{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:55:38Z","timestamp":1793498138782,"version":"4.5.0"},"reference-count":103,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss National Science Foundation (SNSF)","award":["180541"],"award-info":[{"award-number":["180541"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2026,2,4]]},"DOI":"10.1021\/jacs.5c22321","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:32:43Z","timestamp":1768966363000},"page":"4754-4765","source":"Crossref","is-referenced-by-count":9,"title":["A Ratiometric pH Sensor for Gram-Positive and Gram-Negative Bacteria"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1774-7288","authenticated-orcid":true,"given":"Dorothea","family":"Kossmann","sequence":"first","affiliation":[{"name":"Department of Chemistry","place":["Zurich, Switzerland"]},{"name":"University of Zurich","place":["Zurich, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Biomedicine","place":["Basel, Switzerland"]},{"name":"University of Basel","place":["Basel, Switzerland"]},{"name":"Swiss Institute of Bioinformatics","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Biomedicine","place":["Basel, Switzerland"]},{"name":"University of Basel","place":["Basel, Switzerland"]},{"name":"Division of Infection Diseases","place":["Basel, Switzerland"]},{"name":"University Hospital Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8558-2828","authenticated-orcid":true,"given":"Pablo","family":"Rivera-Fuentes","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Zurich, Switzerland"]},{"name":"University of Zurich","place":["Zurich, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)74210-3"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux004"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202051034"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-017-0036-2"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-13-258"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20135022"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099390"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2019.03.007"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110504"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2004.11.005"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-023-01566-w"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02212-22"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.34"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2008.00156.x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/srep41284"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72979-4"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1485"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034055"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9112277"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2549"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6976.12076"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13439"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv388"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1128\/aem.63.11.4210-4215.1997"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2005.09.010"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4157(81)90004-6"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6271"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.04.013"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/35021074"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00909-21"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/28190"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(00)76468-X"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40560-3"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2018.01.008"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1039\/b903641p"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.13439"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.8.4145-4147.2002"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00157"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.4c00060"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00719H"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.02.014"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13598"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3791\/53408"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.600033"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1997.2466"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00595-9"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.7039-7048.2000"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.4041-4047.1999"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.5.2501-2510.2005"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02831-14"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/nature22308"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB00553K"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/ja400337p"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2021.129711"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201608779"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/cr60293a001"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c02591"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/j100248a024"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/cr00002a004"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1039\/c4ra01598c"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc15721c"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201207701"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA02579J"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1039\/C9NJ03846A"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201800485"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b04485"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00159607"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.7.1990-1995.1996"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad3558"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb01453.x"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.6.1579-1590.2004"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1128\/aem.51.4.703-709.1986"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00201"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.3389\/frans.2023.1258558"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(91)90212-O"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.3390\/chemosensors10100411"},{"key":"ref78\/cit78","volume-title":"The Molecular Probes\u00ae Handbook, A Guide to Fluorescent Probes and Labeling Technologies","author":"Iain J.","year":"2010"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR07659J"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.376584"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1021\/nn5041476"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1039\/C9NJ03744F"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1021\/cbmi.3c00110"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.8b07362"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c06428"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1021\/jp100371s"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-017-9724-x"},{"key":"ref88\/cit88","doi-asserted-by":"crossref","DOI":"10.6028\/NBS.CIRC.514","volume-title":"Table of Dielectric Constants of Pure Liquids","author":"Maryott A. A.","year":"1951"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.95.1.189"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1117\/12.251737"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1007\/BF00732054"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(97)00068-8"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01456.x"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2008.04.011"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb00379.x"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100050"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.3c00541"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2019.0076"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01482-15"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1039\/B917876G"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.24.8407-8423.2004"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.4.1085-1092.1996"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c22321","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c22321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:49:06Z","timestamp":1770220146000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c22321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":103,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2,4]]}},"alternative-id":["10.1021\/jacs.5c22321"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5c22321","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.09.09.675137","asserted-by":"object"}]},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]}}}