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This conclusion bears implications because the original assignment had been solely based on computational data, which had resulted in a remarkably high score of 99.93% that was ultimately misleading. The multiconvergent blueprint underlying the successful approach accounts for the fact that alongest linear sequence of 32 steps sufficed to reach this intricate marine natural product. The inherent flexibility should also empower future studies aiming at a detailed mapping of the pharmacophore of this compound endowed with significant antiplasmodial activity.<\/jats:p>","DOI":"10.1021\/jacs.6c05583","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:37:24Z","timestamp":1784205444000},"page":"30731-30743","source":"Crossref","is-referenced-by-count":1,"title":["Total Synthesis of\nBenthol A: The Nominal and the\nActual Natural Product"],"prefix":"10.1021","volume":"148","author":[{"given":"Guanghao","family":"Huang","sequence":"first","affiliation":[{"name":"Max-Planck-Institut fu\u0308r Kohlenforschung , ,","place":["Mu\u0308lheim\/Ruhr, Germany, 45470"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tomio","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fu\u0308r Kohlenforschung , ,","place":["Mu\u0308lheim\/Ruhr, Germany, 45470"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Varlet","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fu\u0308r Kohlenforschung , ,","place":["Mu\u0308lheim\/Ruhr, Germany, 45470"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conny","family":"Wirtz","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fu\u0308r Kohlenforschung , ,","place":["Mu\u0308lheim\/Ruhr, Germany, 45470"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0098-3417","authenticated-orcid":true,"given":"Alois","family":"Fu\u0308rstner","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fu\u0308r Kohlenforschung , ,","place":["Mu\u0308lheim\/Ruhr, Germany, 45470"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"23","key":"2026073021260506700_cit1","doi-asserted-by":"publisher","first-page":"13099","DOI":"10.1021\/acs.chemrev.4c00177","article-title":"The Chemistry\nof Phytoplankton","volume":"124","author":"Liu","year":"2024","journal-title":"Chem. 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