{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:55:08Z","timestamp":1790873708459,"version":"4.1.0"},"reference-count":125,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cla Caixa\u201d foundation"},{"name":"Fundaluce-FARPE patients' foundation"},{"name":"EU Horizon 2020 Framework Programme for Research and Innovation"},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Instituto de Salud Carlos III (ISCIII)"},{"name":"Agency for Management of University and Research Grants of the Government of Catalonia"},{"name":"Fonds Europ\u00e9en de D\u00e9veloppement \u00c9conomique et R\u00e9gional (FEDER) funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Blinding diseases due to the degeneration of photoreceptors (PhRs), such as geographic atrophy (GA) secondary to dry age-related macular degeneration and retinitis pigmentosa (RP), leave the rest of the retinal circuitry largely intact, albeit unable to respond to light. Gene therapy has been able to revert PhR degeneration, but it can be applied only to a rare mutation affecting a small subset of RP patients. Alternatively, implanted electronic retinal prostheses aim at a larger population by electrically stimulating surviving neurons. However, the treatment is invasive and costly and provides limited resolution. Photopharmacology can develop photoswitchable small molecules to restore vision impairment by conferring light sensitivity to ion channels that are widely expressed in the remaining inner retinal neurons, and a first-in-human clinical trial is ongoing. Here, we have developed novel photoswitchable small-molecule ligands of metabotropic glutamate 6 (mGlu6) receptors, which are located exclusively at the dendrites of ON bipolar cells (postsynaptic to PhRs) and can leverage a privileged position to mimic physiological signals in the remnant retinal circuit. These photoswitchable ligands (prosthe6) thus act as \u201cmolecular prostheses\u201d that can restore the light input to the retina via upstream-targeted control of the circuit after PhR degeneration. Prosthe6 compounds are allosteric, drug-like, water-soluble, and display outstanding in vitro properties including full efficacy, nanomolar potency, fast deactivation in ambient white light, and fast reactivation in the dark. In vivo experiments show that they readily recover the saccadic eye movements of blinded zebrafish larvae and restore the innate light-avoidance behavior in the mouse models of blindness (GA and RP). These effects are mediated by mGlu6 receptors in vivo. In addition, at least two compounds (prosthe6-12 and -15) can restore sight by topical administration and display promising safety properties to become potential drug candidates for sight restoration in patients with degenerative blinding diseases.<\/jats:p>","DOI":"10.1021\/jacs.5c18611","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:55:03Z","timestamp":1784120103000},"page":"31701-31715","source":"Crossref","is-referenced-by-count":2,"title":["Restoration\nof Saccadic Eye Movements and Visually\nGuided Behavior in Ambient White Light with Photoswitchable Small\nMolecules"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8854-6782","authenticated-orcid":true,"given":"Rosalba","family":"Sortino","sequence":"first","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]},{"name":"University of Barcelona Doctorate Program , ,","place":["Barcelona, Spain, 08028"]},{"name":"CIBER-BBN , Avenida Monforte de Lemos, 3-5, Pabello\u0301n 11, Planta 0 , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleix","family":"Gonza\u0301lez-Di\u0301ez","sequence":"additional","affiliation":[{"name":"Institute for Advanced Chemistry of Catalonia (IQAC\u2212CSIC) , , Carrer de Jordi Girona, 20 , ,","place":["Barcelona, Spain, 08034"]},{"name":"Institute Ramo\u0301n y Cajal of Health Research (IRYCIS) , Ctra. Colmenar Viejo , , ,","place":["Fuencarral-El Pardo, Madrid, Spain, 28034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Milla-Navarro","sequence":"additional","affiliation":[{"name":"University