{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:22:29Z","timestamp":1789388549864,"version":"build-2803163510"},"reference-count":87,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000165","name":"Division of Chemistry","doi-asserted-by":"publisher","award":["0848196"],"award-info":[{"award-number":["0848196"]}],"id":[{"id":"10.13039\/100000165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000152","name":"Division of Molecular and Cellular Biosciences","doi-asserted-by":"publisher","award":["MCB-1908587"],"award-info":[{"award-number":["MCB-1908587"]}],"id":[{"id":"10.13039\/100000152","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2024,2,14]]},"DOI":"10.1021\/jacs.3c11674","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T04:51:15Z","timestamp":1706676675000},"page":"3926-3942","source":"Crossref","is-referenced-by-count":9,"title":["The Active-Site [4Fe-4S] Cluster in the Isoprenoid Biosynthesis Enzyme IspH Adopts Unexpected Redox States during Ligand Binding and Catalysis"],"prefix":"10.1021","volume":"146","author":[{"given":"Selamawit","family":"Ghebreamlak","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, Auburn University, 179 Chemistry Building, Auburn, Alabama 36849, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3362-7697","authenticated-orcid":true,"given":"Sebastian A.","family":"Stoian","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Idaho, 875 Perimeter Drive, MS 2343 Moscow, Idaho 83844, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Lees","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Cronin","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Auburn University, 179 Chemistry Building, Auburn, Alabama 36849, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forrest","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery & Development, Auburn University, 4306 Walker Building, Auburn, Alabama 36849, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew O.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3307-2556","authenticated-orcid":true,"given":"Joshua","family":"Telser","sequence":"additional","affiliation":[{"name":"Department of Biological, Chemical and Physical Sciences, Roosevelt University, 430 S. Michigan Avenue, Chicago, Illinois 60605, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3100-0746","authenticated-orcid":true,"given":"Brian M.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4129-758X","authenticated-orcid":true,"given":"Evert C.","family":"Duin","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Auburn University, 179 Chemistry Building, Auburn, Alabama 36849, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/cr950040z"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/cr4004709"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-002-0359-x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/bi9729763"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/ja200763a"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.12.026"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03726-2"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1039\/a709175c"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5433.1573"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11860-5"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.2.735-738.2003"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1086\/424603"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330785"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2008.07.004"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/ar100026v"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/bi3001215"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911087107"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1039\/C3SC53301H"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.11.033"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.49.070180.001035"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/cr400479b"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1042\/bst0130572"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(75)90093-8"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(91)90066-9"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/ja029338e"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1023\/B:PRES.0000017195.05870.61"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1351\/pac199870040939"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ja051909q"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201104124"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ja303445z"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00537"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201502494"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201904676"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000264107"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ja048714n"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.2c01353"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/ct5005214"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5b00751"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/ja909664j"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201302343"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.crci.2007.01.016"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/ja00189a015"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.2001.2439"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1007\/s007750050345"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/ja980442z"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(02)02195-0"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.15227\/orgsyn.066.0211"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201000833"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(88)58067-9"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4173(82)90003-9"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1201\/9781420059588"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1006\/jmra.1996.0049"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/ja806693s"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1006\/jmra.1994.1180"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/0375-9601(74)90078-4"},{"key":"ref57\/cit57","first-page":"99","volume-title":"Applications of Physical Methods to Inorganic and Bioinorganic Chemistry","author":"Telser J.","year":"2007"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/ar0202565"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2010.10.008"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/ja903778d"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(84)90287-7"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/ja9700919"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/ja9012408"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201104562"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb12430.x"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)69741-3"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.12.005"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5326.653"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)39160-3"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1021\/bi060031s"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00766-8"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/bi9927890"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)48120-3"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/0162-0134(93)80043-9"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1980.tb04427.x"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/ja00131a021"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1007\/s007750050041"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)44398-5"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)85920-3"},{"key":"ref80\/cit80","first-page":"163","volume":"6","author":"Huynh B.-H.","year":"1984","journal-title":"Adv. Inorg. Chem."},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1007\/BF02354752"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1007\/s007750050008"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1021\/ja952845u"},{"key":"ref84\/cit84","volume-title":"Electron Paramagnetic Resonance","author":"Weil J. A.","year":"1994"},{"key":"ref85\/cit85","volume-title":"Introduction to Magnetic Resonance with Applications to Chemistry and Chemical Physics","author":"Carrington A.","year":"1967"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c07155"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c03062"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c11674","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c11674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T10:23:19Z","timestamp":1707906199000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.3c11674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,30]]},"references-count":87,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,2,14]]}},"alternative-id":["10.1021\/jacs.3c11674"],"URL":"https:\/\/doi.org\/10.1021\/jacs.3c11674","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,30]]}}}