{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:16:17Z","timestamp":1788455777827,"version":"build-2803163510"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"ANRF","doi-asserted-by":"publisher","award":["ANRF\/JBG\/000019CS"],"award-info":[{"award-number":["ANRF\/JBG\/000019CS"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/PR45525\/MED\/122\/311\/2022"],"award-info":[{"award-number":["BT\/PR45525\/MED\/122\/311\/2022"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The \u201cMagic Methyl Effect\u201d stands for the welcoming effect of the methyl group in enhancing the potency of drug precursors. To date, no catalytic chemical route for methylation of aryl halides that excludes organometallic species is known. In this report, we introduce an organometallic-free cross electrophile methylation of aryl halides based on the generation of a methyl anion achieved under chemical conditions. It successfully methylated several strong bonds, such as CAr\u2013Br, CAr\u2013Cl, and CAr\u2013F. This catalytic protocol was further diversified by preparing methyl derivatives of various clinically used antidepressants and antipsychotic drugs. Furthermore, we have demonstrated that the methylated product of one such drug molecule has significantly superior suppressive effects on neural activity as compared to the clinically active nonmethylated parent drug.<\/jats:p>","DOI":"10.1021\/jacs.6c05128","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T19:02:42Z","timestamp":1787079762000},"page":"36485-36498","source":"Crossref","is-referenced-by-count":0,"title":["Organometallic-Free\nCatalytic Cross-Electrophile Methylation\nof Aryl Halides"],"prefix":"10.1021","volume":"148","author":[{"given":"Swagata","family":"Sil","sequence":"first","affiliation":[{"name":"Indian Institute of Science Education and Research Kolkata , , ,","place":["Mohanpur, India, 741246"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena","family":"Mandal","sequence":"additional","affiliation":[{"name":"Case Western Reserve University , , ,","place":["Cleveland, Ohio, United States, 44106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balakumar","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"BRIC - National Brain Research Centre , ,","place":["Manesar, India, 122052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramita","family":"Datta","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research Kolkata , , ,","place":["Mohanpur, India, 741246"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha P.","family":"Dey","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research Kolkata , , ,","place":["Mohanpur, India, 741246"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallabi","family":"Mandal","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research Kolkata , , ,","place":["Mohanpur, India, 741246"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourav","family":"Banerjee","sequence":"additional","affiliation":[{"name":"BRIC - National Brain Research Centre , ,","place":["Manesar, India, 122052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3471-7053","authenticated-orcid":true,"given":"Swadhin K.","family":"Mandal","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research Kolkata , , ,","place":["Mohanpur, India, 741246"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"2026090312072608400_cit1","doi-asserted-by":"publisher","first-page":"555761","DOI":"10.19080\/GJPPS.2021.09.555761","article-title":"Magic Methyl Effects in Drug Design","volume":"9","author":"Shah","year":"2021","journal-title":"Glob. J. Pharmaceu. Sci."},{"key":"2026090312072608400_cit2","doi-asserted-by":"publisher","first-page":"12256","DOI":"10.1002\/anie.201303207","article-title":"Profound Methyl Effects\nin Drug Discovery and a Call\nfor New C-H Methylation Reactions","volume":"52","author":"Scho\u0308nherr","year":"2013","journal-title":"Angew. Chem.,\nInt. Ed."},{"key":"2026090312072608400_cit3","doi-asserted-by":"publisher","first-page":"5215","DOI":"10.1021\/cr200060g","article-title":"The Methylation Effect in Medicinal\nChemistry","volume":"111","author":"Barreiro","year":"2011","journal-title":"Chem. Rev."