{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:23:38Z","timestamp":1786548218814,"version":"build-2736575974"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"SYNBIO3 platform (IBMM, UMR CNRS 5247, University of Montpellier)"},{"name":"GIS IBiSA and I-SITE Excellence Program of the University of Montpellier (Investissements France 2030)"},{"name":"PAC Chimie Balard (UAR CNRS 2041)"},{"name":"UCA PARTNER"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peptoids, or N-substituted glycine oligomers, are a unique class of biomimetic foldamers. Peptoid oligomers are indeed capable of adopting well-defined ordered structures despite their intrinsic flexibility, which is primarily attributable to the cis\/trans isomerism of the main chain tertiary amide bonds. Controlling the geometry of the amides can lead to a diversity of diastereomeric structures. Here, we report for the first time that peptoid hexamers can adopt a unique looplike structure with a cis\u2013cis\u2013trans\u2013cis\u2013cis arrangement of the backbone amides. We found that a neutral zwitterionic state is necessary for the formation and stabilization of this structure by ion\u2013pair interaction between the positively and negatively charged N- and C-termini. The novel loop structure exhibits a remarkable stability in chloroform and acetonitrile. In methanol, the oligomers adopt the more common polyproline type I (PPI) helical conformation. A comprehensive NMR solution structure determination was carried out on a hexamer containing four central (S)\u2013N-(1-phenylethyl)glycines (Nspe) and two N-tert-butylglycines at the terminal ends. Our study reveals a distinct circular dichroism (CD) fingerprint for loop-shaped peptoids containing chiral aromatic Nspe monomers. The structure in solution was corroborated by a high-resolution crystal structure. Furthermore, we provide evidence that substituting the aromatic Nspe units with aliphatic (S)\u2013N-(1-cyclohexylethyl)glycines (Nsch) or (S)\u2013N-(1-tert-butylethyl)glycines (Nstbe) monomers does not impact loop folding processes. Finally, we demonstrate a reversible conformational switch between the loop structure and the PPI helix in response to external acid\u2013base stimuli. This reversible stimulus-driven structural reorganization opens up opportunities to develop on\/off switchable systems for next-generation smart applications.<\/jats:p>","DOI":"10.1021\/jacs.6c06943","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:14:29Z","timestamp":1785849269000},"page":"33251-33262","source":"Crossref","is-referenced-by-count":0,"title":["A Looplike Secondary\nStructure Uncovered in a Family\nof Peptoid Hexamers"],"prefix":"10.1021","volume":"148","author":[{"given":"Zacharie","family":"Bordas","sequence":"first","affiliation":[{"name":"Universite\u0301 Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF , ,","place":["Clermont-Ferrand, France, 63000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8931-7757","authenticated-orcid":true,"given":"Baptiste","family":"Legrand","sequence":"additional","affiliation":[{"name":"IBMM, Univ. Montpellier, CNRS, ENSCM , ,","place":["Montpellier, France, 34293"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souleymane","family":"Sarr","sequence":"additional","affiliation":[{"name":"Universite\u0301 Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF , ,","place":["Clermont-Ferrand, France, 63000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Biesse-Martin","sequence":"additional","affiliation":[{"name":"Universite\u0301 Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF , ,","place":["Clermont-Ferrand, France, 63000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Wenger","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lorraine, CNRS, CRM2 , ,","place":["Nancy, France, F-54000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Didierjean","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lorraine, CNRS, CRM2 , ,","place":["Nancy, France, F-54000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-8708","authenticated-orcid":true,"given":"Olivier","family":"Roy","sequence":"additional","affiliation":[{"name":"Universite\u0301 Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF , ,","place":["Clermont-Ferrand, France, 63000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-9481","authenticated-orcid":true,"given":"Sophie","family":"Faure","sequence":"additional","affiliation":[{"name":"Universite\u0301 Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF , ,","place":["Clermont-Ferrand, France, 63000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3126-495X","authenticated-orcid":true,"given":"Claude","family":"Taillefumier","sequence":"additional","affiliation":[{"name":"Universite\u0301 Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF , ,","place":["Clermont-Ferrand, France, 63000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"2026081210070689500_cit1","doi-asserted-by":"publisher","first-page":"9367","DOI":"10.1073\/pnas.89.20.9367","article-title":"Peptoids: a modular approach to drug discovery","volume":"89","author":"Simon","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026081210070689500_cit2","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/bip.21573","article-title":"Peptoid\nOrigins","volume":"96","author":"Zuckermann","year":"2011","journal-title":"Biopolymers"},{"key":"2026081210070689500_cit3","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.cbpa.2008.08.015","article-title":"Peptoid architectures: elaboration, actuation, and\napplication","volume":"12","author":"Yoo","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"2026081210070689500_cit4","first-page":"299","article-title":"Peptoids as potential\ntherapeutics","volume":"11","author":"Zuckermann","year":"2009","journal-title":"Curr. Opin. Mol. Ther."