{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:47:26Z","timestamp":1791323246910,"version":"4.3.1"},"reference-count":33,"publisher":"American Chemical Society (ACS)","issue":"44","funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM058133"],"award-info":[{"award-number":["GM058133"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2015,11,11]]},"DOI":"10.1021\/jacs.5b09869","type":"journal-article","created":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T16:20:38Z","timestamp":1446394838000},"page":"14047-14050","source":"Crossref","is-referenced-by-count":15,"title":["A \u201cMethyl Extension\u201d Strategy for Polyketide Natural Product Linker Site Validation and Its Application to Dictyostatin"],"prefix":"10.1021","volume":"137","author":[{"given":"Stephen","family":"Ho","sequence":"first","affiliation":[{"name":"Department\rof Chemistry, Columbia University, New York, New York 10027, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan L.","family":"Sackett","sequence":"additional","affiliation":[{"name":"Program\rin Physical Biology, Eunice Kennedy Shriver National Institute of\rChild Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Leighton","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, Columbia University, New York, New York 10027, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,11,3]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"publisher","DOI":"10.1039\/c3np20113a"},{"key":"ref1\/cit1b","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.11.004"},{"key":"ref1\/cit1c","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201307628"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/bc9002019"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1039\/c39940001111"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00192-8"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/b316390c"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201302565"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/ml400233e"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.02.031"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/ja961374o"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201000541"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ol0526827"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2007.05.033"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/jm061385k"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/ja103537u"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1351\/PAC-CON-08-09-17"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.10.084"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ja1023817"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200800039"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230582"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/ja200712f"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ja001179g"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020301)41:5<807::AID-ANIE807>3.0.CO;2-V"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200705621"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/jo030367x"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19980817)37:15<1986::AID-ANIE1986>3.0.CO;2-Z"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/ol500051e"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201003761"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ja044996f"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200705365"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ol0060174"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/ol006054v"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5b09869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T13:06:01Z","timestamp":1681650361000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5b09869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,3]]},"references-count":33,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2015,11,11]]}},"alternative-id":["10.1021\/jacs.5b09869"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5b09869","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,3]]}}}