},{"key":"2026090312072608400_cit4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/jlcr.3253","article-title":"Pd-mediated\nrapid cross-couplings using [11C]methyl iodide: groundbreaking\nlabeling methods in 11C radiochemistry","volume":"58","author":"Doi","year":"2015","journal-title":"J. Label. Compd. Radiopharm."},{"key":"2026090312072608400_cit5","doi-asserted-by":"publisher","first-page":"6237","DOI":"10.1016\/S0040-4039(00)01038-8","article-title":"Practical methylation of aryl halides by Suzuki\u2013Miyaura coupling","volume":"41","author":"Gray","year":"2000","journal-title":"Tetrahedron Lett."},{"key":"2026090312072608400_cit6","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/s41557-020-0475-7","article-title":"Cobalt-catalysed\nC\u2013H methylation\nfor late-stage drug diversification","volume":"12","author":"Friis","year":"2020","journal-title":"Nat. Chem."},{"key":"2026090312072608400_cit7","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/s41586-020-2137-8","article-title":"Late-stage oxidative\nC(sp3)\u2013H methylation","volume":"580","author":"Feng","year":"2020","journal-title":"Nature"},{"key":"2026090312072608400_cit8","doi-asserted-by":"publisher","first-page":"5517","DOI":"10.1039\/D0CS00973C","article-title":"Installing\nthe \u201cmagic methyl\u201d \u2013 C\u2013H methylation in\nsynthesis","volume":"50","author":"Aynetdinova","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"2026090312072608400_cit9","doi-asserted-by":"publisher","first-page":"13397","DOI":"10.1021\/acs.chemrev.4c00524","article-title":"Cross-Electrophile\nCoupling: Principles, Methods, and\nApplications in Synthesis","volume":"124","author":"Ehehalt","year":"2024","journal-title":"Chem. Rev."},{"key":"2026090312072608400_cit10","doi-asserted-by":"publisher","first-page":"8084","DOI":"10.1021\/jacs.6b04818","article-title":"Silyl\nRadical Activation of Alkyl\nHalides in Metallaphotoredox Catalysis: A Unique Pathway for Cross-Electrophile\nCoupling","volume":"138","author":"Zhang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"2026090312072608400_cit11","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1021\/om900088z","article-title":"The Grignard\nReagents","volume":"28","author":"Seyferth","year":"2009","journal-title":"Organometallics"},{"key":"2026090312072608400_cit12","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/s41586-022-04540-4","article-title":"Electrochemically driven cross-electrophile coupling of alkyl halides","volume":"604","author":"Zhang","year":"2022","journal-title":"Nature"},{"key":"2026090312072608400_cit13","doi-asserted-by":"publisher","first-page":"8576","DOI":"10.1021\/ja00138a012","article-title":"Methyl\/Phenyl Exchange\nbetween Palladium\nand a Phosphine Ligand. Consequences for Catalytic Coupling Reactions","volume":"117","author":"Morita","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"2026090312072608400_cit14","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1002\/adsc.200505405","article-title":"User-Friendly\nMethylation of Aryl and Vinyl Halides and Pseudohalides with DABAL-Me3","volume":"348","author":"Cooper","year":"2006","journal-title":"Adv. Synth. Catal."},{"key":"2026090312072608400_cit15","doi-asserted-by":"publisher","first-page":"17197","DOI":"10.1021\/jacs.8b10076","article-title":"Trimethylphosphate\nas a Methylating Agent for Cross Coupling: A Slow-Release Mechanism\nfor the Methylation of Arylboronic Esters","volume":"140","author":"He","year":"2018","journal-title":"J.\nAm. Chem. Soc."},{"key":"2026090312072608400_cit16","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1021\/acs.orglett.9b00025","article-title":"Palladium-Catalyzed\nMethylation of Aryl, Heteroaryl,\nand Vinyl Boronate Esters","volume":"21","author":"Haydl","year":"2019","journal-title":"Org. Lett."},{"key":"2026090312072608400_cit17","doi-asserted-by":"publisher","first-page":"10180","DOI":"10.1039\/c7cc06106d","article-title":"Nickel-catalyzed\nmethylation of aryl\nhalides\/tosylates with methyl tosylate","volume":"53","author":"Wang","year":"2017","journal-title":"Chem.\nCommun."},{"key":"2026090312072608400_cit18","doi-asserted-by":"publisher","first-page":"11541","DOI":"10.1021\/acscatal.3c02761","article-title":"Robust\nand General Late-Stage Methylation of Aryl Chlorides: Application\nto Isotopic Labeling of Drug-like Scaffolds","volume":"13","author":"Davenport","year":"2023","journal-title":"ACS Catal."