{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:19:26Z","timestamp":1780975166903,"version":"3.54.1"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"51","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403400"],"award-info":[{"award-number":["2023YFC3403400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1308400"],"award-info":[{"award-number":["2024YFA1308400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374133"],"award-info":[{"award-number":["22374133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22404161"],"award-info":[{"award-number":["22404161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341104"],"award-info":[{"award-number":["82341104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017577","name":"Basic Public Welfare Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2025SDXT002"],"award-info":[{"award-number":["2025SDXT002"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017577","name":"Basic Public Welfare Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2025SDYXS0002"],"award-info":[{"award-number":["2025SDYXS0002"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017577","name":"Basic Public Welfare Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["WKJ-ZJ-2314"],"award-info":[{"award-number":["WKJ-ZJ-2314"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017577","name":"Basic Public Welfare Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["YXD23B0302"],"award-info":[{"award-number":["YXD23B0302"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hangzhou Institute of Medicine Chinese Academy of Sciences","award":["20242ZBS02"],"award-info":[{"award-number":["20242ZBS02"]}]},{"name":"Scientific Experiment Center, the Hangzhou Institute of Medicine, Chinese Academy of Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2025,12,24]]},"DOI":"10.1021\/jacs.5c16121","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:33:18Z","timestamp":1765438398000},"page":"47428-47442","source":"Crossref","is-referenced-by-count":1,"title":["pH-Isomerizable Acylhydrazone-Based Ionizable Lipids for Spleen-Targeted mRNA Vaccines"],"prefix":"10.1021","volume":"147","author":[{"given":"Xuqian","family":"Deng","sequence":"first","affiliation":[{"name":"Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo\/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]},{"name":"The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo\/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]},{"name":"The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]},{"name":"School of Materials Science and Engineering","place":["Tianjin, China"]},{"name":"Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Du","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]},{"name":"Cancer Center, Faculty of Health Sciences","place":["Macau, China"]},{"name":"University of Macau","place":["Macau, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Chi","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Cheng","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keli","family":"An","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6512-1511","authenticated-orcid":true,"given":"Penghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00937-y"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00346-0"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00902-1"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg9175"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00283-5"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-025-01980-7"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade6967"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-02085-z"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm0594"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-023-00586-2"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06063-y"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nature23003"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.10.014"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01163-9"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01160-y"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01091-9"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00894-z"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00859-3"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-00974-9"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08508-4"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00810-3"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00347-z"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-024-01084-x"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-024-02114-5"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08291-2"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c16326"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-025-02675-z"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0669-6"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c01389"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202500306"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2109256118"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-025-02556-5"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh9059"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-025-01933-0"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-01062-4"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-025-00844-1"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-00970-9"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00952A"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00146"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2020.08.007"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00288"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/ar500111f"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201305514"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS00642A"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-025-00847-2"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-024-01557-2"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c04331"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-025-02240-8"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01127D"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00822-2"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00689-z"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-023-00615-0"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00859-1"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06299-8"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.006"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00564-3"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01194-2"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00563-6"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c16121","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c16121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:04:50Z","timestamp":1768568690000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c16121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":59,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2025,12,24]]}},"alternative-id":["10.1021\/jacs.5c16121"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5c16121","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]}}}