{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:39:28Z","timestamp":1792147168821,"version":"4.4.0"},"reference-count":132,"publisher":"American Chemical Society (ACS)","issue":"44","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100006734","name":"Princeton University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["101022733"],"award-info":[{"award-number":["101022733"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5R01GM121441"],"award-info":[{"award-number":["5R01GM121441"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2024,11,6]]},"DOI":"10.1021\/jacs.4c12329","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T11:16:16Z","timestamp":1729854976000},"page":"30637-30652","source":"Crossref","is-referenced-by-count":11,"title":["Redox-Neutral, Iron-Mediated Directed C\u2013H Activation: General Principles and Mechanistic Insights"],"prefix":"10.1021","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-3102","authenticated-orcid":true,"given":"Tianyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry","place":["Princeton, United States"]},{"name":"Princeton University","place":["Princeton, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9789-1265","authenticated-orcid":true,"given":"William G.","family":"Whitehurst","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Princeton, United States"]},{"name":"Princeton University","place":["Princeton, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2583-5314","authenticated-orcid":true,"given":"Matthew V.","family":"Pecoraro","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Princeton, United States"]},{"name":"Princeton University","place":["Princeton, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8977-2925","authenticated-orcid":true,"given":"Junho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Princeton, United States"]},{"name":"Princeton University","place":["Princeton, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1878-614X","authenticated-orcid":true,"given":"Stefan G.","family":"Koenig","sequence":"additional","affiliation":[{"name":"Synthetic Molecule Process Chemistry","place":["South San Francisco, United States"]},{"name":"Genentech Inc","place":["South San Francisco, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-2898","authenticated-orcid":true,"given":"Paul J.","family":"Chirik","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Princeton, United States"]},{"name":"Princeton University","place":["Princeton, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/ar00051a009"},{"key":"ref2\/cit2a","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00162E"},{"key":"ref2\/cit2b","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00086K"},{"key":"ref2\/cit2c","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA14399G"},{"key":"ref2\/cit2d","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00034"},{"key":"ref2\/cit2e","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.2c00508"},{"key":"ref2\/cit2f","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114731"},{"key":"ref3\/cit3a","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183281"},{"key":"ref3\/cit3b","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114731"},{"key":"ref3\/cit3c","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/3-540-68525-1_2","volume-title":"Activation of Unreactive Bonds and Organic Synthesis","author":"Jones W. D.","year":"1999"},{"key":"ref3\/cit3d","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200806273"},{"key":"ref3\/cit3e","doi-asserted-by":"publisher","DOI":"10.1021\/ar300014f"},{"key":"ref3\/cit3f","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-15334-1_6"},{"key":"ref3\/cit3g","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201310544"},{"key":"ref3\/cit3h","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00444"},{"key":"ref3\/cit3i","doi-asserted-by":"publisher","DOI":"10.1007\/3418_2015_140"},{"key":"ref3\/cit3j","doi-asserted-by":"publisher","DOI":"10.1021\/ar200190g"},{"key":"ref3\/cit3k","doi-asserted-by":"publisher","DOI":"10.1021\/op200046v"},{"key":"ref3\/cit3l","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b01645"},{"key":"ref3\/cit3m","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201400110"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","unstructured":"Barbu, B. Elements of a Green Catalyst. Chemical & Engineering News. https:\/\/cen.acs.org\/synthesis\/catalysis\/elements-green-catalyst\/102\/i5 (accessed April 14, 2024).","DOI":"10.1021\/cen-10205-cover"},{"key":"ref5\/cit5a","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00507"},{"key":"ref5\/cit5b","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c00933"},{"key":"ref5\/cit5c","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00574"},{"key":"ref5\/cit5d","doi-asserted-by":"publisher","DOI":"10.1021\/cr0104330"},{"key":"ref5\/cit5e","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00634"},{"key":"ref5\/cit5f","first-page":"1","volume-title":"Handbook