{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:25:22Z","timestamp":1786969522193,"version":"build-2736575974"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21721005"],"award-info":[{"award-number":["21721005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277091"],"award-info":[{"award-number":["22277091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92153303"],"award-info":[{"award-number":["92153303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>N 4-Acetylcytidine (ac4C) has been found to affect a variety of cellular and biological processes. For a mechanistic understanding of the roles of ac4C in biology and disease, we present an antibody-free, fluorine-assisted metabolic sequencing method to detect RNA ac4C, called \u201cFAM-seq\u201d. We successfully applied FAM-seq to profile ac4C landscapes in human 293T, HeLa, and MDA cell lines in parallel with the reported acRIP-seq method. By comparison with the classic ac4C antibody sequencing method, we found that FAM-seq is a convenient and reliable method for transcriptome-wide mapping of ac4C. Because this method holds promise for detecting nascent RNA ac4C modifications, we further investigated the role of ac4C in regulating chemotherapy drug resistance in chronic myeloid leukemia. The results indicated that drug development or combination therapy could be enhanced by appreciating the key role of ac4C modification in cancer therapy.<\/jats:p>","DOI":"10.1021\/jacs.3c08483","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:30:21Z","timestamp":1695979821000},"page":"22232-22242","source":"Crossref","is-referenced-by-count":29,"title":["Antibody-Free Fluorine-Assisted\nMetabolic Sequencing\nof RNA\n                    <i>N<\/i>\n                    4\u2011Acetylcytidine"],"prefix":"10.1021","volume":"145","author":[{"given":"Shen","family":"Yan","sequence":"first","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziang","family":"Lu","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2240-4001","authenticated-orcid":true,"given":"Jinglei","family":"Xu","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2281-1763","authenticated-orcid":true,"given":"Yafen","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linao","family":"Ren","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wei","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-6078","authenticated-orcid":true,"given":"Song-mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Feng","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5223-4659","authenticated-orcid":true,"given":"Bifeng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0605-8495","authenticated-orcid":true,"given":"Xiaocheng","family":"Weng","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-6733","authenticated-orcid":true,"given":"Yuhao","family":"Du","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-9368","authenticated-orcid":true,"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]},{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]},{"name":"Wuhan University , , , ,","place":["Wuhan, Hubei, PR China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"2026081707200160400_cit1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","article-title":"Modulation of cellular processes by histone and non-histone\nprotein acetylation","volume":"23","author":"Shvedunova","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026081707200160400_cit2","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1038\/2191363a0","article-title":"Structure\nof a mammalian serine tRNA","volume":"219","author":"Staehelin","year":"1968","journal-title":"Nature"},{"key":"2026081707200160400_cit3","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/S0021-9258(17)38117-6","article-title":"N4-Acetylcytidine. A previously unidentified\nlabile component of the small subunit of eukaryotic ribosomes","volume":"253","author":"Thomas","year":"1978","journal-title":"J. Biol. Chem."},{"key":"2026081707200160400_cit4","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1016\/j.cell.2018.10.030","article-title":"Acetylation\nof cytidine in mRNA promotes translation efficiency","volume":"175","author":"Arango","year":"2018","journal-title":"Cell"},{"key":"2026081707200160400_cit5","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/s41586-020-2418-2","article-title":"Dynamic RNA acetylation\nrevealed by quantitative cross-evolutionary mapping","volume":"583","author":"Sas-Chen","year":"2020","journal-title":"Nature"},{"key":"2026081707200160400_cit6","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1038\/s41596-021-00501-9","article-title":"Quantitative\nnucleotide resolution profiling of RNA cytidine acetylation by ac4C-seq","volume":"16","author":"Thalalla\nGamage","year":"2021","journal-title":"Nat. Protoc."