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These processes are predicated on the hydroxyl-directed formation of an Ir-enolate. Inter- and intramolecular processes are feasible, with the latter offering stereocontrolled access to carbocycles bearing two new stereocenters. The intramolecular processes constitute rare examples of alkene-based Conia-ene reactions that are enantio- and diastereoselective.<\/jats:p>","DOI":"10.1021\/jacs.5c19724","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:53:32Z","timestamp":1768910012000},"page":"3911-3917","source":"Crossref","is-referenced-by-count":0,"title":["Iridium-Catalyzed Stereoselective\n\u03b1-Alkylation\nof \u03b1-Hydroxy Ketones with Minimally Polarized Alkenes"],"prefix":"10.1021","volume":"148","author":[{"given":"Yihong","family":"Wang","sequence":"first","affiliation":[{"name":"University of Liverpool , , Crown Street , ,","place":["Liverpool, United Kingdom, L69 7ZD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglin","family":"Hong","sequence":"additional","affiliation":[{"name":"University of Liverpool , , Crown Street , ,","place":["Liverpool, United Kingdom, L69 7ZD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig M.","family":"Robertson","sequence":"additional","affiliation":[{"name":"University of Liverpool , , Crown Street , ,","place":["Liverpool, United Kingdom, L69 7ZD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Mudd","sequence":"additional","affiliation":[{"name":"University of Liverpool , , Crown Street , ,","place":["Liverpool, United Kingdom, L69 7ZD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-8221","authenticated-orcid":true,"given":"John F.","family":"Bower","sequence":"additional","affiliation":[{"name":"University of Liverpool , , Crown Street , ,","place":["Liverpool, United Kingdom, L69 7ZD"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"2026090713180326500_cit1","unstructured":"Throughout the manuscript,\n\u201calkenes\u201d refers to \u201csimple alkenes\u201d,\nrather than more highly activated \u03c0-unsaturated systems, such\nas dienes or allenes."},{"key":"2026090713180326500_cit2a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202504477","article-title":"\u03b2-Quaternary \u03b1-amino\nacids via iridium-catalyzed branched and enantioselective hydroalkylation\nof 1,1-disubstituted styrenes","volume":"64","author":"Hong","year":"2025","journal-title":"Angew. 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