of Alcala\u0301 de Henares (UAH) , Pl. de San Diego, s\/n , , ,","place":["Alcala\u0301 de Henares, Madrid, Spain, 28801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7459-6749","authenticated-orcid":true,"given":"Joaqui\u0301n","family":"Marti\u0301nez-Tambella","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]},{"name":"University of Barcelona Doctorate Program , ,","place":["Barcelona, Spain, 08028"]},{"name":"CIBER-BBN , Avenida Monforte de Lemos, 3-5, Pabello\u0301n 11, Planta 0 , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vi\u0301ctor","family":"Paleo-Garci\u0301a","sequence":"additional","affiliation":[{"name":"University of Alcala\u0301 de Henares (UAH) , Pl. de San Diego, s\/n , , ,","place":["Alcala\u0301 de Henares, Madrid, Spain, 28801"]},{"name":"Institute Ramo\u0301n y Cajal of Health Research (IRYCIS) , Ctra. Colmenar Viejo , , ,","place":["Fuencarral-El Pardo, Madrid, Spain, 28034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-096X","authenticated-orcid":true,"given":"Eric","family":"Calatayud","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"de Saralegui","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekin","family":"Opar","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]},{"name":"University of Barcelona Doctorate Program , ,","place":["Barcelona, Spain, 08028"]},{"name":"CIBER-BBN , Avenida Monforte de Lemos, 3-5, Pabello\u0301n 11, Planta 0 , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u0300lvar","family":"Claparols","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josecarlo A.","family":"Quintanilla","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Marti\u0301nez-Soler","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Riefolo","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]},{"name":"University of Barcelona Doctorate Program , ,","place":["Barcelona, Spain, 08028"]},{"name":"CIBER-BBN , Avenida Monforte de Lemos, 3-5, Pabello\u0301n 11, Planta 0 , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-3859","authenticated-orcid":true,"given":"Carlo","family":"Matera","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]},{"name":"CIBER-BBN , Avenida Monforte de Lemos, 3-5, Pabello\u0301n 11, Planta 0 , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1126-4138","authenticated-orcid":true,"given":"Jordi","family":"Hernando","sequence":"additional","affiliation":[{"name":"Autonomous University of Barcelona (UAB) , Plac\u0327a Ci\u0301vica , , ,","place":["Bellaterra, Barcelona, Spain, 08193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre M. J.","family":"Gomila","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]},{"name":"University of Barcelona Doctorate Program , ,","place":["Barcelona, Spain, 08028"]},{"name":"CIBER-BBN , Avenida Monforte de Lemos, 3-5, Pabello\u0301n 11, Planta 0 , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Pe\u0301rez-Batlle","sequence":"additional","affiliation":[{"name":"Fundacio\u0301 Eduard Soler , Avinguda Eduard Soler, 1 , , ,","place":["Ripoll, Girona, Spain, 17500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Pereira","sequence":"additional","affiliation":[{"name":"Fundacio\u0301 Eduard Soler , Avinguda Eduard Soler, 1 , , ,","place":["Ripoll, Girona, Spain, 17500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nu\u0301ria","family":"Camarero","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]},{"name":"CIBER-BBN , Avenida Monforte de Lemos, 3-5, Pabello\u0301n 11, Planta 0 , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Serra","sequence":"additional","affiliation":[{"name":"Institute for Advanced Chemistry of Catalonia (IQAC\u2212CSIC) , , Carrer de Jordi Girona, 20 , ,","place":["Barcelona, Spain, 08034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8830-0494","authenticated-orcid":true,"given":"Xavier","family":"Go\u0301mez-Santacana","sequence":"additional","affiliation":[{"name":"Institute for Advanced Chemistry of Catalonia (IQAC\u2212CSIC) , , Carrer de Jordi Girona, 20 , ,","place":["Barcelona, Spain, 08034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-4827","authenticated-orcid":true,"given":"Amadeu","family":"Llebaria","sequence":"additional","affiliation":[{"name":"Institute for Advanced Chemistry of Catalonia (IQAC\u2212CSIC) , , Carrer de Jordi Girona, 20 , ,","place":["Barcelona, Spain, 08034"]},{"name":"Institut de Qui\u0301mica Avanc\u0327ada de Catalunya (IQAC\u2212CSIC) , , Carrer de Jordi Girona, 20 , ,","place":["Barcelona, Spain, 08034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Rovira","sequence":"additional","affiliation":[{"name":"Institute for Advanced Chemistry of Catalonia (IQAC\u2212CSIC) , , Carrer de Jordi Girona, 20 , ,","place":["Barcelona, Spain, 08034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"de la Villa","sequence":"additional","affiliation":[{"name":"University of Alcala\u0301 de Henares (UAH) , Pl. de San Diego, s\/n , , ,","place":["Alcala\u0301 de Henares, Madrid, Spain, 28801"]},{"name":"Institute Ramo\u0301n y Cajal of Health Research (IRYCIS) , Ctra. Colmenar Viejo , , ,","place":["Fuencarral-El Pardo, Madrid, Spain, 28034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-5577","authenticated-orcid":true,"given":"Pau","family":"Gorostiza","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Science and Technology , , Carrer de Baldiri Reixac, 10, 12 , ,","place":["Barcelona, Spain, 08028"]},{"name":"CIBER-BBN , Avenida Monforte de Lemos, 3-5, Pabello\u0301n 11, Planta 0 , ,","place":["Madrid, Spain, 28029"]},{"name":"Catalan Institution for Research and Advanced Studies (ICREA) , ,","place":["Barcelona, Spain, 08010"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2026080511111036000_cit1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3389\/fncir.2014.00079","article-title":"Mapping arealisation of the visual cortex of non-primate\nspecies: lessons for development and evolution","volume":"8","author":"Homman-Ludiye","year":"2014","journal-title":"Front. Neural Circuits"},{"issue":"11","key":"2026080511111036000_cit2","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1001\/jamaophthalmol.2019.3537","article-title":"Evaluating\nWhether Sight Is the Most Valued Sense","volume":"137","author":"Enoch","year":"2019","journal-title":"JAMA\nOphthalmol."},{"issue":"2","key":"2026080511111036000_cit3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1001\/jama.2023.26074","article-title":"Age-Related Macular Degeneration:\nA Review","volume":"331","author":"Fleckenstein","year":"2024","journal-title":"JAMA"},{"issue":"2","key":"2026080511111036000_cit4","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.1016\/S2214-109X(20)30489-7","article-title":"Causes of blindness and vision impairment in 2020 and\ntrends over 30 years, and prevalence of avoidable blindness in relation\nto VISION 2020: the Right to Sight: an analysis for the Global Burden\nof Disease Study","volume":"9","author":"The Vision Loss Expert Group (VLEG) is a global coalition of researchers partnering with the Global Burden of Disease (GBD) study to track vision impairment and blindness.","year":"2021","journal-title":"Lancet Global Health"},{"key":"2026080511111036000_cit5","unstructured":"Cieza, A. K. S.; Kocur, I.; Mccoy, M.; Mariotti, S. P.\n          World\nReport on Vision; 20 March 2024; World Health\nOrganization: Geneva, Switzerland, 2019. https:\/\/iris.who.int\/bitstream\/handle\/10665\/328717\/9789241516570-eng.pdf?sequence=18."},{"issue":"5","key":"2026080511111036000_cit6a","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3390\/antiox13050568","article-title":"Antioxidants\nand\nMechanistic Insights for Managing Dry Age-Related Macular Degeneration","volume":"13","author":"Basyal","year":"2024","journal-title":"Antioxidants"},{"issue":"6","key":"2026080511111036000_cit6b","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s40123-025-01144-9","article-title":"Clinical Outcomes\nof Treatment of Geographic Atrophy: A Narrative Review","volume":"14","author":"Nissen","year":"2025","journal-title":"Ophthalmol. Ther."