},{"key":"2026081210070689500_cit5","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.2174\/138161211797416066","article-title":"Peptoids:\nBio-inspired polymers as\npotential pharmaceuticals","volume":"17","author":"Dohm","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"2026081210070689500_cit6","doi-asserted-by":"publisher","first-page":"5665","DOI":"10.1002\/adma.201500275","article-title":"Sequence\nprogrammable peptoid polymers for diverse materials applications","volume":"27","author":"Knight","year":"2015","journal-title":"Adv. Mater."},{"key":"2026081210070689500_cit7","doi-asserted-by":"publisher","first-page":"14031","DOI":"10.1021\/acs.chemrev.1c00024","article-title":"Hierarchical Nanomaterials Assembled\nfrom Peptoids and Other Sequence-Defined Synthetic Polymers","volume":"121","author":"Li","year":"2021","journal-title":"Chem. Rev."},{"issue":"26","key":"2026081210070689500_cit8","doi-asserted-by":"publisher","first-page":"10646","DOI":"10.1021\/ja00052a076","article-title":"Efficient method\nfor the preparation of peptoids [oligo(N-substituted glycines)] by\nsubmonomer solid-phase synthesis","volume":"114","author":"Zuckermann","year":"1992","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026081210070689500_cit9","first-page":"241","article-title":"Submonomer\nsynthesis of sequence defined peptoids with diverse side-chains","volume-title":"Synthetic and enzymatic modifications of the peptide\nbackbone","author":"Connolly","year":"2021","edition":"656"},{"key":"2026081210070689500_cit10","doi-asserted-by":"publisher","first-page":"5282","DOI":"10.3390\/molecules15085282","article-title":"Solid-Phase Synthesis of N-Substituted Glycine Oligomers\n(alpha-Peptoids) and Derivatives","volume":"15","author":"Culf","year":"2010","journal-title":"Molecules"},{"key":"2026081210070689500_cit11","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00726-017-2385-6","article-title":"Recent\nadvances on polyproline II","volume":"49","author":"Narwani","year":"2017","journal-title":"Amino Acids"},{"key":"2026081210070689500_cit12","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1021\/acs.accounts.3c00772","article-title":"From Collagen\nMimetics to Collagen\nHybridization and Back","volume":"57","author":"Bhuket","year":"2024","journal-title":"Acc. Chem. Res."},{"key":"2026081210070689500_cit13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.31083\/j.fbl2806127","article-title":"Proline cis\/trans Isomerization in Intrinsically\nDisordered Proteins and Peptides","volume":"28","author":"Seba\u0301k","year":"2023","journal-title":"Front. Biosci.\n(Landmark Ed)"},{"key":"2026081210070689500_cit14","doi-asserted-by":"publisher","first-page":"12042","DOI":"10.1021\/ja0740925","article-title":"Kinetics and Equilibria of Cis\/Trans Isomerization of Backbone Amide Bonds in Peptoids","volume":"129","author":"Sui","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit15","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S1359-0278(97)00051-5","article-title":"Chiral N-substituted\nglycines can form stable helical conformations","volume":"2","author":"Armand","year":"1997","journal-title":"Fold. Des."},{"key":"2026081210070689500_cit16","doi-asserted-by":"publisher","first-page":"6778","DOI":"10.1021\/ja003154n","article-title":"Peptoid oligomers with \u03b1-chiral,\naromatic side\nchains: Sequence requirements for the formation of stable peptoid\nhelices","volume":"123","author":"Wu","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit17","doi-asserted-by":"publisher","first-page":"15559","DOI":"10.1021\/ja204755p","article-title":"Extraordinarily\nRobust Polyproline Type I Peptoid Helices Generated via the Incorporation\nof alpha-Chiral Aromatic N-1-Naphthylethyl Side Chains","volume":"133","author":"Stringer","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"38","key":"2026081210070689500_cit18","doi-asserted-by":"publisher","first-page":"13533","DOI":"10.1021\/jacs.7b07475","article-title":"Homogeneous\nand Robust Polyproline Type I Helices from\nPeptoids with Nonaromatic \u03b1-Chiral Side Chains","volume":"139","author":"Roy","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit19","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1021\/acs.orglett.6b01283","article-title":"Tandem Incorporation of Enantiomeric\nResidues Engenders Discrete Peptoid Structures","volume":"18","author":"Gorske","year":"2016","journal-title":"Org. Lett."},{"key":"2026081210070689500_cit20","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature15363","article-title":"Peptoid nanosheets exhibit a new\nsecondary-structure\nmotif","volume":"526","author":"Mannige","year":"2015","journal-title":"Nature"},{"key":"2026081210070689500_cit21","doi-asserted-by":"publisher","first-page":"16798","DOI":"10.1021\/ja905267k","article-title":"A Preliminary Survey of the Peptoid Folding Landscape","volume":"131","author":"Butterfoss","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit22","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202200149","article-title":"Strategies\nto Control the Cis-Trans Isomerization of Peptoid\nAmide Bonds","volume":"17","author":"Kalita","year":"2022","journal-title":"Chem. Asian J."