{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:59:01Z","timestamp":1787313541686,"version":"build-2736575974"},"reference-count":94,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["A20E5c0087"],"award-info":[{"award-number":["A20E5c0087"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["MOE-T2EP30120-0007"],"award-info":[{"award-number":["MOE-T2EP30120-0007"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"publisher","award":["NRF-CRP22-2019-0002"],"award-info":[{"award-number":["NRF-CRP22-2019-0002"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2024,5,1]]},"DOI":"10.1021\/jacs.4c00537","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T15:02:06Z","timestamp":1713452526000},"page":"11811-11822","source":"Crossref","is-referenced-by-count":10,"title":["A Strain-Promoted Divergent Chemical Steroidation Unveils Potent Anti-Inflammatory Pseudo-Steroidal Glycosides"],"prefix":"10.1021","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-0723","authenticated-orcid":true,"given":"Han","family":"Ding","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Drugs of Ministry of Education, Shandong Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003 China"},{"name":"School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8283-0232","authenticated-orcid":true,"given":"Xiao-Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7072-4106","authenticated-orcid":true,"given":"Aoxin","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian Ping","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4377-3989","authenticated-orcid":true,"given":"Chao","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs of Ministry of Education, Shandong Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003 China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-5429","authenticated-orcid":true,"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs of Ministry of Education, Shandong Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003 China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4736-3143","authenticated-orcid":true,"given":"Hongzhi","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs of Ministry of Education, Shandong Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003 China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-6664","authenticated-orcid":true,"given":"Xue-Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs of Ministry of Education, Shandong Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003 China"},{"name":"School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"ref1\/cit1b","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"ref2\/cit2a","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00011-10"},{"key":"ref2\/cit2b","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13081878"},{"key":"ref3\/cit3a","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030740"},{"key":"ref3\/cit3b","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-34028-8"},{"key":"ref3\/cit3c","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-023-10303-8"},{"key":"ref4\/cit4a","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31612-1"},{"key":"ref4\/cit4b","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00327"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0306"},{"key":"ref6\/cit6a","doi-asserted-by":"publisher","DOI":"10.3390\/biom10040572"},{"key":"ref6\/cit6b","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/928290"},{"key":"ref6\/cit6c","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050913-021703"},{"key":"ref7\/cit7a","first-page":"203","volume":"14","author":"Ericson-Neilsen W.","year":"2014","journal-title":"Ochsner J."},{"key":"ref7\/cit7b","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/985495"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.2174\/187220809788700157"},{"key":"ref9\/cit9a","doi-asserted-by":"publisher","DOI":"10.1139\/v81-151"},{"key":"ref9\/cit9b","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.04.096"},{"key":"ref9\/cit9c","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.11.208"},{"key":"ref9\/cit9d","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2022.109062"},{"key":"ref9\/cit9e","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23406"},{"key":"ref9\/cit9f","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111637"},{"key":"ref9\/cit9g","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106700"},{"key":"ref9\/cit9h","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2023.109184"},{"key":"ref9\/cit9i","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041198"},{"key":"ref10\/cit10a","doi-asserted-by":"publisher","DOI":"10.1039\/p19810001855"},{"key":"ref10\/cit10b","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)90377-6"},{"key":"ref10\/cit10c","doi-asserted-by":"publisher","DOI":"10.1007\/BF01944532"},{"key":"ref10\/cit10d","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00332"},{"key":"ref10\/cit10e","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1601100914"},{"key":"ref10\/cit10f","doi-asserted-by":"publisher","DOI":"10.3390\/md15070227"},{"key":"ref11\/cit11a","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)73324-7"},{"key":"ref11\/cit11b","doi-asserted-by":"publisher","DOI":"10.1039\/D3OB00839H"},{"key":"ref12\/cit12a","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06915.x"},{"key":"ref12\/cit12b","doi-asserted-by":"publisher","DOI":"10.1080\/00397910802431198"},{"key":"ref12\/cit12c","doi-asserted-by":"publisher","DOI":"10.1007\/s00396-015-3750-1"},{"key":"ref13\/cit13a","doi-asserted-by":"publisher","DOI":"10.1038\/s41429-019-0172-1"},{"key":"ref13\/cit13b","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.3c00517"},{"key":"ref14\/cit14a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202203239"},{"key":"ref14\/cit14b","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202200784"},{"key":"ref14\/cit14c","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202200786"},{"key":