},{"issue":"1","key":"2026080511111036000_cit7a","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/ng0501-92","article-title":"Gene\ntherapy restores vision in a canine model of childhood blindness","volume":"28","author":"Acland","year":"2001","journal-title":"Nat. Genet."},{"issue":"3","key":"2026080511111036000_cit7b","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41591-020-0763-1","article-title":"Initial results from a first-in-human gene\ntherapy trial on X-linked retinitis pigmentosa caused by mutations\nin RPGR","volume":"26","author":"Cehajic-Kapetanovic","year":"2020","journal-title":"Nat. Med."},{"issue":"2","key":"2026080511111036000_cit8a","doi-asserted-by":"publisher","first-page":"685","DOI":"10.3390\/pharmaceutics15020685","article-title":"Retinitis Pigmentosa:\nNovel Therapeutic\nTargets and Drug Development","volume":"15","author":"Wu","year":"2023","journal-title":"Pharmaceutics"},{"key":"2026080511111036000_cit8b","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.2147\/OPTH.S370032","article-title":"Current and Future Treatment of Retinitis Pigmentosa","volume":"16","author":"Cross","year":"2022","journal-title":"Clin. Ophthalmol."},{"issue":"8","key":"2026080511111036000_cit9","doi-asserted-by":"publisher","first-page":"a041525","DOI":"10.1101\/cshperspect.a041525","article-title":"Electronic\nRetinal Prostheses","volume":"13","author":"Palanker","year":"2023","journal-title":"Cold Spring Harb. Perspect.\nMed."},{"key":"2026080511111036000_cit10","article-title":"Retinal Prostheses","volume-title":"Webvision:\nThe Organization of the Retina and Visual\nSystem","author":"Cohen","year":"1995"},{"issue":"2","key":"2026080511111036000_cit11a","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s12152-024-09549-2","article-title":"What Happens After a Neural Implant Study? Neuroethics Expert Workshop\non Post-Trial Obligations","volume":"17","author":"Dasgupta","year":"2024","journal-title":"Neuroethics"},{"issue":"1","key":"2026080511111036000_cit11b","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s40942-023-00498-1","article-title":"An update on visual prosthesis","volume":"9","author":"Ramirez","year":"2023","journal-title":"Int. J. Retina Vitreous"},{"issue":"3","key":"2026080511111036000_cit12a","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41684-018-0003-1","article-title":"New technologies for\ndeveloping second generation retinal prostheses","volume":"47","author":"Benfenati","year":"2018","journal-title":"Lab. Anim."},{"issue":"8","key":"2026080511111036000_cit12b","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/s41565-020-0696-3","article-title":"Subretinally\ninjected semiconducting polymer nanoparticles rescue vision in a rat\nmodel of retinal dystrophy","volume":"15","author":"Maya-Vetencourt","year":"2020","journal-title":"Nat. Nanotechnol."},{"issue":"11","key":"2026080511111036000_cit13a","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007679","article-title":"Visual properties of transgenic rats harboring the channelrhodopsin-2\ngene regulated by the thy-1.2 promoter","volume":"4","author":"Tomita","year":"2009","journal-title":"PLoS\nOne"},{"issue":"4","key":"2026080511111036000_cit13b","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41551-021-00836-4","article-title":"Bioengineering strategies for restoring vision","volume":"7","author":"Cehajic-Kapetanovic","year":"2023","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"2026080511111036000_cit14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00417-021-05477-6","article-title":"Restoring vision using optogenetics\nwithout being blind\nto the risks","volume":"260","author":"Harris","year":"2022","journal-title":"Graefe\u2019s Arch. Clin. Exp.\nOphthalmol."},{"key":"2026080511111036000_cit15a","unstructured":"(a)\n          \n          Efficacy and Safety of\nMCO-010 Optogenetic\nTherapy in Adults With Retinitis Pigmentosa RESTORE. https:\/\/classic.clinicaltrials.gov\/show\/NCT04945772."