{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:24:27Z","timestamp":1790148267270,"version":"4.0.1"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2025,8,13]]},"DOI":"10.1021\/jacs.5c06971","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T15:59:46Z","timestamp":1754063986000},"page":"28943-28954","source":"Crossref","is-referenced-by-count":9,"title":["The Structure of Human IAPP Fibrils Reflects Membrane and pH Conditions"],"prefix":"10.1021","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-9776","authenticated-orcid":true,"given":"Venus Singh","family":"Mithu","sequence":"first","affiliation":[{"name":"Department of NMR-based Structural Biology","place":["G\u00f6ttingen, Germany"]},{"name":"Max Planck Institute of Multidisciplinary Sciences","place":["G\u00f6ttingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Giller","sequence":"additional","affiliation":[{"name":"Department of NMR-based Structural Biology","place":["G\u00f6ttingen, Germany"]},{"name":"Max Planck Institute of Multidisciplinary Sciences","place":["G\u00f6ttingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Nimerovsky","sequence":"additional","affiliation":[{"name":"Department of NMR-based Structural Biology","place":["G\u00f6ttingen, Germany"]},{"name":"Max Planck Institute of Multidisciplinary Sciences","place":["G\u00f6ttingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Overkamp","sequence":"additional","affiliation":[{"name":"Department of NMR-based Structural Biology","place":["G\u00f6ttingen, Germany"]},{"name":"Max Planck Institute of Multidisciplinary Sciences","place":["G\u00f6ttingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-9065","authenticated-orcid":true,"given":"Loren B.","family":"Andreas","sequence":"additional","affiliation":[{"name":"Department of NMR-based Structural Biology","place":["G\u00f6ttingen, Germany"]},{"name":"Max Planck Institute of Multidisciplinary Sciences","place":["G\u00f6ttingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of NMR-based Structural Biology","place":["G\u00f6ttingen, Germany"]},{"name":"Max Planck Institute of Multidisciplinary Sciences","place":["G\u00f6ttingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-4344","authenticated-orcid":true,"given":"Christian","family":"Griesinger","sequence":"additional","affiliation":[{"name":"Department of NMR-based Structural Biology","place":["G\u00f6ttingen, Germany"]},{"name":"Max Planck Institute of Multidisciplinary Sciences","place":["G\u00f6ttingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11080515"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00703.2009"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008103430607"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2009"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlab039"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/bi701427q"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c14233"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161243"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2024.02.009"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.11.025"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0496-3"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0435-3"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-021-00646-x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.105705"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0442-4"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.010"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.2c00184"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079469"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.3.491"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2018.03.027"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1039\/D0CP00450B"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.757425"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.4.1988"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2012.01.039"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305517110"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b01016"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ja205007j"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06388-y"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31226"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.01.048"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2014.10.012"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2006.10.012"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.4c00991"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ja507382j"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.4c05102"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ssnmr.2005.08.007"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/ja972655e"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.201800793"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1063\/1.462267"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.3c00194"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.1c03871"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2008.01.012"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2006.06.007"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2614(01)00791-6"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnmrs.2013.02.001"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-015-9924-9"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2018.03.014"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg2174"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.849979"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.01.022"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2011.06.012"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708354105"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00507"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-013-9741-y"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-010-9396-x"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.013"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","DOI":"10.1385\/1592598099","volume-title":"Protein NMR Techniques","author":"Downing A. K.","year":"2004"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2017.06.068"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/ja411577t"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c14703"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-55849-3"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34552-7"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43822-x"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c06971","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c06971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T08:13:15Z","timestamp":1755072795000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c06971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":63,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2025,8,13]]}},"alternative-id":["10.1021\/jacs.5c06971"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5c06971","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]}}}