of CH-Functionalization","author":"Kamitani M.","year":"2022"},{"key":"ref6\/cit6a","volume-title":"Topics in Organometallic Chemistry","volume":"56","author":"Dixneuf P. H.","year":"2016"},{"key":"ref6\/cit6b","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00294"},{"key":"ref6\/cit6c","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00772"},{"key":"ref6\/cit6d","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.6b00272"},{"key":"ref6\/cit6e","doi-asserted-by":"publisher","DOI":"10.1021\/jo100693m"},{"key":"ref7\/cit7","volume-title":"Periodic Table of the Elements","author":"Halka M.","year":"2011"},{"key":"ref8\/cit8a","doi-asserted-by":"publisher","DOI":"10.1080\/026520399283876"},{"key":"ref8\/cit8b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201603777"},{"key":"ref9\/cit9a","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2007.02.037"},{"key":"ref9\/cit9b","doi-asserted-by":"publisher","DOI":"10.1021\/cr400415k"},{"key":"ref9\/cit9c","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2018.10.004"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/ja01011a012"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ja00435a068"},{"key":"ref12\/cit12a","doi-asserted-by":"publisher","DOI":"10.1021\/ja00072a016"},{"key":"ref12\/cit12b","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c04837"},{"key":"ref12\/cit12c","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c00772"},{"key":"ref12\/cit12d","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-023-01105-0"},{"key":"ref13\/cit13a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200460978"},{"key":"ref13\/cit13b","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2014.12.006"},{"key":"ref13\/cit13c","doi-asserted-by":"publisher","DOI":"10.1021\/om800828j"},{"key":"ref13\/cit13d","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b08385"},{"key":"ref13\/cit13e","doi-asserted-by":"publisher","DOI":"10.1021\/om2005589"},{"key":"ref14\/cit14a","doi-asserted-by":"publisher","DOI":"10.1021\/ja00250a060"},{"key":"ref14\/cit14b","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC04394G"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-328X(00)93742-2"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/ja00150a041"},{"key":"ref17\/cit17a","doi-asserted-by":"publisher","DOI":"10.1021\/om301219t"},{"key":"ref17\/cit17b","doi-asserted-by":"publisher","DOI":"10.1021\/acs.organomet.6b00276"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/ja8063028"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200603224"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200204570"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ja028394c"},{"key":"ref22\/cit22a","doi-asserted-by":"publisher","DOI":"10.1039\/B413409E"},{"key":"ref22\/cit22b","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200800397"},{"key":"ref22\/cit22c","doi-asserted-by":"publisher","DOI":"10.1021\/om800828j"},{"key":"ref22\/cit22d","doi-asserted-by":"publisher","DOI":"10.1039\/C4DT00944D"},{"key":"ref22\/cit22e","doi-asserted-by":"publisher","DOI":"10.1021\/om9007218"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200460978"},{"key":"ref24\/cit24a","doi-asserted-by":"publisher","DOI":"10.1021\/om4010274"},{"key":"ref24\/cit24b","doi-asserted-by":"publisher","DOI":"10.1021\/om500794f"},{"key":"ref24\/cit24c","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201900501"},{"key":"ref24\/cit24d","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07689"},{"key":"ref25\/cit25a","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC05607G"},{"key":"ref25\/cit25b","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC01661J"},{"key":"ref25\/cit25c","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b05269"},{"key":"ref25\/cit25d","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201904018"},{"key":"ref25\/cit25e","doi-asserted-by":"publisher","DOI":"10.1021\/acs.organomet.1c00100"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b02387"},{"key":"ref27\/cit27a","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12646"},{"key":"ref27\/cit27b","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c01874"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08865"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/om800091a"},{"key":"ref33\/cit33a","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23217"},{"key":"ref33\/cit33b","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123176"},{"key":"ref33\/cit33c","doi-asserted-by":"publisher","DOI":"10.1021\/ja00713a007"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ic00289a026"},{"key":"ref36\/cit36a","first-page":"1267","volume":"6","author":"Lobkovskii E. B.","year":"1980","journal-title":"Koord. Khim."