{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:24:29Z","timestamp":1788265469731,"version":"build-2803163510"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"15","license":[{"start":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T00:00:00Z","timestamp":1459036800000},"content-version":"vor","delay-in-days":366,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM-086483"],"award-info":[{"award-number":["GM-086483"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI-85077"],"award-info":[{"award-number":["AI-85077"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006488","name":"Division of Agriculture and Natural Resources, University of California","doi-asserted-by":"publisher","award":["CA-R-NEU-5048-H"],"award-info":[{"award-number":["CA-R-NEU-5048-H"]}],"id":[{"id":"10.13039\/100006488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial activity, in spite of the fact that kalihinol A is the most potent among the members of the larger family of antimalarial isocyanoterpenes. We have validated a strategy designed to access many of the kalihinanes with a 12-step enantioselective synthesis of kalihinol B, the tetrahydrofuran isomer of kalihinol A (a tetrahydropyran). Kalihinol B shows similarly high potency against chloroquine-resistant Plasmodium falciparum.<\/jats:p>","DOI":"10.1021\/jacs.5b01152","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T11:53:36Z","timestamp":1427457216000},"page":"4912-4915","source":"Crossref","is-referenced-by-count":46,"title":["Synthesis\nand Potent Antimalarial Activity of Kalihinol\nB"],"prefix":"10.1021","volume":"137","author":[{"given":"Mary Elisabeth","family":"Daub","sequence":"first","affiliation":[{"name":"University of California, Irvine , , 1102 Natural Sciences II, , ,","place":["Irvine, California, United States, 92697-2025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Prudhomme","sequence":"additional","affiliation":[{"name":"University of California, Riverside , , 900 University Avenue , , ,","place":["Riverside, California, United States, 92521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Le Roch","sequence":"additional","affiliation":[{"name":"University of California, Riverside , , 900 University Avenue , , ,","place":["Riverside, California, United States, 92521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Vanderwal","sequence":"additional","affiliation":[{"name":"University of California, Irvine , , 1102 Natural Sciences II, , ,","place":["Irvine, California, United States, 92697-2025"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"2026090108032764100_cit1a","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1021\/np50090a014","volume":"55","author":"Angerhofer","year":"1992","journal-title":"J. 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