{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:07:34Z","timestamp":1791461254197,"version":"4.3.4"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023B0303000004"],"award-info":[{"award-number":["2023B0303000004"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22273046"],"award-info":[{"award-number":["22273046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22375226"],"award-info":[{"award-number":["22375226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32261143727"],"award-info":[{"award-number":["32261143727"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52433005"],"award-info":[{"award-number":["52433005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangzhou Basic and Applied Basic Research Project","award":["2025A04J5268"],"award-info":[{"award-number":["2025A04J5268"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2026,3,11]]},"DOI":"10.1021\/jacs.5c20438","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T19:33:14Z","timestamp":1772479994000},"page":"9596-9607","source":"Crossref","is-referenced-by-count":5,"title":["Unraveling the Role of Ionizable Lipid Isomerism in Modulating Lipid Nanoparticles for mRNA Delivery"],"prefix":"10.1021","volume":"148","author":[{"given":"Zepeng","family":"He","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-6961","authenticated-orcid":true,"given":"Zhijia","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6741-5399","authenticated-orcid":true,"given":"Taisen","family":"Zuo","sequence":"additional","affiliation":[{"name":"Institute of High Energy Physics (IHEP)","place":["Beijing, China"]},{"name":"Chinese Academy of Sciences (Cas)","place":["Beijing, China"]},{"name":"Spallation Neutron Source Science Center","place":["Dongguan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhen","family":"Chu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheqi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueer","family":"Ge","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gege","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Life and Health Technology","place":["Dongguan, China"]},{"name":"Dongguan University of Technology","place":["Dongguan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of High Energy Physics (IHEP)","place":["Beijing, China"]},{"name":"Chinese Academy of Sciences (Cas)","place":["Beijing, China"]},{"name":"Spallation Neutron Source Science Center","place":["Dongguan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0350-7475","authenticated-orcid":true,"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Translational Medical Center of Huaihe Hospital","place":["Kaifeng, China"]},{"name":"Henan University","place":["Kaifeng, China"]},{"name":"State Key Laboratory of Antiviral Drugs","place":["Zhengzhou, China"]},{"name":"Henan University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2943-5465","authenticated-orcid":true,"given":"Yi","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-4977","authenticated-orcid":true,"given":"Lixin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8718-4110","authenticated-orcid":true,"given":"He","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of High Energy Physics (IHEP)","place":["Beijing, China"]},{"name":"Chinese Academy of Sciences (Cas)","place":["Beijing, China"]},{"name":"Spallation Neutron Source Science Center","place":["Dongguan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2843-5543","authenticated-orcid":true,"given":"Yongming","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Functional Biomaterials Engineering Technology Research Center","place":["Guangzhou, China"]},{"name":"Sun Yat-Sen University","place":["Guangzhou, China"]},{"name":"College of Chemistry and Molecular Science","place":["Zhengzhou, China"]},{"name":"Henan University","place":["Zhengzhou, China"]},{"name":"State Key Laboratory of Antiviral Drugs","place":["Zhengzhou, China"]},{"name":"Henan University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307079"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-00977-6"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01294-2"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00358-0"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27493-0"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00544"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00601"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401445"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2612"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400199"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.7150\/thno.87316"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00244"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c10670"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c13569"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310401"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202106727"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/la104590k"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02441-2"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c10064"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.giant.2024.100329"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1720542115"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201203263"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2691"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2309472120"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00859-3"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-022-00511-y"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.85"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0669-6"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c02415"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-022-00755-x"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0247-3"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1039\/D5BM00738K"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59136-z"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-024-01867-3"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2409572122"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2025.11.032"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-025-01422-8"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c20438","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c20438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:49:14Z","timestamp":1773218954000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c20438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,3,11]]}},"alternative-id":["10.1021\/jacs.5c20438"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5c20438","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]}}}