},{"key":"2026090312072608400_cit19","doi-asserted-by":"publisher","first-page":"9743","DOI":"10.1002\/anie.201604406","article-title":"Nickel-Catalyzed Methylation of Aryl Halides with Deuterated\nMethyl Iodide","volume":"55","author":"Hu","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"issue":"15","key":"2026090312072608400_cit20","doi-asserted-by":"publisher","first-page":"3575","DOI":"10.1016\/S0040-4020(01)97768-3","article-title":"Nucleophilic\ncharacter of alkyl radicals\u2500VI","volume":"27","author":"Minisci","year":"1971","journal-title":"Tetrahedron"},{"key":"2026090312072608400_cit21","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/s41586-021-03637-6","article-title":"A radical\napproach for the selective C\u2013H borylation\nof azines","volume":"595","author":"Kim","year":"2021","journal-title":"Nature"},{"key":"2026090312072608400_cit22","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.1039\/D0SC00712A","article-title":"Recent advances in\nphotoredox and\nnickel dual catalyzed cascade reactions: pushing the boundaries of\ncomplexity","volume":"11","author":"Zhu","year":"2020","journal-title":"Chem. Sci."},{"key":"2026090312072608400_cit23","doi-asserted-by":"publisher","first-page":"9055","DOI":"10.1021\/acscatal.4c02036","article-title":"Mechanisms of Photoredox\nCatalysis Featuring Nickel\u2013Bipyridine Complexes","volume":"14","author":"Cagan","year":"2024","journal-title":"ACS Catal."},{"key":"2026090312072608400_cit24","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41467-023-36103-0","article-title":"Modulating\nstereoselectivity in allylic\nC(sp3)-H bond arylations via nickel and photoredox catalysis","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"2026090312072608400_cit25","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/s41586-020-3015-0","article-title":"Metallaphotoredox aryl and alkyl\nradiomethylation for PET ligand discovery","volume":"589","author":"Pipal","year":"2021","journal-title":"Nature"},{"key":"2026090312072608400_cit26","doi-asserted-by":"publisher","first-page":"7683","DOI":"10.1021\/jacs.0c02805","article-title":"Nickel\/Photoredox-Catalyzed\nMethylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate\nas a Methyl Radical Source","volume":"142","author":"Kariofillis","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"2026090312072608400_cit27","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1021\/jacs.1c12203","article-title":"Using Data Science\nTo Guide Aryl Bromide Substrate\nScope Analysis in a Ni\/Photoredox-Catalyzed Cross-Coupling with Acetals\nas Alcohol-Derived Radical Sources","volume":"144","author":"Kariofillis","year":"2022","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026090312072608400_cit28","doi-asserted-by":"publisher","first-page":"11369","DOI":"10.1021\/acs.chemrev.1c00963","article-title":"Phenalenyl Radical:\nSmallest Polycyclic Odd Alternant\nHydrocarbon Present in the Graphene Sheet","volume":"122","author":"Ahmed","year":"2022","journal-title":"Chem.\nRev."},{"key":"2026090312072608400_cit29","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1126\/science.1112446","article-title":"Resonating Valence-Bond\nGround State in a Phenalenyl-Based\nNeutral Radical Conductor","volume":"309","author":"Pal","year":"2005","journal-title":"Science"},{"key":"2026090312072608400_cit30","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1021\/acs.accounts.7b00141","article-title":"Exploring Closed-Shell\nCationic Phenalenyl:\nFrom Catalysis to Spin Electronics","volume":"50","author":"Mukherjee","year":"2017","journal-title":"Acc. Chem.\nRes."},{"key":"2026090312072608400_cit31","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1126\/science.1071372","article-title":"Magneto-Opto-Electronic Bistability\nin a Phenalenyl-Based Neutral Radical","volume":"296","author":"Itkis","year":"2002","journal-title":"Science"},{"key":"2026090312072608400_cit32","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nchem.985","article-title":"Synthetic organic spin\nchemistry for structurally well-defined open-shell graphene fragments","volume":"3","author":"Morita","year":"2011","journal-title":"Nat. Chem."