{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:32:44Z","timestamp":1791289964150,"version":"4.3.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"44","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["IRT_15R27"],"award-info":[{"award-number":["IRT_15R27"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2019-I2M-5-074"],"award-info":[{"award-number":["2019-I2M-5-074"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-026"],"award-info":[{"award-number":["2021-I2M-1-026"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-3-001"],"award-info":[{"award-number":["2021-I2M-3-001"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2022-I2M-2-002"],"award-info":[{"award-number":["2022-I2M-2-002"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2022-RC350-04"],"award-info":[{"award-number":["2022-RC350-04"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2023-I2M-2-006"],"award-info":[{"award-number":["2023-I2M-2-006"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2023-I2M-QJ-010"],"award-info":[{"award-number":["2023-I2M-QJ-010"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2024-12M-ZH-009"],"award-info":[{"award-number":["2024-12M-ZH-009"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372002"],"award-info":[{"award-number":["82372002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Isotope Production Technology and Targeted Radiopharmaceuticals Research","award":["GSTWS2501"],"award-info":[{"award-number":["GSTWS2501"]}]},{"name":"Gansu Provincial Young Talents Program","award":["2025QNTD35"],"award-info":[{"award-number":["2025QNTD35"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2025,11,5]]},"DOI":"10.1021\/jacs.5c13695","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T08:55:04Z","timestamp":1761209704000},"page":"40751-40762","source":"Crossref","is-referenced-by-count":14,"title":["Development of Dual-Receptor Lysosome-Targeting Chimeras for Protein Degradation"],"prefix":"10.1021","volume":"147","author":[{"given":"Kun","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hange","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangzhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihong","family":"Ji","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuegong","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2549-629X","authenticated-orcid":true,"given":"Kuan","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0030-3234","authenticated-orcid":true,"given":"Hailong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4719-9921","authenticated-orcid":true,"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]},{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm908"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174621"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1072"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.056"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.015"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2938-9"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112205"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2021-0033"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2545-9"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08367"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00770-1"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01456-2"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07947-3"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00966-4"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/bc300084h"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.08.020"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1388"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2003.10.003"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2017.12.018"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29937"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1123-1"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.06.012"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.10.049"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.09.030"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S244712"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8040076"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52685-9"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-025-01924-1"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01272"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.017"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112377"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00558-1"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2692"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202003500"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.12.006"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf6249"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-1192"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202319232"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52975-2"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c13695","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c13695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T09:51:11Z","timestamp":1762336271000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c13695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":41,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2025,11,5]]}},"alternative-id":["10.1021\/jacs.5c13695"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5c13695","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,23]]}}}