{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:29:25Z","timestamp":1792542565956,"version":"4.5.0"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100001260","name":"National Organization for Rare Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI142720"],"award-info":[{"award-number":["U19AI142720"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1R35GM150565"],"award-info":[{"award-number":["1R35GM150565"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2025,1,8]]},"DOI":"10.1021\/jacs.4c09582","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T09:03:13Z","timestamp":1735376593000},"page":"265-277","source":"Crossref","is-referenced-by-count":16,"title":["Discovery of a Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads"],"prefix":"10.1021","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-1789","authenticated-orcid":true,"given":"Dan","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Columbia, United States"]},{"name":"University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Columbia, United States"]},{"name":"University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Madden","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Columbia, United States"]},{"name":"University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Columbia, United States"]},{"name":"University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan A.","family":"Older","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Columbia, United States"]},{"name":"University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Pulliam","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Columbia, United States"]},{"name":"University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8012-1838","authenticated-orcid":true,"given":"Yvonne","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology","place":["Columbia, United States"]},{"name":"School of Medicine, University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Columbia, United States"]},{"name":"University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gourab","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences","place":["Columbia, United States"]},{"name":"University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikanda K.","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences","place":["Columbia, United States"]},{"name":"University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy","place":["Columbia, United States"]},{"name":"School of Medicine, University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Sardi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology","place":["Baltimore, United States"]},{"name":"The Institute for Cancer Care at Mercy, Mercy Medical Center","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoling","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Biological and Physical Sciences","place":["Orangeburg, United States"]},{"name":"South Carolina State University","place":["Orangeburg, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hexin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences","place":["Columbia, United States"]},{"name":"University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daping","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy","place":["Columbia, United States"]},{"name":"School of Medicine, University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim S.","family":"Bugni","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Division","place":["Madison, United States"]},{"name":"University of Wisconsin\u2212Madison","place":["Madison, United States"]},{"name":"Lachman Institute for Pharmaceutical Development, University of Wisconsin\u2212Madison","place":["Madison, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3883-6407","authenticated-orcid":true,"given":"Traci L.","family":"Testerman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology","place":["Columbia, United States"]},{"name":"School of Medicine, University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9677-9017","authenticated-orcid":true,"given":"Qihao","family":"Wu","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Division","place":["Madison, United States"]},{"name":"University of Wisconsin\u2212Madison","place":["Madison, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-6749","authenticated-orcid":true,"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Columbia, United States"]},{"name":"University of South Carolina","place":["Columbia, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.824321"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(01)00138-2"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02361-4"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109821"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nm1523"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.01.050"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nri2216"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1308681"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1039\/B515619J"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1039\/D2NP00080F"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1039\/C3NP70078J"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1039\/C8NP00057C"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/biology10090849"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.3.6.755"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.2174\/092986706777585004"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(76)80019-9"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa172"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-023-03058-7"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3597"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn603"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0344-8"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507743112"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1039\/C9NP00004F"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00413"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.8b00760"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813215"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202114022"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00834-2"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3198"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12020258"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1515\/pp-2016-0008"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00737"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.1c00179"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3390\/molecules181214629"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/nature08296"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/md20020082"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c00301"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c01365"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1107\/S0108270111005816"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c06410"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202103878"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad344"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072871"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c02719"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB00198K"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201915514"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3390\/jof8030320"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1039\/D0NP00080A"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c06538"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/jo00370a019"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-021-03072-6"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.183"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810222"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14356"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22169030"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.01.010"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b09739"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c10369"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32901-0"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2117941119"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b07588"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.0c00139"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.8b00389"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c09582","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c09582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T10:07:49Z","timestamp":1740478069000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.4c09582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,8]]}},"alternative-id":["10.1021\/jacs.4c09582"],"URL":"https:\/\/doi.org\/10.1021\/jacs.4c09582","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.11.05.622009","asserted-by":"object"}]},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,28]]}}}