},{"key":"2026090312072608400_cit33","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/nmat3142","article-title":"Organic tailored batteries materials using stable open-shell molecules\nwith degenerate frontier orbitals","volume":"10","author":"Morita","year":"2011","journal-title":"Nat. Mater."},{"key":"2026090312072608400_cit34","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nature11719","article-title":"Interface-engineered\ntemplates for molecular spin memory devices","volume":"493","author":"Raman","year":"2013","journal-title":"Nature"},{"key":"2026090312072608400_cit35","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/256394a0","article-title":"Design\nof organic metals and superconductors","volume":"256","author":"Haddon","year":"1975","journal-title":"Nature"},{"key":"2026090312072608400_cit36","doi-asserted-by":"publisher","first-page":"15760","DOI":"10.1021\/jacs.7b07375","article-title":"B\u2013N\u2013B\nBond Embedded Phenalenyl and Its Anions","volume":"139","author":"Wei","year":"2017","journal-title":"J.\nAm. Chem. Soc."},{"key":"2026090312072608400_cit37","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1039\/D0SC05972B","article-title":"Switching\nbetween mono and doubly reduced odd alternant hydrocarbon: designing\na redox catalyst","volume":"12","author":"Ahmed","year":"2021","journal-title":"Chem. Sci."},{"key":"2026090312072608400_cit38","doi-asserted-by":"publisher","first-page":"5000","DOI":"10.1021\/acscatal.2c00173","article-title":"Tuning Redox States of Phenalenyl-Based Molecules by\nConsecutive Reduction toward Transition Metal-Free Heck-Type C\u2013C\nCross-Coupling","volume":"12","author":"Banik","year":"2022","journal-title":"ACS Catal."},{"key":"2026090312072608400_cit39","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202400895","article-title":"Cross-Coupling\nBetween Aryl Halides and Aryl Alkynes Catalyzed by an Odd Alternant\nHydrocarbon","volume":"30","author":"Sil","year":"2024","journal-title":"Chem. \u2212Eur. J"},{"key":"2026090312072608400_cit40","doi-asserted-by":"publisher","first-page":"22611","DOI":"10.1021\/jacs.2c09225","article-title":"Reduced-Phenalenyl-Based Molecule as a Super Electron\nDonor for Radical-Mediated C\u2013N Coupling Catalysis at Room Temperature","volume":"144","author":"Sil","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"2026090312072608400_cit41","doi-asserted-by":"publisher","first-page":"16737","DOI":"10.1021\/ja103050x","article-title":"Organocatalysis in\nCross-Coupling: DMEDA-Catalyzed Direct C-H Arylation of Unactivated\nBenzene","volume":"132","author":"Liu","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"2026090312072608400_cit42","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1038\/nchem.862","article-title":"An efficient\norganocatalytic method for constructing biaryls through aromatic C\u2013H\nactivation","volume":"2","author":"Sun","year":"2010","journal-title":"Nat. Chem."},{"key":"2026090312072608400_cit43","doi-asserted-by":"publisher","first-page":"4673","DOI":"10.1021\/ol8019764","article-title":"Potassium t-Butoxide\nAlone Can Promote the Biaryl Coupling of Electron-Deficient Nitrogen\nHeterocycles and Haloarenes","volume":"10","author":"Yanagisawa","year":"2008","journal-title":"Org. Lett."},{"key":"2026090312072608400_cit44","doi-asserted-by":"publisher","first-page":"11510","DOI":"10.1021\/jacs.8b07632","article-title":"Dual Roles for Potassium\nHydride in Haloarene Reduction:\nCSNAr and Single Electron Transfer Reduction via Organic\nElectron Donors Formed in Benzene","volume":"140","author":"Barham","year":"2018","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026090312072608400_cit45","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1039\/D3OB01743E","article-title":"An assay for aryl radicals using BHAS coupling","volume":"22","author":"Clark","year":"2024","journal-title":"Org. Biomol. Chem."