},{"key":"2026080511111036000_cit15b","unstructured":"(b)\n          \n          Safety and Efficacy Study of Novel Gene Therapy ZM-02 for Retinitis\nPigmentosa Patients. https:\/\/classic.clinicaltrials.gov\/show\/NCT06292650."},{"key":"2026080511111036000_cit15c","unstructured":"(c)\n          \n          A Long-Term Follow-Up Study in Subjects Who\nReceived vMCO-I Administered Via Intravitreal Injection. https:\/\/classic.clinicaltrials.gov\/show\/NCT05921162."},{"key":"2026080511111036000_cit15d","unstructured":"(d)\n          \n          Dose-Escalation Study to Evaluate the Safety and Tolerability of\nIntravitreal vMCO-I in Patients With Advanced Retinitis Pigmentosa. https:\/\/classic.clinicaltrials.gov\/show\/NCT04919473."},{"key":"2026080511111036000_cit15","unstructured":"Non-Interventional\nLong Term Follow-up Study of Participants Previously Enrolled in the\nRESTORE Study. https:\/\/classic.clinicaltrials.gov\/show\/NCT06162585."},{"key":"2026080511111036000_cit16","unstructured":"RST-001 Phase I\/II Trial for Advanced Retinitis\nPigmentosa. https:\/\/classic.clinicaltrials.gov\/show\/NCT02556736."},{"key":"2026080511111036000_cit17","unstructured":"Dose-escalation Study to Evaluate the Safety\nand Tolerability of\nGS030 in Subjects With Retinitis Pigmentosa. https:\/\/classic.clinicaltrials.gov\/show\/NCT03326336."},{"issue":"7","key":"2026080511111036000_cit18","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/s41591-021-01351-4","article-title":"Partial recovery of\nvisual function in a blind patient after optogenetic therapy","volume":"27","author":"Sahel","year":"2021","journal-title":"Nat. Med."},{"issue":"2","key":"2026080511111036000_cit19","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.neuron.2012.05.022","article-title":"Photochemical restoration of visual responses\nin blind mice","volume":"75","author":"Polosukhina","year":"2012","journal-title":"Neuron"},{"issue":"7","key":"2026080511111036000_cit20","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/mt.2011.103","article-title":"LiGluR restores visual responses\nin rodent models of inherited blindness","volume":"19","author":"Caporale","year":"2011","journal-title":"Mol.\nTher."},{"key":"2026080511111036000_cit21","doi-asserted-by":"publisher","first-page":"12221","DOI":"10.1038\/ncomms12221","article-title":"Optical control of endogenous\nreceptors and cellular excitability using targeted covalent photoswitches","volume":"7","author":"Izquierdo-Serra","year":"2016","journal-title":"Nat. Commun."},{"issue":"21","key":"2026080511111036000_cit22","doi-asserted-by":"publisher","first-page":"10748","DOI":"10.1021\/acs.chemrev.7b00723","article-title":"Restoring Vision\nto the Blind with Chemical Photoswitches","volume":"118","author":"Tochitsky","year":"2018","journal-title":"Chem.\nRev."},{"key":"2026080511111036000_cit23","doi-asserted-by":"publisher","first-page":"102259","DOI":"10.1016\/j.coph.2022.102259","article-title":"Photopharmacology for vision restoration","volume":"65","author":"Berry","year":"2022","journal-title":"Curr. Opin. Pharmacol."},{"issue":"10","key":"2026080511111036000_cit24","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1038\/s41591-022-01996-9","article-title":"Author Correction:\nRegenerative and restorative medicine for eye disease","volume":"28","author":"Van Gelder","year":"2022","journal-title":"Nat. Med."},{"key":"2026080511111036000_cit25","unstructured":"A Phase II Study of Intravitreal KIO-301\nin Patients With Late-stage\nRetinitis Pigmentosa (ABACUS-2). https:\/\/clinicaltrials.gov\/study\/NCT06628947."},{"key":"2026080511111036000_cit26","doi-asserted-by":"publisher","first-page":"45487","DOI":"10.1038\/srep45487","article-title":"Restoring\nvisual function to the blind retina with a potent, safe and long-lasting\nphotoswitch","volume":"7","author":"Tochitsky","year":"2017","journal-title":"Sci. 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