{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:47:33Z","timestamp":1792792053626,"version":"4.5.0"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"50","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0905800"],"award-info":[{"award-number":["2019YFA0905800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22107083"],"award-info":[{"award-number":["22107083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2188102"],"award-info":[{"award-number":["T2188102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["902025000045"],"award-info":[{"award-number":["902025000045"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Province","award":["2023SDYXS0002"],"award-info":[{"award-number":["2023SDYXS0002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2025,12,17]]},"DOI":"10.1021\/jacs.5c11823","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:34:53Z","timestamp":1760009693000},"page":"45951-45965","source":"Crossref","is-referenced-by-count":17,"title":["Chemical Evolution of Double Covalent Aptamers for Sustained Protein Degradation and Improved Cytotoxicity in NK-Cell-Mediated Tumor Therapy"],"prefix":"10.1021","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3104-6189","authenticated-orcid":true,"given":"Zhanhao","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemistry and Materials Science","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]},{"name":"Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)","place":["Hangzhou, China"]},{"name":"Chinese Academy of Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Qian","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)","place":["Hangzhou, China"]},{"name":"Chinese Academy of Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)","place":["Hangzhou, China"]},{"name":"Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang University of Technology","place":["Hangzhou, China"]},{"name":"College of Pharmaceutical Science","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Duan","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)","place":["Hangzhou, China"]},{"name":"Chinese Academy of Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3576-5742","authenticated-orcid":true,"given":"Yongrui","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)","place":["Hangzhou, China"]},{"name":"Chinese Academy of Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Fu","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)","place":["Hangzhou, China"]},{"name":"Chinese Academy of Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiu","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)","place":["Hangzhou, China"]},{"name":"Chinese Academy of Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulin","family":"Sha","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)","place":["Hangzhou, China"]},{"name":"Chinese Academy of Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)","place":["Hangzhou, China"]},{"name":"Chinese Academy of Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7095-5211","authenticated-orcid":true,"given":"Yajun","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)","place":["Hangzhou, China"]},{"name":"Chinese Academy of Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-1524","authenticated-orcid":true,"given":"Weihong","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]},{"name":"Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)","place":["Hangzhou, China"]},{"name":"Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering","place":["Shanghai, China"]},{"name":"Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2200121"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2014.08.003"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.199"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3141"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-017-0076"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213933109"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015004"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2014.49"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b13132"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC03747C"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217622"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00641"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz252"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00720B"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2020-0236"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1039\/D0MD00154F"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2017.05.008"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2021.102106"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.028"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2024.02.010"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02752"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202101174"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201204174"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC02631H"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.2c01263"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c03899"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC08109D"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.26.12220"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-8592(99)80014-9"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1656(00)00290-X"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01304-z"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2024.168742"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-024-02272-z"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad013"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1126\/science.adl2528"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2205796120"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.5c00196"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602615103"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200600532"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/1521-1878(200101)23:1<69::AID-BIES1009>3.0.CO;2-K"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/nature02677"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2775"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5380197"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23154"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac703"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c03630"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-3757"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b03442"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202002145"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201207063"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.665970"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c01186"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.770"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602615103"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c02509"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b13524"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c04928"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50315-y"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1055\/a-1437-8202"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201309399"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202425123"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308924"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC06016D"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c11823","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c11823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T09:23:06Z","timestamp":1765963386000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c11823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":65,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2025,12,17]]}},"alternative-id":["10.1021\/jacs.5c11823"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5c11823","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]}}}