},{"key":"2026090312072608400_cit46","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1055\/s-0039-1690614","article-title":"Ground State Cross-Coupling of Haloarenes with Arenes\nInitiated by Organic Electron Donors, Formed in situ: An Overview","volume":"52","author":"Nocera","year":"2020","journal-title":"Synthesis"},{"key":"2026090312072608400_cit47","doi-asserted-by":"publisher","first-page":"15537","DOI":"10.1021\/ja1080822","article-title":"tert-Butoxide-Mediated\nArylation of Benzene with Aryl Halides in the Presence of a Catalytic\n1,10-Phenanthroline Derivative","volume":"132","author":"Shirakawa","year":"2010","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026090312072608400_cit48","doi-asserted-by":"publisher","first-page":"6073","DOI":"10.1039\/C3CC48969H","article-title":"Evolution of neutral\norganic super-electron-donors\nand their applications","volume":"50","author":"Doni","year":"2014","journal-title":"Chem. Commun."},{"key":"2026090312072608400_cit49","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1039\/C3SC52315B","article-title":"Organic super-electron\ndonors: initiators in transition metal-free haloarene\u2013arene\ncoupling","volume":"5","author":"Zhou","year":"2014","journal-title":"Chem. Sci."},{"key":"2026090312072608400_cit50","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1126\/science.1258232","article-title":"Reduction\nof aryl halides by consecutive visible light-induced electron transfer\nprocesses","volume":"346","author":"Ghosh","year":"2014","journal-title":"Science"},{"key":"2026090312072608400_cit51","doi-asserted-by":"publisher","first-page":"14352","DOI":"10.1021\/jacs.1c06844","article-title":"How Radical\nAre \u201cRadical\u201d Photocatalysts? A Closed-Shell Meisenheimer\nComplex Is Identified as a Super-Reducing Photoreagent","volume":"143","author":"Rieth","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"2026090312072608400_cit52","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/s41586-020-2131-1","article-title":"Discovery and characterization\nof an acridine radical photoreductant","volume":"580","author":"MacKenzie","year":"2020","journal-title":"Nature"},{"key":"2026090312072608400_cit53","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202416472","article-title":"A BOIMPY\nDye Enables Multi-Photoinduced Electron Transfer Catalysis: Reaching\nSuper-Reducing Properties","volume":"64","author":"Biswas","year":"2025","journal-title":"Angew. Chem., Int.\nEd."},{"key":"2026090312072608400_cit54","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s41586-024-08327-7","article-title":"Photocatalytic\nC\u2013F bond activation in small molecules and polyfluoroalkyl\nsubstances","volume":"637","author":"Liu","year":"2025","journal-title":"Nature"},{"key":"2026090312072608400_cit55","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1021\/jacs.9b12328","article-title":"Potent\nReductants via Electron-Primed Photoredox Catalysis: Unlocking Aryl\nChlorides for Radical Coupling","volume":"142","author":"Cowper","year":"2020","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026090312072608400_cit56","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1021\/jacs.9b10678","article-title":"Reductive Electrophotocatalysis:\nMerging Electricity and Light To Achieve Extreme Reduction Potentials","volume":"142","author":"Kim","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"2026090312072608400_cit57","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1021\/ol800134g","article-title":"Super-Electron Donors: Bis-pyridinylidene\nFormation by Base Treatment of Pyridinium Salts","volume":"10","author":"Murphy","year":"2008","journal-title":"Org. Lett."},{"key":"2026090312072608400_cit58","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1007\/s11164-019-03817-0","article-title":"Electrocatalytic\ndeiodination of\nmethyl iodide on a copper electrode","volume":"45","author":"Huang","year":"2019","journal-title":"Res. Chem.\nIntermed."},{"key":"2026090312072608400_cit59","doi-asserted-by":"publisher","first-page":"8970","DOI":"10.1021\/jacs.5c22122","article-title":"How Alkali Metal Alkoxides Initiate\nOrganic Radical Reactions","volume":"148","author":"Tyerman","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026090312072608400_cit60","doi-asserted-by":"publisher","first-page":"46187","DOI":"10.1021\/jacs.5c14616","article-title":"Valorization of\nCO2 and N2O Gas Enabled by a Single Multi-Photoinduced\nElectron Transfer Catalyst","volume":"147","author":"Biswas","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026090312072608400_cit61","doi-asserted-by":"publisher","first-page":"7798","DOI":"10.1039\/C7SC02661G","article-title":"A new face of phenalenyl-based\nradicals in the transition\nmetal-free C\u2013H arylation of heteroarenes at room temperature:\ntrapping the radical initiator via C\u2013C \u03c3-bond formation","volume":"8","author":"Ahmed","year":"2017","journal-title":"Chem. Sci."