Santos","year":"2015","journal-title":"Science"},{"key":"2026081707172927700_cit2b","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/nature14109","article-title":"The octahaem\nMccA is a haem c\u2013copper sulfite reductase","volume":"520","author":"Hermann","year":"2015","journal-title":"Nature"},{"key":"2026081707172927700_cit2c","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.bbabio.2014.03.007","article-title":"The \u201cbacterial heterodisulfide\u201d\nDsrC is a key protein in dissimilatory sulfur metabolism","volume":"1837","author":"Venceslau","year":"2014","journal-title":"Biochim. Biophys. 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Chim. Acta"},{"key":"2026081707172927700_cit9e","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1021\/ic951518k","article-title":"Oxidation at a Dimolybdenum\u00ad(V) Sulfur Bridge. Formation\nof SO and SO2 Bridges. Facile Extrusion of SO from the\nSO2 Bridge","volume":"35","author":"Wang","year":"1996","journal-title":"Inorg. Chem."},{"key":"2026081707172927700_cit9f","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1039\/C39900001190","article-title":"A sulphur monoxide-bridged\ndinickel a-frame complex: [Ni2(\u03bc-SO)\u00ad(PPh2CH2PPh2)2Cl2]","author":"Gong","year":"1990","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"2026081707172927700_cit9g","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.1021\/ic00268a041","article-title":"Reaction of hydrogen sulfide with\ndinuclear palladium\u00ad(I) complexes containing bis\u00ad(diphenylphosphino)\nmethane (dpm) and conversion of bridged-sulfide derivatives to bridged-sulfoxide\nspecies. X-ray crystal structure of the dimetallic sulfoxide Pd2Cl2(\u03bc-SO)\u00ad(\u03bc-dpm)2 containing\npyramidal sulfur","volume":"26","author":"Besenyei","year":"1987","journal-title":"Inorg. Chem."},{"key":"2026081707172927700_cit9h","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/anie.198502281","article-title":"Sulfur Monoxide\nas 4-Electron Bridge-Ligand in the Complex [{(\u03b75-C5H5)\u00ad(CO)2Mn}2SO]","volume":"24","author":"Lorenz","year":"1985","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081707172927700_cit9i","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1039\/C39850001024","article-title":"Stepwise metal-promoted\nconversion of \u03b72-CS2 into \u03b72-SO. Synthesis and crystal structure of the complex [(triphos)\u00adRh\u00ad(\u03bc-SO)2Rh\u00ad(triphos)]\u00ad[BPh4]2\u2022HCONMe2 [triphos = MeC\u00ad(CH2PPh2)3]","author":"Bianchini","year":"1985","journal-title":"J. Chem. Soc., Chem. 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Chem."},{"key":"2026081707172927700_cit11b","doi-asserted-by":"publisher","first-page":"15330","DOI":"10.1021\/jacs.5b10675","article-title":"Mechanistic Insights into the H2S-Mediated Reduction of Aryl Azides Commonly Used in H2S Detection","volume":"137","author":"Henthorn","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"2026081707172927700_cit11c","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1039\/C2AN36113B","article-title":"Fluorescent\nprobe for highly selective and sensitive detection of hydrogen sulfide\nin living cells and cardiac tissues","volume":"138","author":"Chen","year":"2013","journal-title":"Analyst"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c07248","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/145\/40\/21729\/3966858\/ja3c07248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/145\/40\/21729\/3966858\/ja3c07248.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:32:22Z","timestamp":1786966342000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/145\/40\/21729\/400668\/Stepwise-Sulfite-Reduction-on-a-Dinuclear"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,31]]},"references-count":35,"journal-issue":{"issue":"40","published-online":{"date-parts":[[2023,8,31]]},"published-print":{"date-parts":[[2023,10,11]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.3c07248","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,31]]}}}