{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:07:49Z","timestamp":1793275669027,"version":"4.5.0"},"reference-count":73,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","award":["R35 GM127071"],"award-info":[{"award-number":["R35 GM127071"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation (NSF)","doi-asserted-by":"crossref","award":["CHE-2247923"],"award-info":[{"award-number":["CHE-2247923"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this article, we report a regio- and enantioselective Rh-catalyzed hydroacylation of 2-azetines, enabled by strategic ligand control. The choice of the bisphosphine ligand dictates whether the reaction yields chiral 2-acylazetidines or achiral 3-acylazetidines. Electron-rich Josiphos ligands promote selective formation of 2-acylazetidines with high enantioselectivity, while biaryl bisphosphines such as dppe favor the formation of the 3-acylazetidine isomer. This study pioneers the use of enecarbamates as viable coupling partners in hydroacylation, expanding the scope of strained heterocyclic functionalization. Mechanistic analysis using distortion\u2013interaction models reveals that regiodivergence arises from distinct transition-state stabilization modes: dppe ligands allow regioselectivity to follow substrate electronics, while bulkier Josiphos ligands enforce steric and non-covalent interactions that override inherent reactivity.<\/jats:p>","DOI":"10.1021\/jacs.6c05233","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:13:18Z","timestamp":1785849198000},"page":"33129-33136","source":"Crossref","is-referenced-by-count":1,"title":["Regiodivergent Rhodium\nCatalysis: Enantioselective\nHydroacylation of 2-Azetines"],"prefix":"10.1021","volume":"148","author":[{"given":"Erin L.","family":"Kuker","sequence":"first","affiliation":[{"name":"University of California , , , ,","place":["Irvine, California, United States, 92687-2025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3179-7457","authenticated-orcid":true,"given":"Camryn E.","family":"Wallace","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Irvine, California, United States, 92687-2025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9029-3895","authenticated-orcid":true,"given":"Stephanie A.","family":"Corio","sequence":"additional","affiliation":[{"name":"Binghamton University , , , ,","place":["Binghamton, New York, United States, 13902-6000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice E.","family":"de Vos","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Irvine, California, United States, 92687-2025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-0561","authenticated-orcid":true,"given":"Jennifer S.","family":"Hirschi","sequence":"additional","affiliation":[{"name":"Binghamton University , , , ,","place":["Binghamton, New York, United States, 13902-6000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8099-1048","authenticated-orcid":true,"given":"Vy M.","family":"Dong","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Irvine, California, United States, 92687-2025"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"4","key":"2026081210074238900_cit1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010190","article-title":"Nicotianamine, a Novel Enhancer of\nRice Iron Bioavailability to Humans","volume":"5","author":"Zheng","year":"2010","journal-title":"PLoS One"},{"issue":"6","key":"2026081210074238900_cit2","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1105\/tpc.010256","article-title":"Role of\nNicotianamine in the Intracellular Delivery of Metals and Plant Reproductive\nDevelopment","volume":"15","author":"Takahashi","year":"2003","journal-title":"Plant Cell"},{"issue":"18","key":"2026081210074238900_cit3","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1056\/NEJMoa030104","article-title":"Secondary\nPrevention of Venous Thromboembolism with the Oral Direct Thrombin\nInhibitor Ximelagatran","volume":"349","author":"Schulman","year":"2003","journal-title":"N. 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