{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:13:18Z","timestamp":1787062398177,"version":"build-2736575974"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001537","name":"University of Auckland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018883","name":"Maurice Wilkins Centre for Molecular Biodiscovery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2024,8,28]]},"DOI":"10.1021\/jacs.4c04567","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T03:51:55Z","timestamp":1723693915000},"page":"23717-23728","source":"Crossref","is-referenced-by-count":8,"title":["Use of a Cyclic \u03b1-Alkylidene-\u03b2-Diketone as a Cleavable Linker Strategy for Antibody-Drug Conjugates"],"prefix":"10.1021","volume":"146","author":[{"given":"Juliana T. W.","family":"Tong","sequence":"first","affiliation":[{"name":"School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makhdoom","family":"Sarwar","sequence":"additional","affiliation":[{"name":"Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand"},{"name":"Department of Obstetrics and Gynaecology, University of Otago, Christchurch, Christchurch 8011, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-7106","authenticated-orcid":true,"given":"Marzieh","family":"Ahangarpour","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Hume","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Otago, Christchurch, Christchurch 8011, New Zealand"},{"name":"School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington 6012, New Zealand"},{"name":"MacDiarmid Institute for Advanced Materials and Nanotechnology, Wellington 6012, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey M.","family":"Williams","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7086-4096","authenticated-orcid":true,"given":"Margaret A.","family":"Brimble","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2446-1376","authenticated-orcid":true,"given":"Iman","family":"Kavianinia","sequence":"additional","affiliation":[{"name":"Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand"},{"name":"School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00676H"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.07.048"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/cr980040+"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202402267"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01530"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26195847"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00947-7"},{"key":"ref8\/cit8","first-page":"71","volume-title":"Methods in Molecular Biology","volume":"1045","author":"Nolting B.","year":"2013"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00310G"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.268"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201904193"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.27436"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201307628"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/bc7004329"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC00957E"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020396"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC06410A"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309169"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201900531"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC01831A"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/bc100480a"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA04155F"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201604733"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)00101-0"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00555-3"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/c39930000778"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(96)00258-2"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b00177"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.38.3098"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1063\/1.462066"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1063\/1.3382344"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21759"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.10.013"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4058com"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM00613C"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2939"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.02.030"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c00992"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.01.035"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c04567","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c04567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T05:57:30Z","timestamp":1724824650000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.4c04567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,15]]},"references-count":39,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2024,8,28]]}},"alternative-id":["10.1021\/jacs.4c04567"],"URL":"https:\/\/doi.org\/10.1021\/jacs.4c04567","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,15]]}}}