{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:15:26Z","timestamp":1788333326824,"version":"build-2803163510"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA-19033"],"award-info":[{"award-number":["CA-19033"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM-29028"],"award-info":[{"award-number":["GM-29028"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anion relay chemistry (ARC), an effective, multicomponent union tactic, was successfully employed for the total synthesis of the highly cytotoxic marine macrolide (\u2212)-mandelalide A (1). The northern hemisphere was constructed via a new type II ARC\/CuCN cross-coupling tactic, while the southern hemisphere was secured via a highly efficient four-component type I ARC union. Importantly, the synthesis of 1 showcases ARC as a rapid, scalable coupling strategy for the union of simple readily available building blocks to access diverse complex molecular fragments with excellent stereochemical control.<\/jats:p>","DOI":"10.1021\/jacs.6b01731","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T16:13:57Z","timestamp":1457453637000},"page":"3675-3678","source":"Crossref","is-referenced-by-count":77,"title":["Total\nSynthesis of (\u2212)-Mandelalide A Exploiting\nAnion Relay Chemistry (ARC): Identification of a Type II ARC\/CuCN\nCross-Coupling Protocol"],"prefix":"10.1021","volume":"138","author":[{"given":"Minh H.","family":"Nguyen","sequence":"first","affiliation":[{"name":"University of Pennsylvania , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Imanishi","sequence":"additional","affiliation":[{"name":"University of Pennsylvania , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Kurogi","sequence":"additional","affiliation":[{"name":"University of Pennsylvania , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Amos B.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Pennsylvania , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"2026090202461472200_cit1","doi-asserted-by":"publisher","first-page":"6066","DOI":"10.1021\/jo3008622","volume":"77","author":"Sikorska","year":"2012","journal-title":"J. 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