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Highlights include an unprecedented late-stage large-fragment Petasis\u2013Ferrier union\/rearrangement, a multicomponent Type I Anion Relay Chemistry (ARC) tactic, and a dithiane\u2013epoxide union in conjunction with an oxazole-directed stereoselective reduction.<\/jats:p>","DOI":"10.1021\/jacs.5b11540","type":"journal-article","created":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T14:18:48Z","timestamp":1449152328000},"page":"15426-15429","source":"Crossref","is-referenced-by-count":41,"title":["Total Synthesis of (\u2212)-Enigmazole A"],"prefix":"10.1021","volume":"137","author":[{"given":"Yanran","family":"Ai","sequence":"first","affiliation":[{"name":"University of Pennsylvania , , , Pennsylvania ,","place":["Philadelphia, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya V.","family":"Kozytska","sequence":"additional","affiliation":[{"name":"University of Pennsylvania , , , Pennsylvania ,","place":["Philadelphia, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yike","family":"Zou","sequence":"additional","affiliation":[{"name":"University of Pennsylvania , , , Pennsylvania ,","place":["Philadelphia, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton S.","family":"Khartulyari","sequence":"additional","affiliation":[{"name":"University of Pennsylvania , , , Pennsylvania ,","place":["Philadelphia, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Amos B.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Pennsylvania , , , Pennsylvania ,","place":["Philadelphia, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,12,3]]},"reference":[{"key":"2026090120563784900_cit1","doi-asserted-by":"publisher","first-page":"10278","DOI":"10.1021\/ja1016766","volume":"132","author":"Oku","year":"2010","journal-title":"J. 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