},{"key":"2026081707200160400_cit7","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1016\/j.molcel.2022.05.016","article-title":"Direct epitranscriptomic\nregulation of mammalian translation\ninitiation through N4-acetylcytidine","volume":"82","author":"Arango","year":"2022","journal-title":"Mol. Cell."},{"key":"2026081707200160400_cit8","doi-asserted-by":"publisher","first-page":"26201","DOI":"10.1074\/jbc.M114.593996","article-title":"A single acetylation\nof 18S rRNA is essential for biogenesis of the small ribosomal subunit\nin Saccharomyces cerevisiae","volume":"289","author":"Ito","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2026081707200160400_cit9","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1093\/nar\/gkv075","article-title":"Yeast Kre33\nand human NAT10 are conserved\n18S rRNA cytosine acetyltransferases that modify tRNAs assisted by\nthe adaptor Tan1\/THUMPD1","volume":"43","author":"Sharma","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2026081707200160400_cit10","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1038\/s41589-018-0119-z","article-title":"Acetate-dependent tRNA\nacetylation required for decoding fidelity in protein synthesis","volume":"14","author":"Taniguchi","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"2026081707200160400_cit11","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1126\/science.1252651","article-title":"Chemical Inhibition of NAT10 Corrects Defects of Laminopathic\nCells","volume":"344","author":"Larrieu","year":"2014","journal-title":"Science"},{"key":"2026081707200160400_cit12","doi-asserted-by":"publisher","first-page":"113620","DOI":"10.1016\/j.yexcr.2023.113620","article-title":"NAT10-mediated AXL mRNA N4-acetylcytidine\nmodification promotes pancreatic carcinoma progression","volume":"428","author":"Zong","year":"2023","journal-title":"Exp. Cell Res."},{"key":"2026081707200160400_cit13","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300898","article-title":"N4-Acetylcytidine Drives Glycolysis\nAddiction in Gastric Cancer via NAT10\/SEPT9\/HIF-1\u03b1 Positive\nFeedback Loop","volume":"10","author":"Yang","year":"2023","journal-title":"Adv. Sci."},{"key":"2026081707200160400_cit14","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202106058","article-title":"PIWI-Interacting RNA\nHAAPIR Regulates Cardiomyocyte Death After Myocardial Infarction by\nPromoting NAT10-Mediated ac4C Acetylation of Tfec mRNA","volume":"9","author":"Wang","year":"2022","journal-title":"Adv. Sci."},{"key":"2026081707200160400_cit15","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41422-023-00793-4","article-title":"Lysine 2-hydroxyisobutyrylation\nof NAT10 promotes cancer metastasis in an ac4C-dependent manner","volume":"33","author":"Liao","year":"2023","journal-title":"Cell Res."},{"key":"2026081707200160400_cit16","doi-asserted-by":"publisher","first-page":"7791","DOI":"10.1021\/ja311636b","article-title":"Labeling lysine\nacetyltransferase substrates with engineered\nenzymes and functionalized cofactor surrogates","volume":"135","author":"Yang","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"2026081707200160400_cit17","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nchembio.1296","article-title":"Chemical reporters\nfor biological discovery","volume":"9","author":"Grammel","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"2026081707200160400_cit18","doi-asserted-by":"publisher","first-page":"4883","DOI":"10.1002\/anie.201300252","article-title":"A Chemical\nProbe for Lysine Malonylation","volume":"52","author":"Bao","year":"2013","journal-title":"Angew. Chem.,\nInt. Ed. Engl."},{"key":"2026081707200160400_cit19","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1002\/cbic.201200438","article-title":"Fluorescent DNA\nlabeling by N-mustard analogues of S-adenosyl-L-methionine","volume":"13","author":"Du","year":"2012","journal-title":"ChemBioChem"},{"key":"2026081707200160400_cit20","doi-asserted-by":"publisher","first-page":"5182","DOI":"10.1002\/anie.201608625","article-title":"Methyltransferase-Directed\nLabeling of Biomolecules\nand its Applications","volume":"56","author":"Deen","year":"2017","journal-title":"Angew. Chem., Int. Ed.\nEngl."},{"key":"2026081707200160400_cit21","doi-asserted-by":"publisher","first-page":"3486","DOI":"10.1021\/ja021106s","article-title":"Design of\na new fluorescent cofactor\nfor DNA methyltransferases and sequence-specific labeling of DNA","volume":"125","author":"Pljevaljcic","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"2026081707200160400_cit22","doi-asserted-by":"publisher","first-page":"6342","DOI":"10.1002\/anie.201800188","article-title":"Enzymatic\nor in vivo installation of propargyl groups\nin combination with click chemistry for the enrichment and detection\nof methyltransferase target sites in RNA","volume":"57","author":"Hartstock","year":"2018","journal-title":"Angew.