{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:43:30Z","timestamp":1792122210479,"version":"4.4.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"13","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["22210412"],"award-info":[{"award-number":["22210412"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ4007"],"award-info":[{"award-number":["2024JJ4007"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1800100"],"award-info":[{"award-number":["2023YFD1800100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011408","name":"State Key Laboratory of Medicinal Chemical Biology","doi-asserted-by":"publisher","award":["2025001"],"award-info":[{"award-number":["2025001"]}],"id":[{"id":"10.13039\/501100011408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014978","name":"Hunan University of Chinese Medicine","doi-asserted-by":"publisher","award":["2025XYLH272"],"award-info":[{"award-number":["2025XYLH272"]}],"id":[{"id":"10.13039\/501100014978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2024RC3078"],"award-info":[{"award-number":["2024RC3078"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177031"],"award-info":[{"award-number":["22177031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Changsha Municipal Natural Science Foundation","award":["kzd2401048"],"award-info":[{"award-number":["kzd2401048"]}]},{"name":"Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs","award":["2023TP1013"],"award-info":[{"award-number":["2023TP1013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2026,4,8]]},"DOI":"10.1021\/jacs.6c03697","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T19:44:00Z","timestamp":1774295040000},"page":"14662-14679","source":"Crossref","is-referenced-by-count":2,"title":["Coupled Hydrogen-Bond\u2013Electrostatic Recognition of Phosphatidylglycerol Drives the Design of Resistance-Suppressing Miniature Peptidomimetics"],"prefix":"10.1021","volume":"148","author":[{"given":"Xubo","family":"Tong","sequence":"first","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]},{"name":"State Key Laboratory of Medicinal Chemical Biology","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]},{"name":"Department of Dermatology","place":["Chongqing, China"]},{"name":"The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjia","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]},{"name":"State Key Laboratory of Medicinal Chemical Biology","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Mao","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiren","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqian","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwu","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyi","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihan","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs","place":["Changsha, China"]},{"name":"The Third Hospital of Changsha (The Affiliated Changsha Hospital of Hunan University)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Deng","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs","place":["Changsha, China"]},{"name":"The Third Hospital of Changsha (The Affiliated Changsha Hospital of Hunan University)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-7578","authenticated-orcid":true,"given":"Wing-Leung","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Mao","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs","place":["Changsha, China"]},{"name":"The Third Hospital of Changsha (The Affiliated Changsha Hospital of Hunan University)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs","place":["Changsha, China"]},{"name":"The Third Hospital of Changsha (The Affiliated Changsha Hospital of Hunan University)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Song","sequence":"additional","affiliation":[{"name":"Lab of Advanced Materials, College of Smart Materials and Future Energy, Department of Chemistry","place":["Shanghai, China"]},{"name":"Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-5629","authenticated-orcid":true,"given":"Xinxin","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering","place":["Changsha, China"]},{"name":"Hunan University","place":["Changsha, China"]},{"name":"Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs","place":["Changsha, China"]},{"name":"The Third Hospital of Changsha (The Affiliated Changsha Hospital of Hunan University)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-021-00343-2"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.100954"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2474"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c10200"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c06603"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.12.016"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bsheal.2022.02.003"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuv008"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.138"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2018.10.103"},{"key":"ref12\/cit12","first-page":"163","volume-title":"Progress in molecular biology and translational science","volume":"212","author":"Taylor S. D.","year":"2025"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscia.2023.100034"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026997"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.08.034"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.02.009"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2004.04.020"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2011.01.001"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/bi500779g"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.02.009"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00030-13"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01741-10"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-013-0062-9"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11091164"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2018.09.004"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1086\/430352"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2024.101307"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100749"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adn9435"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123392"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.02.036"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads2675"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.fluid.2008.01.024"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1039\/B614208G"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ja310834w"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S99046"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh546"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.554444"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01743-12"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.1c00316"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c03784"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/jm501449u"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.51"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00643-15"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.01.021"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118025"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-7348.1935.tb07713.x"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00616"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn0771"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01179"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c03697","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c03697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:44:35Z","timestamp":1775637875000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.6c03697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":50,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,4,8]]}},"alternative-id":["10.1021\/jacs.6c03697"],"URL":"https:\/\/doi.org\/10.1021\/jacs.6c03697","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]}}}