{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:37:57Z","timestamp":1790818677034,"version":"4.1.0"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"9","funder":[{"DOI":"10.13039\/100000060","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["AI080968"],"award-info":[{"award-number":["AI080968"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["GM051501"],"award-info":[{"award-number":["GM051501"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["GM070855"],"award-info":[{"award-number":["GM070855"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DEG-12262"],"award-info":[{"award-number":["DEG-12262"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2016,3,9]]},"DOI":"10.1021\/jacs.5b13008","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T15:45:41Z","timestamp":1455551141000},"page":"3136-3144","source":"Crossref","is-referenced-by-count":64,"title":["Ribosome-Templated Azide\u2013Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry"],"prefix":"10.1021","volume":"138","author":[{"given":"Ian","family":"Glassford","sequence":"first","affiliation":[{"name":"Department\rof Chemistry, Temple University, Philadelphia, Pennsylvania 19122, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana N.","family":"Teijaro","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, Temple University, Philadelphia, Pennsylvania 19122, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer S.","family":"Daher","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, Temple University, Philadelphia, Pennsylvania 19122, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Weil","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan C.","family":"Small","sequence":"additional","affiliation":[{"name":"Department\rof Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv K.","family":"Redhu","sequence":"additional","affiliation":[{"name":"Department\rof Biology, Temple University, Philadelphia, Pennsylvania 19122, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"Colussi","sequence":"additional","affiliation":[{"name":"Moulder Center\rfor Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene A.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Moulder Center\rfor Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne E.","family":"Childers","sequence":"additional","affiliation":[{"name":"Moulder Center\rfor Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Buttaro","sequence":"additional","affiliation":[{"name":"Department\rof Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen W.","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Department\rof Biology, Temple University, Philadelphia, Pennsylvania 19122, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Alexander D.","family":"MacKerell","sequence":"additional","affiliation":[{"name":"Department\rof Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry S.","family":"Cooperman","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo B.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, Temple University, Philadelphia, Pennsylvania 19122, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro727"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1145"},{"key":"ref3\/cit3","first-page":"938","volume":"89","author":"Solomon S. L.","year":"2014","journal-title":"Am. Fam. Physician"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2693"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1206-1521"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201310843"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2011.036.10.1622079"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2000.00185.x"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05063.x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3367-3372.2005"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00217518"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00860-10"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.7.4046"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1039\/b901969n"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ja0749993"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1467"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/bi3005126"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/ja046382g"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020315)41:6<1053::AID-ANIE1053>3.0.CO;2-4"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/ja043031t"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/ja3001858"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200461580"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200502161"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2009.28"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/C1CC14724B"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ja030494a"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.1.6.525"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/cb100177g"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201406465"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/ja2064389"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200900488"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076224"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201305882"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/nn404296k"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2223"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.01.027"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.07.032"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/ci4005628"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/ci100462t"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000435"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/ci500729k"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/jm0100279"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2008.08.003"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007988107"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1039\/p29740001760"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks232"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1086\/647952"},{"key":"ref54\/cit54","unstructured":"GM05659, Fibroblast from Skin, Chest;Coriell Institute for Medical Research:Camden, NJ;https:\/\/catalog.coriell.org\/0\/Sections\/Search\/Sample_Detail.aspx?Ref=GM05659, accessed 2\/10\/16."},{"key":"ref55\/cit55","unstructured":"CellTiter-Glo Luminescent Cell Viability Assay;Promega:Madison, WI;https:\/\/www.promega.com\/products\/cell-health-and-metabolism\/cell-viability-assays\/celltiter_glo-luminescent-cell-viability-assay\/, accessed 2\/10\/16."}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5b13008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T12:53:03Z","timestamp":1682167983000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5b13008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,26]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,3,9]]}},"alternative-id":["10.1021\/jacs.5b13008"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5b13008","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,26]]}}}