{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:12:38Z","timestamp":1791454358391,"version":"4.3.3"},"reference-count":61,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100009076","name":"University of Science and Technology of China","doi-asserted-by":"publisher","award":["YD2060006006"],"award-info":[{"award-number":["YD2060006006"]}],"id":[{"id":"10.13039\/501100009076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0710700"],"award-info":[{"award-number":["2020YFA0710700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52021002"],"award-info":[{"award-number":["52021002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52233009"],"award-info":[{"award-number":["52233009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52273155"],"award-info":[{"award-number":["52273155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52350348"],"award-info":[{"award-number":["52350348"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52425306"],"award-info":[{"award-number":["52425306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92356302"],"award-info":[{"award-number":["92356302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB0450102"],"award-info":[{"award-number":["XDB0450102"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB0450301"],"award-info":[{"award-number":["XDB0450301"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["YSBR-094"],"award-info":[{"award-number":["YSBR-094"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2025,1,22]]},"DOI":"10.1021\/jacs.4c17178","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:41:39Z","timestamp":1736401299000},"page":"2889-2901","source":"Crossref","is-referenced-by-count":19,"title":["Optimizing Surface Maleimide\/cRGD Ratios Enhances Targeting Efficiency of cRGD-Functionalized Nanomedicines"],"prefix":"10.1021","volume":"147","author":[{"given":"Rundi","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuben","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxuan","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runjie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-1343","authenticated-orcid":true,"given":"Jinming","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9789-6282","authenticated-orcid":true,"given":"Shiyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1566"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2614"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b09974"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b04400"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.09.013"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.1c00546"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.10.003"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c09029"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(99)00062-9"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90233-9"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1159\/000055396"},{"issue":"18","key":"ref12\/cit12","first-page":"5139","volume":"62","author":"Zitzmann S.","year":"2002","journal-title":"Cancer Res."},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/mp060049x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.7150\/thno.13242"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01666"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100556"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.10.019"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0567-y"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c11666"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-008-2231-5"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/bc00031a015"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/bc900087a"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/bc500028d"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b00670"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c07577"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68359-6"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/bc5004313"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2010.02.007"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.03.002"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c04454"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/bc800547c"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.03.005"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200460800"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/bm8002013"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-021-00561-5"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00129H"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b03995"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12205"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0021-z"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00129H"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/ja107583h"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805740"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.237"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b10950"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34438-8"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.05.010"},{"key":"ref48\/cit48","unstructured":"Landrum, G. Rdkit: Open-source Cheminformatics Software, version 2016.03; Zenodo 2016."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096-987x(199604)17:5\/63.0.co;2-q"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2020.107532"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1007\/s13758-012-0048-4"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.1.127"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-012-0818-1"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020594"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.01.020"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s40005-019-00442-2"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.269"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c02821"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1398"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35579-6"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c17178","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.4c17178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T09:13:11Z","timestamp":1737537191000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.4c17178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,9]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,1,22]]}},"alternative-id":["10.1021\/jacs.4c17178"],"URL":"https:\/\/doi.org\/10.1021\/jacs.4c17178","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,9]]}}}