{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:49:27Z","timestamp":1792788567211,"version":"4.5.0"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"23","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03111"],"award-info":[{"award-number":["2024C03111"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03123"],"award-info":[{"award-number":["2024C03123"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011245","name":"State Key Laboratory of Coordination Chemistry","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100011245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226-2025-00201"],"award-info":[{"award-number":["226-2025-00201"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22238008"],"award-info":[{"award-number":["22238008"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22478341"],"award-info":[{"award-number":["22478341"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22478344"],"award-info":[{"award-number":["22478344"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Baima Lake Laboratory Joint Fund of Zhejiang Provincial Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LBMHQN26E060004"],"award-info":[{"award-number":["LBMHQN26E060004"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sustainable biomanufacturing of high-value, structurally complex chemicals directly from CO2 represents a frontier for carbon neutrality yet remains fundamentally constrained by a trade-off intrinsic to photobiohybrid systems: catabolic oxidation of fixed carbon must be invoked to regenerate intracellular reducing power, creating a futile cycle that reoxidizes photosynthetically fixed carbon back to CO2 and erodes the overall carbon atom economy. Overcoming this bottleneck requires a unified platform capable of simultaneously supplying carbon substrates and regenerating reducing equivalents to maximize anabolic flux. Here, we report a spatiotemporally decoupled photobiohybrid system that achieves carbon-efficient CO2 conversion through an \u201cextracellular fixation and intracellular empowerment\u201d strategy. A bifunctional catalyst of iron single atoms anchored on nitrogen-doped carbon quantum dots (Fe-NC QDs), featuring atomically dispersed Fe\u2013N4 active sites, was developed. Extracellularly, the Fe-NC QDs catalyze CO2 reduction to methanol with a production rate of 826.10 \u03bcmol\u00b7g\u20131\u00b7h\u20131 and 91.33% selectivity; intracellularly, the same QDs are internalized by engineered Pichia pastoris and photocatalytically regenerate NADH through a flavin-mediated electron transport chain. Coupling this bifunctional catalyst with an artificial phosphoketolase pathway enables the direct conversion of CO2 into the C15 aviation fuel precursor epi-isozizaene at a titer of 1.98 mg\u00b7L\u20131, corresponding to a 3-fold increase in product titer over conventional methanol-feeding strategies. By spatiotemporally decoupling carbon supply from energy regeneration, this work establishes a generalizable framework for solar-driven biosynthesis of complex multicarbon feedstocks and advances the development of a circular bioeconomy.<\/jats:p>","DOI":"10.1021\/jacs.6c04185","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:47:37Z","timestamp":1780480057000},"page":"24029-24040","source":"Crossref","is-referenced-by-count":4,"title":["Spatiotemporal Decoupling\nof Carbon and Energy Flux\nEnables Efficient Biomanufacturing of Aviation Fuel Precursors from\nCO2"],"prefix":"10.1021","volume":"148","author":[{"given":"Yang","family":"Ye","sequence":"first","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1311-9209","authenticated-orcid":true,"given":"Feng","family":"Dong","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghai","family":"Bian","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazhi","family":"Bai","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-9743","authenticated-orcid":true,"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Institute of Zhejiang University\u2500Quzhou , ,","place":["Quzhou, China, 324000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9795-8503","authenticated-orcid":true,"given":"Yang","family":"Hou","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lecheng","family":"Lei","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Institute of Zhejiang University\u2500Quzhou , ,","place":["Quzhou, China, 324000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9784-9876","authenticated-orcid":true,"given":"Jiazhang","family":"Lian","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310000"]},{"name":"Nanjing University , , ,","place":["Nanjing, China, 210093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-381X","authenticated-orcid":true,"given":"Zhongjian","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Institute of Zhejiang University\u2500Quzhou , ,","place":["Quzhou, China, 324000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"2026073023063141800_cit1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41570-023-00567-x","article-title":"Solar Reforming as an Emerging Technology\nfor Circular Chemical Industries","volume":"8","author":"Bhattacharjee","year":"2024","journal-title":"Nat. Rev.