"ref14\/cit14d","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202200787"},{"key":"ref15\/cit15a","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2010.03.018"},{"key":"ref15\/cit15b","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2013.07.106"},{"key":"ref15\/cit15c","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2014.01.007"},{"key":"ref15\/cit15d","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.11.16"},{"key":"ref16\/cit16a","doi-asserted-by":"publisher","DOI":"10.1039\/jr9520003361"},{"key":"ref16\/cit16b","doi-asserted-by":"publisher","DOI":"10.1021\/ja01598a041"},{"key":"ref16\/cit16c","doi-asserted-by":"publisher","DOI":"10.1021\/ja01525a074"},{"key":"ref16\/cit16d","doi-asserted-by":"publisher","DOI":"10.1021\/ol802343z"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b02963"},{"key":"ref18\/cit18a","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2008.04.017"},{"key":"ref18\/cit18b","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00573"},{"key":"ref18\/cit18c","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00209F"},{"key":"ref19\/cit19a","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.023.202202671"},{"key":"ref19\/cit19b","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39619-7"},{"key":"ref19\/cit19c","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC06619C"},{"key":"ref20\/cit20a","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.09.020"},{"key":"ref20\/cit20b","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-005-0141-2"},{"key":"ref20\/cit20c","doi-asserted-by":"publisher","DOI":"10.1080\/10915810590952951"},{"key":"ref20\/cit20d","doi-asserted-by":"publisher","DOI":"10.13189\/ujfns.2014.020201"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ac00240a040"},{"key":"ref22\/cit22a","first-page":"1265","volume":"97","author":"Yadav N.","year":"2020","journal-title":"J. Indian Chem. Soc."},{"key":"ref22\/cit22b","doi-asserted-by":"publisher","DOI":"10.1016\/j.bfopcu.2017.05.001"},{"key":"ref22\/cit22c","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23113002"},{"key":"ref23\/cit23a","doi-asserted-by":"publisher","DOI":"10.1039\/j39690002305"},{"key":"ref23\/cit23b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201914557"},{"key":"ref24\/cit24a","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00449"},{"key":"ref24\/cit24b","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6051"},{"key":"ref24\/cit24c","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201408739"},{"key":"ref25\/cit25a","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00533"},{"key":"ref25\/cit25b","doi-asserted-by":"publisher","DOI":"10.1063\/1.463096"},{"key":"ref25\/cit25c","doi-asserted-by":"publisher","DOI":"10.1063\/1.464913"},{"key":"ref25\/cit25d","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.37.785"},{"key":"ref25\/cit25e","doi-asserted-by":"publisher","DOI":"10.1021\/jp810292n"},{"key":"ref26\/cit26a","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.22885"},{"key":"ref26\/cit26b","doi-asserted-by":"publisher","DOI":"10.1002\/9783527829941.ch31"},{"key":"ref27\/cit27","unstructured":"Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V.; Petersson, G. A.; Nakatsuji, H.; Li, X.; Caricato, M.; Marenich, A. V.; Bloino, J.; Janesko, B. G.; Gomperts, R.; Mennucci, B.; Hratchian, H. P.; Ortiz, J. V.; Izmaylov, A. F.; Sonnenberg, J. L.; Williams-Young, D.; Ding, F.; Lipparini, F.; Egidi, F.; Goings, J.; Peng, B.; Petrone, A.; Henderson, T.; Ranasinghe, D.; Zakrzewski, V. G.; Gao, J.; Rega, N.; Zheng, G.; Liang, W.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Vreven, T.; Throssell, K.; Montgomery, J. A., Jr.; Peralta, J. E.; Ogliaro, F.; Bearpark, M. J.; Heyd, J. J.; Brothers, E. N.; Kudin, K. N.; Staroverov, V. N.; Keith, T. A.; Kobayashi, R.; Normand, J.; Raghavachari, K.; Rendell, A. P.; Burant, J. C.; Iyengar, S. S.; Tomasi, J.; Cossi, M.; Millam, J. M.; Klene, M.; Adamo, C.; Cammi, R.; Ochterski, J. W.; Martin, R. L.; Morokuma, K.; Farkas, O.; Foresman, J. B.; Fox, D. J.\n                      Gaussian 16, Revision C.01\n                      ; Gaussian, Inc.: Wallingford, CT, 2016."},{"key":"ref28\/cit28a","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2016.09.002"},{"key":"ref28\/cit28b","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.201700220"},{"key":"ref28\/cit28c","doi-asserted-by":"publisher","DOI":"10.1021\/ar5004658"},{"key":"ref28\/cit28d","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01107J"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00094"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2835"},{"key":"ref31\/cit31a","doi-asserted-by":"publisher","DOI":"10.2174\/092986712803341502"},{"key":"ref31\/cit31b","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-012-0190-1"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0690(20021)2002:1<171::AID-EJOC171>3.0.CO;2-7"},{"key":"ref33\/cit33a","doi-asserted-by":"publisher","DOI":"10.1021\/ol005732a"},{"key":"ref33\/cit33b","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b00485"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jm701272q"},{"key":"ref35\/cit35a","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-13-38"},{"key":"ref35\/cit35b","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201901071"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/biom11050659"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.24.701"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c00537","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c00537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T08:19:39Z","timestamp":1714551579000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.4c00537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":94,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2024,5,1]]}},"alternative-id":["10.1021\/jacs.4c00537"],"URL":"https:\/\/doi.org\/10.1021\/jacs.4c00537","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]}}}