{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:00:14Z","timestamp":1790935214644,"version":"4.1.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"45","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21977054"],"award-info":[{"award-number":["21977054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22293032"],"award-info":[{"award-number":["22293032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374138"],"award-info":[{"award-number":["22374138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2025,11,12]]},"DOI":"10.1021\/jacs.5c09384","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T02:54:01Z","timestamp":1762224841000},"page":"41331-41341","source":"Crossref","is-referenced-by-count":6,"title":["Harnessing Multiplexed Proteolysis-Targeting Chimera for Comprehensive Influenza A Virus Targeting"],"prefix":"10.1021","volume":"147","author":[{"given":"Yang-Yang","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Centre for New Organic Matter, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, School of Medicine, and Frontiers Science Centre for Cell Responses","place":["Tianjin, P. R. China"]},{"name":"Nankai University","place":["Tianjin, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Centre for New Organic Matter, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, School of Medicine, and Frontiers Science Centre for Cell Responses","place":["Tianjin, P. R. China"]},{"name":"Nankai University","place":["Tianjin, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Sciences","place":["Wuhan, P. R. China"]},{"name":"Wuhan University","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Centre for New Organic Matter, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, School of Medicine, and Frontiers Science Centre for Cell Responses","place":["Tianjin, P. R. China"]},{"name":"Nankai University","place":["Tianjin, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Feng","sequence":"additional","affiliation":[{"name":"Tianjin Nankai District Centers for Disease Control and Prevention","place":["Tianjin, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9059-0654","authenticated-orcid":true,"given":"Zhi-Quan","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Sciences","place":["Wuhan, P. R. China"]},{"name":"Wuhan University","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3461-4014","authenticated-orcid":true,"given":"Zhi-Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Centre for New Organic Matter, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, School of Medicine, and Frontiers Science Centre for Cell Responses","place":["Tianjin, P. R. China"]},{"name":"Nankai University","place":["Tianjin, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7017-5725","authenticated-orcid":true,"given":"Dai-Wen","family":"Pang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Centre for New Organic Matter, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, School of Medicine, and Frontiers Science Centre for Cell Responses","place":["Tianjin, P. R. China"]},{"name":"Nankai University","place":["Tianjin, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1043-4238","authenticated-orcid":true,"given":"Shu-Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Centre for New Organic Matter, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, School of Medicine, and Frontiers Science Centre for Cell Responses","place":["Tianjin, P. R. China"]},{"name":"Nankai University","place":["Tianjin, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.05.009"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01381-4"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd3803"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3367"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2613"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.104545"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1638"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2205013119"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53945-1"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119115"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0900648"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1122947"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00371-6"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00193D"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00999-9"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellin.2023.100092"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellin.2022.100030"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29690-x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11429-w"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113814"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812632116"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s007050170002"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402766111"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nature14008"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg5953"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0075-7"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102951"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02102-20"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00138E"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.122924"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2024.102126"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401640"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202306808"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09255"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32216-0"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c09384","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c09384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T09:50:40Z","timestamp":1762941040000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c09384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":35,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2025,11,12]]}},"alternative-id":["10.1021\/jacs.5c09384"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5c09384","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]}}}