\nChem."},{"key":"2026073023063141800_cit2","doi-asserted-by":"publisher","first-page":"102450","DOI":"10.1016\/j.chempr.2025.102450","article-title":"Photocatalytic\nProduct-Selective Reduction of CO2, CO, and Carbonates","volume":"11","author":"Bhimpuria","year":"2025","journal-title":"Chem"},{"key":"2026073023063141800_cit3","doi-asserted-by":"publisher","first-page":"103051","DOI":"10.1016\/j.jcou.2025.103051","article-title":"Light-Driven Eosin\nY-Ralstonia eutropha Biohybrid\nfor CO2 Conversion to Acetoin via Specific Photo-Induced\nElectron Transfer and Metabolic Engineering","volume":"93","author":"Tian","year":"2025","journal-title":"J. CO2 Util."},{"key":"2026073023063141800_cit4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202414981","article-title":"A Photosynthesis-Derived\nBionic System for Sustainable Biosynthesis","volume":"64","author":"Chen","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026073023063141800_cit5","doi-asserted-by":"publisher","first-page":"108319","DOI":"10.1016\/j.biotechadv.2024.108319","article-title":"Genome-Scale\nMetabolic Network Models for Industrial Microorganisms\nMetabolic Engineering: Current Advances and Future Prospects","volume":"72","author":"Gong","year":"2024","journal-title":"Biotechnol. Adv."},{"key":"2026073023063141800_cit6","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423995","article-title":"Coupling\nPhotocatalytic Reduction and Biosynthesis Towards Sustainable CO2 Upcycling","volume":"64","author":"Yu","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026073023063141800_cit7","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1126\/science.aat9777","article-title":"Light-Driven Fine Chemical Production in Yeast Biohybrids","volume":"362","author":"Guo","year":"2018","journal-title":"Science"},{"key":"2026073023063141800_cit8","doi-asserted-by":"publisher","first-page":"7017","DOI":"10.1039\/D4EE02262A","article-title":"Microbial\nConversion of CO2 to Organic Compounds","volume":"17","author":"Li","year":"2024","journal-title":"Energy Environ. Sci."},{"key":"2026073023063141800_cit9","doi-asserted-by":"publisher","first-page":"132949","DOI":"10.1016\/j.biortech.2025.132949","article-title":"Biohybrid Technologies\nfor CO2 Conversion to Fuels and Chemicals: Advances in\nBio-Electro-, Bio-Photoelectro-, and Bio-Photocatalysis","volume":"435","author":"Chen","year":"2025","journal-title":"Bioresour. Technol."},{"key":"2026073023063141800_cit10","doi-asserted-by":"publisher","DOI":"10.1111\/gcb.70045","article-title":"Multifaceted\nLinks Between Microbial Carbon Use Efficiency and Soil Organic Carbon\nSequestration","volume":"31","author":"Fang","year":"2025","journal-title":"Glob. Change Biol."},{"key":"2026073023063141800_cit11","doi-asserted-by":"publisher","first-page":"nwae059","DOI":"10.1093\/nsr\/nwae059","article-title":"Beyond Microbial Carbon Use Efficiency","volume":"11","author":"Xiao","year":"2024","journal-title":"Natl. Sci. Rev."},{"key":"2026073023063141800_cit12","doi-asserted-by":"publisher","first-page":"8012","DOI":"10.1038\/s41467-023-43524-4","article-title":"Engineering Artificial Photosynthesis\nBased on Rhodopsin for CO2 Fixation","volume":"14","author":"Tu","year":"2023","journal-title":"Nat. Commun."},{"key":"2026073023063141800_cit13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2404958121","article-title":"Engineering\nBionanoreactor in Bacteria\nfor Efficient Hydrogen Production","volume":"121","author":"Tu","year":"2024","journal-title":"Proc. Natl.\nAcad. Sci. U.S.A."},{"key":"2026073023063141800_cit14","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202412072","article-title":"Long-Term Autotrophic Growth and Solar-to-Chemical\nConversion in Shewanella oneidensis MR-1 through\nLight-Driven Electron Transfer","volume":"63","author":"Shi","year":"2024","journal-title":"Angew. Chem.,\nInt. Ed."},{"key":"2026073023063141800_cit15","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1126\/science.abh4049","article-title":"Cell-Free Chemoenzymatic\nStarch Synthesis from Carbon Dioxide","volume":"373","author":"Cai","year":"2021","journal-title":"Science"},{"key":"2026073023063141800_cit16","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202424537","article-title":"Revisiting Photocatalytic CO2 Reduction\nto Methanol: A Perspective Focusing on Metal-Organic Frameworks","volume":"64","author":"Fernandes de Almeida","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026073023063141800_cit17","doi-asserted-by":"publisher","first-page":"25097","DOI":"10.1021\/jacs.5c09410","article-title":"Binding-Enhanced Organic Semiconductor-Bacteria Hybrids for Efficient\nVisible Light-Driven CO2 Conversion to Bioplastics","volume":"147","author":"Zhang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026073023063141800_cit18","doi-asserted-by":"publisher","first-page":"132815","DOI":"10.1016\/j.biortech.2025.132815","article-title":"Methylotrophic Yeasts for Chemicals Production Using Methanol as\nSubstrate: Current Status, Challenges, and Strategies","volume":"434","author":"Duan","year":"2025","journal-title":"Bioresour. Technol."