\nChem., Int. Ed."},{"key":"2026081707200160400_cit23","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/s41589-020-0526-9","article-title":"A metabolic labeling method detects\nm6A transcriptome-wide at single base resolution","volume":"16","author":"Shu","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"2026081707200160400_cit24","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1038\/s41587-022-01243-z","article-title":"m6A RNA modifications\nare measured at single-base resolution across the mammalian transcriptome","volume":"40","author":"Hu","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"2026081707200160400_cit25","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cbpa.2014.10.020","article-title":"Chemical methods for the proteomewide identification\nof posttranslationally modified proteins","volume":"24","author":"Chuh","year":"2015","journal-title":"Curr.\nOpin. Chem. Biol."},{"key":"2026081707200160400_cit26","doi-asserted-by":"publisher","first-page":"3640","DOI":"10.1021\/ja908871t","article-title":"Bioorthogonal\nchemical reporters\nfor monitoring protein acetylation","volume":"132","author":"Yang","year":"2010","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026081707200160400_cit27","doi-asserted-by":"publisher","first-page":"12125","DOI":"10.1021\/ja002627n","article-title":"Contribution\nof fluorine to protein-ligand\naffinity in the binding of fluoroaromatic inhibitors to carbonic anhydrase\nII","volume":"122","author":"Kim","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"2026081707200160400_cit28","doi-asserted-by":"publisher","first-page":"16705","DOI":"10.1016\/S0021-9258(17)44813-7","article-title":"Enzyme inhibition by fluoro compounds","volume":"265","author":"Abeles","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2026081707200160400_cit29","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nmeth.2595","article-title":"Adding an unnatural covalent bond to proteins through proximity-enhanced\nbioreactivity","volume":"10","author":"Xiang","year":"2013","journal-title":"Nat. Methods"},{"key":"2026081707200160400_cit30","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1021\/jacs.0c05605","article-title":"Steric-Free Bioorthogonal\nLabeling of Acetylation Substrates Based on a Fluorine-Thiol Displacement\nReaction","volume":"143","author":"Lyu","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"2026081707200160400_cit31","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/s41467-022-27995-5","article-title":"Unprotected peptide macrocyclization and stapling via\na fluorine-thiol displacement reaction","volume":"13","author":"Islam","year":"2022","journal-title":"Nat.\nCommun."},{"key":"2026081707200160400_cit32","doi-asserted-by":"publisher","first-page":"9269","DOI":"10.1021\/bi101102u","article-title":"Structural\nand biochemical studies of a fluoroacetyl-CoA-specific thioesterase\nreveal a molecular basis for fluorine selectivity","volume":"49","author":"Weeks","year":"2010","journal-title":"Biochemistry"},{"key":"2026081707200160400_cit33","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/j.cell.2014.11.020","article-title":"Acetate\ndependence of tumors","volume":"159","author":"Comerford","year":"2014","journal-title":"Cell"},{"key":"2026081707200160400_cit34","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1073\/pnas.1614268114","article-title":"ACSS2-mediated\nacetyl-CoA synthesis from acetate is necessary for human cytomegalovirus\ninfection","volume":"114","author":"Vysochan","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026081707200160400_cit35","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.144156","article-title":"Gut-derived acetate\npromotes B10\ncells with antiinflammatory effects","volume":"6","author":"Dai\u0308en","year":"2021","journal-title":"JCI Insight"},{"key":"2026081707200160400_cit36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2014681118","article-title":"Butyrate enhances CPT1A\nactivity\nto promote fatty acid oxidation and iTreg differentiation","volume":"118","author":"Hao","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026081707200160400_cit37","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1038\/s42255-021-00479-4","article-title":"Pharmacological\ninhibition of fatty acid synthesis blocks SARS-CoV-2 replication","volume":"3","author":"Chu","year":"2021","journal-title":"Nat. Metab."},{"key":"2026081707200160400_cit38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13046-022-02586-w","article-title":"Helicobacter\npylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation\nto facilitate gastric cancer progression","volume":"42","author":"Deng","year":"2023","journal-title":"J.\nExp. Clin. Cancer Res."