{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:04:59Z","timestamp":1791547499074,"version":"4.3.4"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"publisher","award":["NRF-CRP26-2021-0002"],"award-info":[{"award-number":["NRF-CRP26-2021-0002"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52022094"],"award-info":[{"award-number":["52022094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2024,2,14]]},"DOI":"10.1021\/jacs.3c08622","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T15:12:26Z","timestamp":1706886746000},"page":"3675-3688","source":"Crossref","is-referenced-by-count":144,"title":["Single-Site Nanozymes with a Highly Conjugated Coordination Structure for Antitumor Immunotherapy via Cuproptosis and Cascade-Enhanced T Lymphocyte Activity"],"prefix":"10.1021","volume":"146","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Niu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7305-5852","authenticated-orcid":true,"given":"Yinghui","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7758-752X","authenticated-orcid":true,"given":"Shuyan","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-8611","authenticated-orcid":true,"given":"Hongjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People\u2019s Republic of China"},{"name":"Department of Chemistry, Tsinghua University, Beijing 100084, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-8360","authenticated-orcid":true,"given":"Yanli","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c09482"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00962-9"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2892"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201909729"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c13689"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b09112"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202301866"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202005111"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b05265"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802228"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202201542"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202005747"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00896E"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17670-y"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3726"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18794-x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00436-z"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113331"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801578"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202217339"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3833"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201906745"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11235-4"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b00999"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.02.025"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103088"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.04.002"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b02720"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwab139"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/accountsmr.2c00042"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau6584"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11719-3"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1703481"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30457-1"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201912642"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26724-8"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c07872"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208512"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202002274"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202205013"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202212267"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c00434"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202213922"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.9466"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-2199"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100262"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14909"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16199-4"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22693"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202305440"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307752"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-1012"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c08622","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c08622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T09:29:21Z","timestamp":1707902961000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.3c08622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,2,14]]}},"alternative-id":["10.1021\/jacs.3c08622"],"URL":"https:\/\/doi.org\/10.1021\/jacs.3c08622","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]}}}