{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:19:24Z","timestamp":1789773564343,"version":"4.0.1"},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1A2C1009706"],"award-info":[{"award-number":["2022R1A2C1009706"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01-GM141553"],"award-info":[{"award-number":["R01-GM141553"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005665","name":"Kinship Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2024,8,21]]},"DOI":"10.1021\/jacs.4c05623","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T18:02:51Z","timestamp":1723140171000},"page":"23230-23239","source":"Crossref","is-referenced-by-count":12,"title":["Discovery of Selective Inhibitors for the Lysosomal Parkinson\u2019s Disease Channel TMEM175"],"prefix":"10.1021","volume":"146","author":[{"given":"SeCheol","family":"Oh","sequence":"first","affiliation":[{"name":"Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chungbuk National University, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Jeong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chungbuk National University, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Sapuru","sequence":"additional","affiliation":[{"name":"Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States"},{"name":"Physiology, Biophysics, and Systems Biology (PBSB) Program, Weill Cornell Graduate School of Biomedical Sciences, 1300 York Avenue, New York, New York 10065, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-2682","authenticated-orcid":true,"given":"Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chungbuk National University, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-0669","authenticated-orcid":true,"given":"Richard K.","family":"Hite","sequence":"additional","affiliation":[{"name":"Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.002"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm1568"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.05.021"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03185-z"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1616332114"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.06.004"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2208882119"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53430"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.10"},{"issue":"6","key":"ref10\/cit10","first-page":"1227","volume":"45","author":"Grissmer S.","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ci200227u"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75122"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz136"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.06.017"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2009.00878.x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdev.2021.203713"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2018.0157"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32515-6"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(01)75749-9"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz4957"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80718-0"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56245-w"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c05623","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c05623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T03:25:07Z","timestamp":1724297107000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.4c05623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":22,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2024,8,21]]}},"alternative-id":["10.1021\/jacs.4c05623"],"URL":"https:\/\/doi.org\/10.1021\/jacs.4c05623","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]}}}