{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:31:22Z","timestamp":1793061082485,"version":"4.5.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council (ARC)","doi-asserted-by":"crossref","award":["FL250100011"],"award-info":[{"award-number":["FL250100011"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council (ARC)","doi-asserted-by":"crossref","award":["LP220100091"],"award-info":[{"award-number":["LP220100091"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2026,6,24]]},"DOI":"10.1021\/jacs.6c05882","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T19:27:07Z","timestamp":1781206027000},"page":"25050-25061","source":"Crossref","is-referenced-by-count":2,"title":["Towards Sustainable Synthesis of Peptide Therapeutics via Tag-Assisted Peptide Synthesis and Aryl Selenoester Aminolysis Ligation"],"prefix":"10.1021","volume":"148","author":[{"given":"Peter H. G.","family":"Egelund","sequence":"first","affiliation":[{"name":"School of Chemistry","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Rachid","sequence":"additional","affiliation":[{"name":"School of Chemistry","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Ayoub","sequence":"additional","affiliation":[{"name":"School of Chemistry","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra P.","family":"Platt","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Fort Collins, United States"]},{"name":"Colorado State University","place":["Fort Collins, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur H.","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Chemistry","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3926-7047","authenticated-orcid":true,"given":"Daniel","family":"Sejer Pedersen","sequence":"additional","affiliation":[{"name":"CMC API Development, Chemical Development, Novo Nordisk A\/S, Sm\u00f8rmosevej 17-19, Bagsv\u00e6rd 2880, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-4166","authenticated-orcid":true,"given":"Robert S.","family":"Paton","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Fort Collins, United States"]},{"name":"Colorado State University","place":["Fort Collins, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5896-9568","authenticated-orcid":true,"given":"Sameer S.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"School of Chemistry","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-9857","authenticated-orcid":true,"given":"Bhavesh","family":"Premdjee","sequence":"additional","affiliation":[{"name":"Department of Peptide Research","place":["M\u00e5l\u00f8v, Denmark"]},{"name":"Novo Nordisk A\/S","place":["M\u00e5l\u00f8v, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3618-9226","authenticated-orcid":true,"given":"Richard J.","family":"Payne","sequence":"additional","affiliation":[{"name":"School of Chemistry","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science","place":["Sydney, Australia"]},{"name":"The University of Sydney","place":["Sydney, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.06.052"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02107-5"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00904-4"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00318"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA07204D"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b03001"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/ja00897a025"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.09.23"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00135-8"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1039\/B700141J"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2476"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-018-0122"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/psc.70013"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.3c01494"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1126\/science.7973629"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503991"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ol006054v"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221012110"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b07237"},{"key":"ref20\/cit20","first-page":"193","author":"Malins L. R.","year":"2021","journal-title":"Science of Synthesis"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.9b00397"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202100185"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2012.02.006"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/ol302002g"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00132"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201702931"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.74.733"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc03090b"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.201700401"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.scp.2024.101684"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.6b02258"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jo302127d"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1186\/s40508-016-0051-z"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00050008"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201105512"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.5c00793"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202519647"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2017.04.003"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201703059"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b07877"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b02665"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201709418"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b03538"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-019-0180-4"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b12558"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c02280"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202200163"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200705298"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202104229"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(91)80869-8"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b03355"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/cr100048w"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2020.10.002"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00388"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC04742F"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.1c00108"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c05882","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c05882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:12:45Z","timestamp":1782288765000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.6c05882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":56,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2026,6,24]]}},"alternative-id":["10.1021\/jacs.6c05882"],"URL":"https:\/\/doi.org\/10.1021\/jacs.6c05882","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]}}}