},{"key":"ref36\/cit36b","doi-asserted-by":"publisher","DOI":"10.1039\/dt9950000301"},{"key":"ref36\/cit36c","doi-asserted-by":"publisher","DOI":"10.1039\/C9DT04821A"},{"key":"ref36\/cit36d","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-023-01105-0"},{"key":"ref37\/cit37a","doi-asserted-by":"publisher","DOI":"10.1021\/om00147a014"},{"key":"ref37\/cit37b","doi-asserted-by":"publisher","DOI":"10.1021\/ic048202+"},{"key":"ref38\/cit38a","doi-asserted-by":"publisher","DOI":"10.1021\/ja011105k"},{"key":"ref38\/cit38b","unstructured":"b References for (TMEDA)MgMe2:"},{"key":"ref38\/cit38c","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19881211108"},{"key":"ref38\/cit38d","doi-asserted-by":"publisher","DOI":"10.1021\/acs.organomet.0c00775"},{"key":"ref40\/cit40a","doi-asserted-by":"publisher","DOI":"10.1021\/jo00414a017"},{"key":"ref40\/cit40b","doi-asserted-by":"publisher","DOI":"10.1021\/ja01030a023"},{"key":"ref40\/cit40c","unstructured":"cEliel, E. L.; Wilen, S. H.; Doyle, M. P. Basic Organic Stereochemistry; Wiley-Interscience: New York, 2001; p 443."},{"key":"ref40\/cit40d","unstructured":"dEliel, E. L.; Wilen, S. H. Stereochemistry of Organic Compounds; John Wiley & Sons, 1994; p 696."},{"key":"ref40\/cit40e","first-page":"139","volume-title":"Advances in Alicyclic Chemistry","volume":"3","author":"Jensen F. R.","year":"1971"},{"key":"ref40\/cit40f","doi-asserted-by":"publisher","DOI":"10.1002\/9780470147108.ch4"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201500225"},{"key":"ref42\/cit42a","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b00364"},{"key":"ref42\/cit42b","doi-asserted-by":"publisher","DOI":"10.1021\/ja905816q"},{"key":"ref42\/cit42c","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c01059"},{"key":"ref42\/cit42d","unstructured":"d See also ref (25)."},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC04698K"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.91.146401"},{"key":"ref45\/cit45a","doi-asserted-by":"publisher","DOI":"10.1039\/b508541a"},{"key":"ref45\/cit45b","doi-asserted-by":"publisher","DOI":"10.1063\/1.467146"},{"key":"ref45\/cit45c","doi-asserted-by":"publisher","DOI":"10.1039\/b515623h"},{"key":"ref45\/cit45d","doi-asserted-by":"publisher","DOI":"10.1063\/1.463096"},{"key":"ref45\/cit45e","doi-asserted-by":"publisher","DOI":"10.1063\/1.3484283"},{"key":"ref45\/cit45f","doi-asserted-by":"publisher","DOI":"10.1039\/C4CP04286G"},{"key":"ref46\/cit46a","doi-asserted-by":"publisher","DOI":"10.1063\/1.1626543"},{"key":"ref46\/cit46b","doi-asserted-by":"publisher","DOI":"10.1021\/jp900654j"},{"key":"ref46\/cit46c","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.8b01821"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b12150"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC01661J"},{"key":"ref49\/cit49a","doi-asserted-by":"publisher","DOI":"10.1021\/ja051497l"},{"key":"ref49\/cit49b","doi-asserted-by":"publisher","DOI":"10.1021\/ja034126i"},{"key":"ref49\/cit49c","doi-asserted-by":"publisher","DOI":"10.1021\/ja038399p"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19520350721"},{"key":"ref51\/cit51a","doi-asserted-by":"publisher","DOI":"10.1021\/om00156a028"},{"key":"ref51\/cit51b","doi-asserted-by":"publisher","DOI":"10.1021\/ja00163a029"},{"key":"ref51\/cit51c","doi-asserted-by":"publisher","DOI":"10.1021\/ja00227a022"},{"key":"ref51\/cit51d","doi-asserted-by":"publisher","DOI":"10.1021\/om00037a029"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj4213"},{"key":"ref53\/cit53a","doi-asserted-by":"publisher","DOI":"10.1021\/ja00235a031"},{"key":"ref53\/cit53b","doi-asserted-by":"publisher","DOI":"10.1021\/om400760k"},{"key":"ref53\/cit53c","doi-asserted-by":"publisher","DOI":"10.1021\/ja00359a023"},{"key":"ref54\/cit54a","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.11.006"},{"key":"ref54\/cit54b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202111462"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/ja042672l"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c12329","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c12329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T10:31:05Z","timestamp":1740479465000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.4c12329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":132,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2024,11,6]]}},"alternative-id":["10.1021\/jacs.4c12329"],"URL":"https:\/\/doi.org\/10.1021\/jacs.4c12329","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,25]]}}}