},{"key":"2026073023063141800_cit19","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s43586-023-00243-w","article-title":"Photocatalytic\nCO2 Reduction","volume":"3","author":"Fang","year":"2023","journal-title":"Nat. Rev. Methods\nPrimers"},{"key":"2026073023063141800_cit20","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1016\/j.joule.2022.08.002","article-title":"Living Intracellular\nInorganic-Microorganism Biohybrid System for Efficient Solar Hydrogen\nGeneration","volume":"6","author":"Wu","year":"2022","journal-title":"Joule"},{"key":"2026073023063141800_cit21","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1021\/jacsau.3c00557","article-title":"Single-Atom Catalysts for Selective Oxygen Reduction:\nTransition\nMetals in Uniform Carbon Nanospheres with High Loadings","volume":"3","author":"Jeskey","year":"2023","journal-title":"JACS Au"},{"key":"2026073023063141800_cit22","doi-asserted-by":"publisher","first-page":"821","DOI":"10.3390\/catal15090821","article-title":"1,10-Phenanthroline-Iron\nComplex-Derived Fe-N-C Electrocatalysts:\nEnhanced Oxygen Reduction Activity and Stability through Synthesis\nTuning","volume":"15","author":"Vasconcellos","year":"2025","journal-title":"Catalysts"},{"key":"2026073023063141800_cit23","doi-asserted-by":"publisher","first-page":"124881","DOI":"10.1016\/j.apcatb.2024.124881","article-title":"Visible-Light-Promoted Peroxymonosulfate Activation for ACE Degradation:\nOverlooked Role of Photogenerated Hole","volume":"365","author":"Jiang","year":"2025","journal-title":"Appl.\nCatal. B Environ."},{"key":"2026073023063141800_cit24","doi-asserted-by":"publisher","first-page":"9078","DOI":"10.1002\/anie.202100526","article-title":"Boosting Electroreduction\nKinetics of Nitrogen to Ammonia via Tuning\nElectron Distribution of Single-Atomic Iron Sites","volume":"60","author":"Li","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026073023063141800_cit25","doi-asserted-by":"publisher","first-page":"135","DOI":"10.11868\/j.issn.1001-4381.2023.000207","article-title":"Synthesis of ZIF-8 Derived High-Efficiency\nFe-N-C Catalyst and Its Oxygen Reduction Reaction Performance","volume":"53","author":"Zhang","year":"2025","journal-title":"J. Mater. Eng."},{"key":"2026073023063141800_cit26","doi-asserted-by":"publisher","first-page":"21871","DOI":"10.1021\/acs.est.4c08224","article-title":"Activation of PAA at\nthe Fe-Nx Sites by Boron Nitride Quantum Dots\nEnhanced Charge Transfer Generates High-Valent Metal-Oxo Species for\nAntibiotics Degradation","volume":"58","author":"Li","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"2026073023063141800_cit27","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/s41929-025-01324-7","article-title":"Identifying High-Spin Hydroxyl-Coordinated Fe3+N4 as the Active Centre for Acidic Oxygen Reduction Using\nMolecular\nModel Catalysts","volume":"8","author":"Zhao","year":"2025","journal-title":"Nat. Catal."},{"key":"2026073023063141800_cit28","doi-asserted-by":"publisher","first-page":"120695","DOI":"10.1016\/j.apcatb.2021.120695","article-title":"Ultrahigh Surface Density of Co-N2C Single-Atom-Sites\nfor Boosting Photocatalytic CO2 Reduction to Methanol","volume":"300","author":"Ma","year":"2022","journal-title":"Appl. Catal. B Environ."},{"key":"2026073023063141800_cit29","doi-asserted-by":"publisher","first-page":"154701","DOI":"10.1016\/j.cej.2024.154701","article-title":"Bimetallic NiCu Catalyst\nDerived from Spent MOF Adsorbent for Efficient\nPhotocatalytic CO2 Reduction","volume":"497","author":"Zhang","year":"2024","journal-title":"Chem.\nEng. J."},{"key":"2026073023063141800_cit30","doi-asserted-by":"publisher","first-page":"122626","DOI":"10.1016\/j.apcatb.2023.122626","article-title":"Modulating Photogenerated\nElectron Density of Pr Single-Atom Sites\nby Coordination Environment Engineering for Boosting Photoreduction\nof CO2 to CH3OH","volume":"330","author":"Ma","year":"2023","journal-title":"Appl.\nCatal. B Environ."},{"key":"2026073023063141800_cit31","doi-asserted-by":"publisher","first-page":"19339","DOI":"10.1021\/jacs.0c09599","article-title":"Photoinduction of Cu\nSingle Atoms Decorated on UiO-66-NH2 for Enhanced Photocatalytic\nReduction of CO2 to Liquid\nFuels","volume":"142","author":"Wang","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"2026073023063141800_cit32","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/s42255-022-00654-1","article-title":"Metabolic Reconfiguration Enables Synthetic Reductive Metabolism\nin Yeast","volume":"4","author":"Yu","year":"2022","journal-title":"Nat. Metab."