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While significant efforts have been directed toward controlling Z\/E-selectivity, existing methods are largely incapable of achieving enantio- and Z\/E-stereodivergent synthesis, in which all four stereoisomers [(Z,R); (Z,S); (E,R); (E,S)] were selectively obtained, respectively. Herein, we report a Ni\/Pd synergistic catalysis for enantio- and Z\/E-stereodivergent synthesis of trisubstituted alkenes featuring \u03b1-chiral carbonyls. A Z\/E-mixture of readily available allylic carbonates were converted into either Z- or E-products in excellent yields with high enantio- and Z\/E-selectivities via a Z\/E-convergent asymmetric allylic substitution using 2-acylimidazole as nucleophile. DFT calculations revealed that a catalytic cavity, cooperatively formed by the Ni and Pd catalysts, precisely discerns the relative orientation (syn or anti) of the substituents on the \u03c0-allyl-Pd species within the competing transition states leading to Z- or E-products, thereby accounting for the high Z\/E-selectivity. This method establishes a general platform for the enantio- and Z\/E-stereodivergent synthesis of \u03b1-chiral ketones, carboxylic acids, amides, and esters featuring Z- or E-trisubstituted C\u2550C bonds.<\/jats:p>","DOI":"10.1021\/jacs.6c06266","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:58:16Z","timestamp":1780390696000},"page":"24405-24417","source":"Crossref","is-referenced-by-count":2,"title":["Enantio- and\n                    <i>Z<\/i>\n                    \/\n                    <i>E<\/i>\n                    -Stereodivergent Ni\/Pd Dual Catalysis\nfor Trisubstituted Alkenes\nFeaturing \u03b1-Chiral Carbonyls"],"prefix":"10.1021","volume":"148","author":[{"given":"Guanlin","family":"Li","sequence":"first","affiliation":[{"name":"Shanghai Jiao Tong University , , 800 Dongchuan Road , ,","place":["Shanghai, China, 200240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyun","family":"Lai","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , 800 Dongchuan Road , ,","place":["Shanghai, China, 200240"]},{"name":"Southern Medical University , , ,","place":["Shanghai, China, 201499"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , 800 Dongchuan Road , ,","place":["Shanghai, China, 200240"]},{"name":"Southern Medical University , , ,","place":["Shanghai, China, 201499"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , 800 Dongchuan Road , ,","place":["Shanghai, China, 200240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , 800 Dongchuan Road , ,","place":["Shanghai, China, 200240"]},{"name":"Zhengzhou Industrial Technology Research Institute of Shanghai Jiao Tong University , , ,","place":["Zhengzhou, Henan, China, 450000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Yu","family":"Han","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , 800 Dongchuan Road , ,","place":["Shanghai, China, 200240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ding","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , 800 Dongchuan Road , ,","place":["Shanghai, China, 200240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-099X","authenticated-orcid":true,"given":"Xiaohong","family":"Huo","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , 800 Dongchuan Road , ,","place":["Shanghai, China, 200240"]},{"name":"Zhengzhou Industrial Technology Research Institute of Shanghai Jiao Tong University , , ,","place":["Zhengzhou, Henan, China, 450000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Liang","family":"Sun","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Shanghai, China, 201499"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-4195","authenticated-orcid":true,"given":"Wanbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , 800 Dongchuan Road , ,","place":["Shanghai, China, 200240"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"2026073023171601400_cit1a","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/s41570-019-0117-z","article-title":"Stereochemical enhancement of polymer properties","volume":"3","author":"Worch","year":"2019","journal-title":"Nat. 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