{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:18:30Z","timestamp":1789654710606,"version":"4.0.1"},"reference-count":127,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2024,5,1]]},"DOI":"10.1021\/jacs.3c14574","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T21:53:55Z","timestamp":1713477235000},"page":"11726-11739","source":"Crossref","is-referenced-by-count":38,"title":["An Active Site Tyr Residue Guides the Regioselectivity of Lysine Hydroxylation by Nonheme Iron Lysine-4-hydroxylase Enzymes through Proton-Coupled Electron Transfer"],"prefix":"10.1021","volume":"146","author":[{"given":"Yuanxin","family":"Cao","sequence":"first","affiliation":[{"name":"Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom"},{"name":"Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3274-0938","authenticated-orcid":true,"given":"Sam","family":"Hay","sequence":"additional","affiliation":[{"name":"Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom"},{"name":"Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-8788","authenticated-orcid":true,"given":"Sam P.","family":"de Visser","sequence":"additional","affiliation":[{"name":"Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom"},{"name":"Department of Chemical Engineering, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1177\/2472555218817057"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.03.091"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.7150\/thno.65277"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30309-9"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.838548"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201402498"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00693-17"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201600934"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/catal11091038"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02859-z"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(99)00036-6"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/cr9900275"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/cr020628n"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/cr040653o"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.71"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","DOI":"10.1039\/9781849732987","volume-title":"Iron-Containing Enzymes: Versatile Catalysts of Hydroxylation Reactions in Nature","author":"de Visser S. P.","year":"2011"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.08.002"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/ar400258p"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1978-z"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2016.02.017"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2018.04.002"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34795-9"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/b707179p"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-016-1431-2"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.201800033"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/bi030011f"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ja039113j"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ja048255q"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ja074557r"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB02054J"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/catal12040354"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c03841"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b10526"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c05070"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh131"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00203"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00674"},{"key":"ref40\/cit40","volume-title":"AMBER-2018","author":"Case D. A.","year":"2018"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00255"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c03758"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c02096"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c01375"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202104167"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-022-00642-2"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202203875"},{"key":"ref48\/cit48","volume-title":"Gaussian-09","author":"Frisch M. J.","year":"2013"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00538"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1063\/1.464913"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.37.785"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1063\/1.448799"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1063\/1.1674902"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1063\/1.444267"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1063\/1.3382344"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b07374"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.2c00345"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.checat.2023.100732"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.2c07200"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c00761"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200305306"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1007\/s00214-005-0047-3"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/ja067899q"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/jp710999v"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/ct200614g"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/ic3021172"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.415570"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201304633"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202811"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1021\/ja507934g"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.5b12311"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.7b03477"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b02839"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202100393"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c01803"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c00024"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202104106"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c04029"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.3c03215"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202300271"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1021\/ja061609o"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503841"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200802597"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00944-x"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1126\/science.2549632"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1021\/ja991997c"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1021\/jp053873u"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1021\/ja047432k"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1021\/ja304609n"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1021\/ja508403w"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202200257"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1021\/ja403965h"},{"key":"ref93\/ref93_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318916"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5481.938"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1021\/ja510615p"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b08950"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b03157"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c00890"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201300110"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1132"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1021\/ic200522r"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1039\/c2cp42423a"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1021\/ja307077f"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b03597"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805511"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201812724"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202009347"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b05411"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202103452"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c13832"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1021\/ja908340j"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200900211"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1021\/cb700012y"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202004019"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1365494"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.1c00141"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c02262"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.213914"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12009"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c05128"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.20190293"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202003024"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC06295B"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202004906"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202100791"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09263"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1039\/D3CP01899G"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c14574","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.3c14574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T08:12:34Z","timestamp":1714551154000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.3c14574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":127,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2024,5,1]]}},"alternative-id":["10.1021\/jacs.3c14574"],"URL":"https:\/\/doi.org\/10.1021\/jacs.3c14574","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]}}}