{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:37:23Z","timestamp":1789504643237,"version":"build-2803163510"},"reference-count":31,"publisher":"American Chemical Society (ACS)","issue":"25","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2023YFA0915201"],"award-info":[{"award-number":["2023YFA0915201"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2024YFA1308500"],"award-info":[{"award-number":["2024YFA1308500"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z231100007223003"],"award-info":[{"award-number":["Z231100007223003"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z241100007724005"],"award-info":[{"award-number":["Z241100007724005"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["JQ24007"],"award-info":[{"award-number":["JQ24007"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477122"],"award-info":[{"award-number":["22477122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32188101"],"award-info":[{"award-number":["32188101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangzhou Laboratory","award":["GZNL2023A01008"],"award-info":[{"award-number":["GZNL2023A01008"]}]},{"name":"Guangzhou Laboratory","award":["SRPG22-003"],"award-info":[{"award-number":["SRPG22-003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2025,6,25]]},"DOI":"10.1021\/jacs.5c05014","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:20:31Z","timestamp":1749792031000},"page":"21896-21906","source":"Crossref","is-referenced-by-count":7,"title":["Structural Basis and Rational Design of Nucleotide Analogue Inhibitor Evading the SARS-CoV-2 Proofreading Enzyme"],"prefix":"10.1021","volume":"147","author":[{"given":"Junbo","family":"Wang","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Protein Science, School of Medicine","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Pan","sequence":"additional","affiliation":[{"name":"MOE Engineering Research Center of Advanced Rare Earth Materials, Department of Chemistry","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiao","family":"Liu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Protein Science, School of Medicine","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-9110","authenticated-orcid":true,"given":"Bo","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing StoneWise Technology Co Ltd.","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Jin","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Protein Science, School of Medicine","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lejin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing StoneWise Technology Co Ltd.","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State key laboratory of antiviral drugs","place":["Zhengzhou, China"]},{"name":"Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucen","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Yan","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Protein Science, School of Medicine","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0653-7760","authenticated-orcid":true,"given":"Yuanchen","family":"Dong","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics","place":["Beijing, China"]},{"name":"Institute of Chemistry, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihe","family":"Rao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Protein Science, School of Medicine","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]},{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]},{"name":"Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology","place":["Shanghai, China"]},{"name":"ShanghaiTech University","place":["Shanghai, China"]},{"name":"National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules","place":["Beijing, China"]},{"name":"Institute of Biophysics, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Guangzhou Laboratory","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2583-818X","authenticated-orcid":true,"given":"Dongsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"MOE Engineering Research Center of Advanced Rare Earth Materials, Department of Chemistry","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]},{"name":"Department of Applied Biology and Chemical Technology","place":["Hong Hum, Hong Kong"]},{"name":"The Hong Kong Polytechnic University","place":["Hong Hum, Hong Kong"]},{"name":"PolyU Shenzhen Research Institute","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Lou","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Protein Science, School of Medicine","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007314"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-26765-4_3"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-052521-115653"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00630-8"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.4161\/rna.8.2.15013"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2006.01.017"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2012.07.005"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.07.027"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2324-7"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718806115"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01813"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi9310"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.11.048"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.04.004"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00221-18"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003565"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508200103"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000896"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01296-07"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808790106"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508686112"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000863"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201130109"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73641-9"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101518"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-018-0099-4"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky970"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1034811"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c01679"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01348-19"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.244-254.2003"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c05014","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c05014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T08:14:29Z","timestamp":1750839269000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c05014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,13]]},"references-count":31,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2025,6,25]]}},"alternative-id":["10.1021\/jacs.5c05014"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5c05014","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,13]]}}}