},{"issue":"6","key":"2026073023063141800_cit33","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1007\/s00203-020-01835-w","article-title":"Yeast Engineered Translucent Cell Wall to Provide Its\nEndosymbiotic Cyanobacteria with Light","volume":"202","author":"Ebrahimi","year":"2020","journal-title":"Arch.\nMicrobiol."},{"key":"2026073023063141800_cit34","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1021\/acsenergylett.2c02707","article-title":"Ultrafast\nElectron Transfer in Au-Cyanobacteria Hybrid for Solar\nto Chemical Production","volume":"8","author":"Hu","year":"2023","journal-title":"ACS Energy Lett."},{"key":"2026073023063141800_cit35","doi-asserted-by":"publisher","first-page":"6710","DOI":"10.1021\/acscatal.4c00350","article-title":"Photoenzymatic Redox-Neutral\nRadical Hydrosulfonylation Initiated\nby FMN","volume":"14","author":"Jiang","year":"2024","journal-title":"ACS Catal."},{"key":"2026073023063141800_cit36","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1021\/cbe.4c00156","article-title":"Polythiophene-Based Nonmetal Electrocatalyst with Biocompatibility\nto Boost Efficient CO2 Conversion","volume":"2","author":"Bian","year":"2025","journal-title":"Chem. Bioeng."},{"key":"2026073023063141800_cit37","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1038\/s41560-023-01370-0","article-title":"An Active and Durable\nMolecular Catalyst for Aqueous Polysulfide-Based\nRedox Flow Batteries","volume":"8","author":"Lei","year":"2023","journal-title":"Nat. Energy"},{"key":"2026073023063141800_cit38","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1021\/bi047952s","article-title":"Redox Potential\nand Equilibria in the Reductive Half-Reaction of Vibrio harveyi NADPH-FMN Oxidoreductase","volume":"44","author":"Lei","year":"2005","journal-title":"Biochemistry"},{"key":"2026073023063141800_cit39","doi-asserted-by":"publisher","first-page":"116657","DOI":"10.1016\/j.jece.2025.116657","article-title":"In situ NADH Regeneration Coupled\nto Enzymatic CO2 Reduction: From Fundamental Concepts to\nRecent Advances","volume":"13","author":"Gupta","year":"2025","journal-title":"J. Environ. Chem. Eng."},{"key":"2026073023063141800_cit40","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.tcb.2025.07.005","article-title":"NADH Reductive Stress\nDrives Metabolic Reprogramming","volume":"36","author":"Yang","year":"2026","journal-title":"Trends Cell\nBiol."},{"key":"2026073023063141800_cit41","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1021\/acssynbio.1c00366","article-title":"Enhancing Homologous\nRecombination Efficiency in Pichia pastoris for Multiplex\nGenome Integration Using Short Homology Arms","volume":"11","author":"Gao","year":"2022","journal-title":"ACS Synth. Biol."},{"key":"2026073023063141800_cit42","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nature12575","article-title":"Synthetic\nNon-Oxidative Glycolysis\nEnables Complete Carbon Conservation","volume":"502","author":"Bogorad","year":"2013","journal-title":"Nature"},{"key":"2026073023063141800_cit43","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13068-021-01962-6","article-title":"Increasing\nLipid Yield in Yarrowia lipolytica through Phosphoketolase\nand Phosphotransacetylase\nExpression in a Phosphofructokinase Deletion Strain","volume":"14","author":"Kamineni","year":"2021","journal-title":"Biotechnol. Biofuels"},{"key":"2026073023063141800_cit44","doi-asserted-by":"publisher","first-page":"2400261","DOI":"10.1002\/biot.202400261","article-title":"Engineering\na Versatile Yeast Platform for Sesquiterpene Production from Glucose\nor Methanol","volume":"19","author":"Gao","year":"2024","journal-title":"Biotechnol. J."},{"key":"2026073023063141800_cit45","doi-asserted-by":"publisher","first-page":"6022","DOI":"10.1021\/ja061292s","article-title":"Genome Mining in Streptomyces coelicolor:\nMolecular Cloning and Characterization of a New Sesquiterpene Synthase","volume":"128","author":"Lin","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"2026073023063141800_cit46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2211827119","article-title":"Conversion\nof CO2 into Organic Acids by Engineered Autotrophic Yeast","volume":"119","author":"Baumschabl","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026073023063141800_cit47","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202514577","article-title":"Defects Induced\nin situ Reconstruction of CdS with Oxygen-Tolerance Up to 23% in the\nPhotocatalytic CO2 Reduction","volume":"64","author":"Liang","year":"2025","journal-title":"Angew.\nChem., Int. 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