},{"key":"2026090312072608400_cit62","doi-asserted-by":"publisher","first-page":"8330","DOI":"10.1021\/jacs.8b04786","article-title":"Integrating Organic\nLewis Acid and Redox Catalysis:\nThe Phenalenyl Cation in Dual Role","volume":"140","author":"Ahmed","year":"2018","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026090312072608400_cit63","first-page":"657","article-title":"Amoxapine:\nA clinical evaluation in depressive syndromes","volume":"14","author":"Charalampous","year":"1972","journal-title":"Curr. Ther Res. Clin Exp."},{"key":"2026090312072608400_cit64","first-page":"107","article-title":"The neuropharmacological actions\nof amoxapine","volume":"233","author":"Greenblatt","year":"1978","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"2026090312072608400_cit65","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/s41380-023-02397-1","article-title":"Targeting metaplasticity\nmechanisms to promote sustained\nantidepressant actions","volume":"29","author":"Brown","year":"2024","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"2026090312072608400_cit66","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/S2215-0366(24)00006-3","article-title":"Pharmacological treatments for psychotic depression:\nA systematic review and network meta-analysis","volume":"11","author":"Oliva","year":"2024","journal-title":"Lancet Psychiatry"},{"key":"2026090312072608400_cit67","doi-asserted-by":"publisher","first-page":"17118","DOI":"10.1002\/anie.201904795","article-title":"The Buchwald\u2013Hartwig\nAmination\nAfter 25 Years","volume":"58","author":"Dorel","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026090312072608400_cit68","doi-asserted-by":"publisher","first-page":"5084","DOI":"10.1039\/c1cs15071e","article-title":"Recent advances in\nSonogashira reactions","volume":"40","author":"Chinchilla","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"2026090312072608400_cit69","doi-asserted-by":"publisher","first-page":"15027","DOI":"10.1021\/jacs.0c06139","article-title":"Development of an\nAryl Amination Catalyst with Broad Scope Guided by Consideration of\nCatalyst Stability","volume":"142","author":"McCann","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"2026090312072608400_cit70","doi-asserted-by":"publisher","first-page":"4814","DOI":"10.1038\/s41467-018-07081-5","article-title":"Mechanism\nof copper-free Sonogashira reaction operates through palladium-palladium\ntransmetallation","volume":"9","author":"Gazvoda","year":"2018","journal-title":"Nat. Commun."},{"key":"2026090312072608400_cit71","doi-asserted-by":"publisher","first-page":"11615","DOI":"10.1039\/D3CC03855F","article-title":"Photochemical Sonogashira coupling\nreactions: beyond\ntraditional palladium\u2013copper catalysis","volume":"59","author":"Singh","year":"2023","journal-title":"Chem. Commun."},{"key":"2026090312072608400_cit72","doi-asserted-by":"publisher","first-page":"15830","DOI":"10.1021\/jacs.0c05901","article-title":"Mechanistic\nAnalysis of Metallaphotoredox C-N Coupling: Photocatalysis Initiates\nand Perpetuates Ni(I)\/Ni(III) Coupling Activity","volume":"142","author":"Till","year":"2020","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c05128","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/34\/36485\/66854352\/jacs.6c05128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/34\/36485\/66854352\/jacs.6c05128.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:24:24Z","timestamp":1788452664000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/34\/36485\/5275744\/Organometallic-Free-Catalytic-Cross-Electrophile"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":72,"journal-issue":{"issue":"34","published-online":{"date-parts":[[2026,8,18]]},"published-print":{"date-parts":[[2026,9,2]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c05128","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]}}}