{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:10:43Z","timestamp":1792725043978,"version":"4.5.0"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017291","name":"Zhongshan Science and Technology Bureau","doi-asserted-by":"publisher","award":["CXTD2022012"],"award-info":[{"award-number":["CXTD2022012"]}],"id":[{"id":"10.13039\/501100017291","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017670","name":"Bureau of Frontier Sciences and Education, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB1360000"],"award-info":[{"award-number":["XDB1360000"]}],"id":[{"id":"10.13039\/501100017670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["210634"],"award-info":[{"award-number":["210634"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["223107"],"award-info":[{"award-number":["223107"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["302632"],"award-info":[{"award-number":["302632"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22PJ1415600"],"award-info":[{"award-number":["22PJ1415600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22207114"],"award-info":[{"award-number":["22207114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477143"],"award-info":[{"award-number":["22477143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/R007195\/1"],"award-info":[{"award-number":["BB\/R007195\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/W016613\/1"],"award-info":[{"award-number":["BB\/W016613\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C35050\/A22284"],"award-info":[{"award-number":["C35050\/A22284"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["OCENW.KLEIN.497"],"award-info":[{"award-number":["OCENW.KLEIN.497"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2026,2,4]]},"DOI":"10.1021\/jacs.5c17532","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:07:33Z","timestamp":1767892053000},"page":"4270-4282","source":"Crossref","is-referenced-by-count":6,"title":["Chemical Synthesis of Native ADP-Ribosylated Oligonucleotides Enables Analysis of DNA ADP-Ribosylation Hydrolase Specificity"],"prefix":"10.1021","volume":"148","author":[{"given":"Li","family":"Tang","sequence":"first","affiliation":[{"name":"Carbohydrate-Based Drug Research Center","place":["Shanghai, China"]},{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","place":["Shanghai, China"]},{"name":"Zhongshan Institute for Drug Discovery","place":["Zhongshan, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lu","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology","place":["Oxford, U.K."]},{"name":"University of Oxford","place":["Oxford, U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke L. A. M.","family":"van der Heijden","sequence":"additional","affiliation":[{"name":"Bio-Organic Synthesis, Leiden Institute of Chemistry","place":["Leiden, The Netherlands"]},{"name":"Leiden University","place":["Leiden, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery","place":["Zhongshan, China"]},{"name":"Guangzhou University of Chinese Medicine","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery","place":["Zhongshan, China"]},{"name":"School of Chinese Materia Medica","place":["Nanjing, China"]},{"name":"Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico J.","family":"Meeuwenoord","sequence":"additional","affiliation":[{"name":"Bio-Organic Synthesis, Leiden Institute of Chemistry","place":["Leiden, The Netherlands"]},{"name":"Leiden University","place":["Leiden, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery","place":["Zhongshan, China"]},{"name":"School of Pharmaceutical Sciences","place":["Guangzhou, China"]},{"name":"Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongxing","family":"Yu","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery","place":["Zhongshan, China"]},{"name":"School of Pharmaceutical Sciences","place":["Guangzhou, China"]},{"name":"Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenrong","family":"Chen","sequence":"additional","affiliation":[{"name":"Carbohydrate-Based Drug Research Center","place":["Shanghai, China"]},{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","place":["Shanghai, China"]},{"name":"Zhongshan Institute for Drug Discovery","place":["Zhongshan, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Schuller","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology","place":["Oxford, U.K."]},{"name":"University of Oxford","place":["Oxford, U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitri V.","family":"Filippov","sequence":"additional","affiliation":[{"name":"Bio-Organic Synthesis, Leiden Institute of Chemistry","place":["Leiden, The Netherlands"]},{"name":"Leiden University","place":["Leiden, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Ahel","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology","place":["Oxford, U.K."]},{"name":"University of Oxford","place":["Oxford, U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1229-7908","authenticated-orcid":true,"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Carbohydrate-Based Drug Research Center","place":["Shanghai, China"]},{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","place":["Shanghai, China"]},{"name":"Zhongshan Institute for Drug Discovery","place":["Zhongshan, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Guangzhou University of Chinese Medicine","place":["Guangdong, China"]},{"name":"School of Chinese Materia Medica","place":["Nanjing, China"]},{"name":"Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16142"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2021.103144"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.030"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1101\/gad.334631.119"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.06.013"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nature10404"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.7554\/elife.28533"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.07.010"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2025.103863"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.04.028"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00599C"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2366"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/ja00432a071"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/4.2.415"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202002295"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.10.026"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.604618"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714812115"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.023"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.07.044"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.12.033"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.11.014"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03825-4"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01153-5"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s44318-025-00451-y"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051628898"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.221444598"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.04.023"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08102-8"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf069"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.08.015"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw675"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14297"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz305"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac711"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-024-01279-6"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.51"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113113"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33731-w"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adi2687"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202100337"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB00501C"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC02340C"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC05755E"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24723-3"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201710527"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.31.3074"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/ol400929c"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB02334G"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1080\/15257770008033052"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b01742"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20141554"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.3390\/toxins16050208"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab771"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.17.5603"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38793-y"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46649-2"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2918"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201412283"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.721894"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2022.08.002"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab136"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.01.014"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.11.038"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky792"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c17532","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c17532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:49:23Z","timestamp":1770220163000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c17532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2,4]]}},"alternative-id":["10.1021\/jacs.5c17532"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5c17532","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]}}}