},{"key":"2026081707200160400_cit39","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s11010-020-03776-w","article-title":"Remodelin,\nan inhibitor of NAT10, could suppress hypoxia-induced or constitutional\nexpression of HIFs in cells","volume":"472","author":"Wu","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"2026081707200160400_cit40","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1186\/s13046-022-02551-7","article-title":"Acetyltransferase\nNAT10 regulates the Wnt\/\u03b2-catenin signaling pathway to promote\ncolorectal cancer progression via ac4C acetylation of KIF23 mRNA","volume":"41","author":"Jin","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"2026081707200160400_cit41","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1158\/0008-5472.CAN-22-2233","article-title":"NAT10 Drives\nCisplatin Chemoresistance by Enhancing ac4C-Associated DNA Repair\nin Bladder Cancer","volume":"83","author":"Xie","year":"2023","journal-title":"Cancer Res."},{"key":"2026081707200160400_cit42","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0002-9343(77)90124-3","article-title":"Chronic myelocytic\nleukemia: clonal\norigin in a stem cell common to the granulocyte, erythrocyte, platelet\nand monocyte\/macrophage","volume":"63","author":"Fialkow","year":"1977","journal-title":"Am. J. Med."},{"key":"2026081707200160400_cit43","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1002\/ajh.23282","article-title":"Chronic myeloid\nleukemia: 2012 update on diagnosis,\nmonitoring, and management","volume":"87","author":"Jabbour","year":"2012","journal-title":"Am. J. Hematol."},{"key":"2026081707200160400_cit44","doi-asserted-by":"publisher","first-page":"5988","DOI":"10.1021\/acs.jmedchem.8b00335","article-title":"Discovery\nof 5-cyano-6-phenylpyrimidin derivatives containing an acylurea moiety\nas orally bioavailable reversal agents against P-glycoprotein-mediated\nmutidrug resistance","volume":"61","author":"Wang","year":"2018","journal-title":"J. Med. Chem."},{"key":"2026081707200160400_cit45","doi-asserted-by":"publisher","first-page":"4123","DOI":"10.3390\/cancers14174123","article-title":"Recent\nTrends in Nanomedicine-Based Strategies to Overcome\nMultidrug Resistance in Tumors","volume":"14","author":"Khan","year":"2022","journal-title":"Cancers"},{"key":"2026081707200160400_cit46","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1002\/cac2.12363","article-title":"N-acetyltransferase\n10 promotes colon cancer progression by inhibiting ferroptosis through\nN4-acetylation and stabilization of ferroptosis suppressor protein\n1 (FSP1) mRNA","volume":"42","author":"Zheng","year":"2022","journal-title":"Cancer Commun."},{"key":"2026081707200160400_cit47","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.3233\/JAD-220564","article-title":"Comprehensive\nanalysis of long non-coding RNAs N4-acetylcytidine in Alzheimer\u2019s\ndisease mice model using high-throughput sequencing","volume":"90","author":"Ma","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"2026081707200160400_cit48","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s41392-022-01175-9","article-title":"RNA modifications:\nimportance in immune cell biology and related diseases","volume":"7","author":"Cui","year":"2022","journal-title":"Signal Transduction Targeted Ther."},{"key":"2026081707200160400_cit49","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.chom.2020.05.011","article-title":"Acetylation of Cytidine Residues Boosts HIV-1 Gene\nExpression by Increasing Viral RNA Stability","volume":"28","author":"Tsai","year":"2020","journal-title":"Cell Host Microbe"},{"key":"2026081707200160400_cit50","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1021\/acschembio.6b00776","article-title":"LSD1 Substrate Binding\nand Gene Expression Are Affected\nby HDAC1-Mediated Deacetylation","volume":"12","author":"Nalawansha","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"2026081707200160400_cit51","doi-asserted-by":"publisher","first-page":"6014","DOI":"10.3390\/cancers14236014","article-title":"Dual LSD1 and HDAC6\nInhibition Induces Doxorubicin Sensitivity in Acute Myeloid Leukemia\nCells","volume":"14","author":"Bulut","year":"2022","journal-title":"Cancers"}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c08483","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/145\/40\/22232\/3972867\/ja3c08483.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/145\/40\/22232\/3972867\/ja3c08483.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:32:22Z","timestamp":1786966342000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/145\/40\/22232\/400870\/Antibody-Free-Fluorine-Assisted-Metabolic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":51,"journal-issue":{"issue":"40","published-online":{"date-parts":[[2023,9,29]]},"published-print":{"date-parts":[[2023,10,11]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.3c08483","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,29]]}}}