{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:06:15Z","timestamp":1789621575463,"version":"build-2803163510"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20591"],"award-info":[{"award-number":["U25A20591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2026,4,1]]},"DOI":"10.1021\/jacs.5c22730","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T05:52:46Z","timestamp":1774245166000},"page":"13128-13139","source":"Crossref","is-referenced-by-count":3,"title":["Adaptive Pore Deformation in Metal\u2013Organic Framework Nanosheets for Enhanced Enzymatic Catalysis"],"prefix":"10.1021","volume":"148","author":[{"given":"Huangsheng","family":"Yang","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry","place":["Guangzhou, China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Multi-scale Porous Materials Center, Institute of Advanced Interdisciplinary Studies & School of Chemistry and Chemical Engineering","place":["Chongqing, China"]},{"name":"Chongqing University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Cai","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry","place":["Guangzhou, China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3088-3097","authenticated-orcid":true,"given":"Yuhong","family":"Lin","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry","place":["Guangzhou, China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8605-4848","authenticated-orcid":true,"given":"Yong","family":"Shen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry","place":["Guangzhou, China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-9535","authenticated-orcid":true,"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)","place":["Zhuhai, China"]},{"name":"Sun Yat-sen University","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujian","family":"Shen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry","place":["Guangzhou, China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjing","family":"Tong","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry","place":["Guangzhou, China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, the Third Affiliated Hospital of Southern Medical University","place":["Guangzhou, China"]},{"name":"Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)","place":["Zhuhai, China"]},{"name":"Sun Yat-sen University","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3917-8343","authenticated-orcid":true,"given":"Hang","family":"Xing","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo-\/Bio-Sensing and Chemometrics, School of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6939-9975","authenticated-orcid":true,"given":"Fang","family":"Zhu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry","place":["Guangzhou, China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-1082","authenticated-orcid":true,"given":"Siming","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital","place":["Guangzhou, China"]},{"name":"Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-7675","authenticated-orcid":true,"given":"Guosheng","family":"Chen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry","place":["Guangzhou, China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, China"]},{"name":"School of Chemical Engineering and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)","place":["Zhuhai, China"]},{"name":"Sun Yat-sen University","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-9884","authenticated-orcid":true,"given":"Lingmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Multi-scale Porous Materials Center, Institute of Advanced Interdisciplinary Studies & School of Chemistry and Chemical Engineering","place":["Chongqing, China"]},{"name":"Chongqing University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1462-1118","authenticated-orcid":true,"given":"Yu","family":"Han","sequence":"additional","affiliation":[{"name":"Center for Electron Microscopy","place":["Guangzhou, China"]},{"name":"South China University of Technology","place":["Guangzhou, China"]},{"name":"School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices","place":["Guangzhou, China"]},{"name":"South China University of Technology","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-6036","authenticated-orcid":true,"given":"Gangfeng","family":"Ouyang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry","place":["Guangzhou, China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, China"]},{"name":"School of Chemical Engineering and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)","place":["Zhuhai, China"]},{"name":"Sun Yat-sen University","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07506-w"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1262-8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08399-5"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-025-02010-2"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00932-z"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1126\/science.221.4607.259"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2149-4"},{"key":"ref8\/cit8","unstructured":"Biocatalysts Market by Type (Hydrolases, Isomerases,\nLigases), Application\n(Agriculture & Feed, Biofuels, Food & Beverages), End-User,\nSource, Form - Global Forecast 2025-2030\n                      . Available at: https:\/\/www.giiresearch.com\/report\/ires1572966-biocatalysts-market-by-type-hydrolases-isomerases.html#:~:text=Biocatalysts%20Market%20by%20Type%20%28Hydrolases%2C%20Isomerases%2C%20Ligases%29%2C%20Application,of%207.48%25%2C%20to%20USD%20908.67%20million%20by%202030 (2024)."},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41567-022-01506-1"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/35053176"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1182669"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/s11084-007-9067-4"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2025054118"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao0335"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/35051706"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230444"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2738-2"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1126\/science.1220131"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8240"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28615-y"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2018.03.001"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/ja2038003"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c05488"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax5785"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-018-0117-2"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b04996"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c09647"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32454-2"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07870"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201811327"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c07482"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202417206"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.26599\/NR.2025.94908061"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c07600"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201909834"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03429-y"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04876-x"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn7667"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/ja4050828"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC04220A"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.22885"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam6203"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/bi201284u"},{"issue":"1","key":"ref44\/cit44","first-page":"353","volume":"255","author":"Schejter A.","year":"1988","journal-title":"Biochem. J."},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/ja00259a056"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/ja001137s"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1126\/science.3358128"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/cr9500500"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07023-1"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c04250"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c22730","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.5c22730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:49:08Z","timestamp":1775033348000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c22730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,4,1]]}},"alternative-id":["10.1021\/jacs.5c22730"],"URL":"https:\/\/doi.org\/10.1021\/jacs.5c22730","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]}}}