{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:33:35Z","timestamp":1788838415595,"version":"build-2803163510"},"reference-count":73,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJCR24T1"],"award-info":[{"award-number":["JPMJCR24T1"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H02222"],"award-info":[{"award-number":["22H02222"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H02085"],"award-info":[{"award-number":["23H02085"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H05405"],"award-info":[{"award-number":["23H05405"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K02387"],"award-info":[{"award-number":["25K02387"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100025019","name":"Support for Pioneering Research Initiated by the Next Generation","doi-asserted-by":"publisher","award":["JPMJSP2136"],"award-info":[{"award-number":["JPMJSP2136"]}],"id":[{"id":"10.13039\/501100025019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2025,10,15]]},"DOI":"10.1021\/jacs.5c07422","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T03:18:23Z","timestamp":1759375103000},"page":"37065-37078","source":"Crossref","is-referenced-by-count":9,"title":["\u03b2-Fluorovinylsulfonamide as a Highly Reactivity- and Structure-Tunable Electrophile for Covalent Targeting of Proteins"],"prefix":"10.1021","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8085-9300","authenticated-orcid":true,"given":"Shunsuke","family":"Watanabe","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudai","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Hirose","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Mishiro-Sato","sequence":"additional","affiliation":[{"name":"Institute of Transformative Bio-Molecules (WPI-ITbM)","place":["Nagoya, Japan"]},{"name":"Nagoya University","place":["Nagoya, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Kano","sequence":"additional","affiliation":[{"name":"Institute of Transformative Bio-Molecules (WPI-ITbM)","place":["Nagoya, Japan"]},{"name":"Nagoya University","place":["Nagoya, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Sasaki-Tabata","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Kato","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Nishida","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2374-9896","authenticated-orcid":true,"given":"Naoya","family":"Shindo","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9440-8167","authenticated-orcid":true,"given":"Akio","family":"Ojida","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"},{"name":"CREST (Core Research for Evolutional Science and Technology, JST)","place":["Chiyodaku, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3410"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00220C"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01719"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00542-z"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c02134"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/jm020241c"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200600221"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2021.116386"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01825"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.925"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0204-3"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07490"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c10644"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08853"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c04695"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/jm500973a"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1694-1"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01180"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jm501412a"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00788"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00749"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.7b00553"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c06167"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00980"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/C6MD00017G"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/C5NJ00368G"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01002"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ci7002494"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b03394"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.0c09768"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.2c00114"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/ar00061a002"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1126\/science.178.4063.871"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010750108"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1080\/07328303.2017.1397681"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfluchem.2017.12.016"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)97493-8"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201200250"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc49572h"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/ol047996t"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2009.11.047"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201703179"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2208540119"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24081569"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/ja034490h"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.medp.2024.100008"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108477"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c02722"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/ci9002393"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC00408J"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.14694"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1126\/science1108367"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/ja401221b"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1582"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/ja8046188"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2020.129531"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/bi700605m"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2020.129800"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2020.07.014"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1124\/mol.116.107037"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.07.004"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16010016"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20200656"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51808-6"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-00676-4"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01019-1"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1817"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12874"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42632-5"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8838"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.668131"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08176-4"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c07422","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c07422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T08:43:31Z","timestamp":1760517811000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c07422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":73,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2025,10,15]]}},"alternative-id":["10.1021\/jacs.5c07422"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5c07422","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}