{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:55:05Z","timestamp":1793199305183,"version":"4.5.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"19","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100017427","name":"George E. Hewitt Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017427","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011195","name":"Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011195","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011769","name":"Scripps Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35 GM158311"],"award-info":[{"award-number":["R35 GM158311"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2026,5,20]]},"DOI":"10.1021\/jacs.6c03711","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:11:33Z","timestamp":1777918293000},"page":"20045-20053","source":"Crossref","is-referenced-by-count":3,"title":["Ligand-Enabled Pd-Catalyzed C(sp\n                    <sup>3<\/sup>\n                    )\u2013H\/C(sp\n                    <sup>2<\/sup>\n                    )\u2013H Coupling"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1488-5169","authenticated-orcid":true,"given":"Haiwei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Chemistry","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9532-0610","authenticated-orcid":true,"given":"Yu-Kun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3560-5774","authenticated-orcid":true,"given":"Jin-Quan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["La Jolla, United States"]},{"name":"The Scripps Research Institute","place":["La Jolla, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1039\/c2md20347b"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00093"},{"key":"ref3\/cit3","volume-title":"Friedel-Crafts Alkylation Chemistry, A Century of Discovery","author":"Roberts R. M.","year":"1984"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","unstructured":"Tamao, K. In\n                      Comprehensive Organic Synthesis\n                      ; Trost, B., Ed. Elsevier: Permagon, Oxford, 1991; Vol. 3, pp 435\u2013480.","DOI":"10.1016\/B978-0-08-052349-1.00069-X"},{"key":"ref5\/cit5a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201806629"},{"key":"ref5\/cit5b","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c05580"},{"key":"ref6\/cit6a","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15058h"},{"key":"ref6\/cit6b","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00519"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1039\/D3QO01925J"},{"key":"ref8\/cit8a","doi-asserted-by":"publisher","DOI":"10.2174\/1570179415666180720111422"},{"key":"ref8\/cit8b","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c01243"},{"key":"ref9\/cit9a","doi-asserted-by":"publisher","DOI":"10.1021\/ja051402f"},{"key":"ref9\/cit9b","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC02143J"},{"key":"ref9\/cit9c","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC04252C"},{"key":"ref9\/cit9d","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b02167"},{"key":"ref9\/cit9e","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b02265"},{"key":"ref9\/cit9f","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2019.05.008"},{"key":"ref9\/cit9g","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c00588"},{"key":"ref9\/cit9h","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC01944B"},{"key":"ref10\/cit10a","doi-asserted-by":"publisher","DOI":"10.1039\/D1GC01871J"},{"key":"ref10\/cit10b","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c01519"},{"key":"ref10\/cit10c","doi-asserted-by":"publisher","DOI":"10.1021\/ja300684r"},{"key":"ref10\/cit10d","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201201988"},{"key":"ref10\/cit10e","doi-asserted-by":"publisher","DOI":"10.1021\/ja501681y"},{"key":"ref10\/cit10f","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201300833"},{"key":"ref10\/cit10g","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA19000F"},{"key":"ref10\/cit10h","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b00923"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06000-z"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09205"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1126\/science.ado1246"},{"key":"ref14\/cit14a","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00328K"},{"key":"ref14\/cit14b","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2017.12.026"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202400509"},{"key":"ref16\/cit16a","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg2362"},{"key":"ref16\/cit16b","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08332"},{"key":"ref16\/cit16c","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01631"},{"key":"ref16\/cit16d","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c03858"},{"key":"ref16\/cit16e","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202420443"},{"key":"ref17\/cit17a","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl3939"},{"key":"ref17\/cit17b","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq3048"},{"key":"ref17\/cit17c","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202214459"},{"key":"ref17\/cit17d","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c09040"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c05774"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c04779"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","DOI":"10.1201\/b16932","volume-title":"Handbook of Grignard Reagents","author":"Silverman G. S.","year":"1996"},{"key":"ref21\/cit21a","doi-asserted-by":"crossref","unstructured":"ade Meijere, A.; Brase, S.; Oestreich, M.\n                      Metal Catalyzed Cross Coupling Reactions and More\n                      ; Wiley: Weinheim, 2013; Vol. 3, pp 1329\u20131348.","DOI":"10.1002\/9783527655588"},{"key":"ref21\/cit21b","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-939728"},{"key":"ref22\/cit22a","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5c00503"},{"key":"ref22\/cit22b","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c03623"},{"key":"ref23\/cit23a","doi-asserted-by":"publisher","DOI":"10.1021\/cr60095a004"},{"key":"ref23\/cit23b","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.349"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c03711","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c03711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:43:20Z","timestamp":1779266600000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.6c03711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":51,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,5,20]]}},"alternative-id":["10.1021\/jacs.6c03711"],"URL":"https:\/\/doi.org\/10.1021\/jacs.6c03711","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]}}}