},{"key":"2026081210070689500_cit23","doi-asserted-by":"publisher","first-page":"5079","DOI":"10.1002\/anie.201208630","article-title":"A Peptoid Ribbon Secondary Structure","volume":"52","author":"Crapster","year":"2013","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081210070689500_cit24","doi-asserted-by":"publisher","first-page":"8070","DOI":"10.1021\/jacs.7b02319","article-title":"Peptoid Square Helix\nvia Synergistic Control of Backbone Dihedral Angles","volume":"139","author":"Gorske","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit25","doi-asserted-by":"publisher","first-page":"8806","DOI":"10.1039\/C8SC04240C","article-title":"A bio-inspired\napproach to ligand design: folding single-chain peptoids to chelate\na multimetallic cluster","volume":"9","author":"Nguyen","year":"2018","journal-title":"Chem. Sci."},{"key":"2026081210070689500_cit26","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1039\/B810875G","article-title":"Metallopeptoids","author":"Maayan","year":"2009","journal-title":"Chem. Commun."},{"key":"2026081210070689500_cit27","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1039\/C2OB26764K","article-title":"Cyclopeptoids: a novel\nclass of phase-transfer catalysts","volume":"11","author":"Sala","year":"2013","journal-title":"Org. Biomol. Chem."},{"key":"2026081210070689500_cit28","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1002\/chem.201704497","article-title":"A Pure Polyproline\nType I-like Peptoid Helix by Metal Coordination","volume":"24","author":"Zborovsky","year":"2018","journal-title":"Chem. Eur J."},{"key":"2026081210070689500_cit29","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1039\/C8SC03616K","article-title":"Folding of\nunstructured peptoids and formation of hetero-bimetallic peptoid complexes\nupon side-chain-to-metal coordination","volume":"10","author":"Baskin","year":"2019","journal-title":"Chem.\nSci."},{"key":"2026081210070689500_cit30","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1039\/b806847j","article-title":"Stable helical\npeptoids via covalent side chain to\nside chain cyclization","volume":"6","author":"Vaz","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"2026081210070689500_cit31","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1039\/c2sc20473h","article-title":"Twice tied tight: Enforcing conformational\norder in bicyclic peptoid oligomers","volume":"3","author":"Vollrath","year":"2012","journal-title":"Chem. Sci."},{"key":"2026081210070689500_cit32","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1039\/C3CE42456A","article-title":"Solid state\nassembly of cyclic \u03b1-peptoids","volume":"16","author":"Tedesco","year":"2014","journal-title":"CrystEngComm"},{"key":"2026081210070689500_cit33","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1002\/ejoc.201901838","article-title":"The challenge of conformational isomerism in cyclic\npeptoids","volume":"2020","author":"De Riccardis","year":"2020","journal-title":"Eur. J. Org. Chem."},{"key":"2026081210070689500_cit34","doi-asserted-by":"publisher","first-page":"3218","DOI":"10.1021\/ja066960o","article-title":"Cyclic Peptoids","volume":"129","author":"Shin","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit35","doi-asserted-by":"publisher","first-page":"10911","DOI":"10.1021\/acs.joc.9b01509","article-title":"Reverse Turn\nand Loop Secondary Structures in Stereodefined Cyclic Peptoid Scaffolds","volume":"84","author":"D\u2019Amato","year":"2019","journal-title":"J. Org. Chem."},{"key":"2026081210070689500_cit36","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1021\/ja0574318","article-title":"A Threaded\nLoop Conformation Adopted by a Family of Peptoid Nonamers","volume":"128","author":"Huang","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit37","doi-asserted-by":"publisher","first-page":"14378","DOI":"10.1021\/ja065248o","article-title":"Tuning\nPeptoid Secondary Structure with Pentafluoroaromatic\nFunctionality: A New Design Paradigm for the Construction of Discretely\nFolded Peptoid Structures","volume":"128","author":"Gorske","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit38","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1021\/jo8023363","article-title":"Synthesis and Characterization of\nNitroaromatic Peptoids: Fine Tuning Peptoid Secondary Structure through\nMonomer Position and Functionality","volume":"74","author":"Fowler","year":"2009","journal-title":"J. Org.\nChem."},{"key":"2026081210070689500_cit39","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1039\/D2NR05326H","article-title":"Protein-mimetic\npeptoid nanoarchitectures for pathogen\nrecognition and neutralization","volume":"15","author":"Yang","year":"2023","journal-title":"Nanoscale"},{"key":"2026081210070689500_cit40","doi-asserted-by":"publisher","first-page":"16622","DOI":"10.1021\/ja804580n","article-title":"Oligo(N-aryl glycines): A New Twist on Structured Peptoids","volume":"130","author":"Shah","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit41","doi-asserted-by":"publisher","first-page":"8401","DOI":"10.1039\/D1SC00717C","article-title":"Submonomer\nsynthesis of peptoids containing trans-inducing N-imino- and N-alkylamino-glycines","volume":"12","author":"Davern","year":"2021","journal-title":"Chem. Sci."},{"key":"2026081210070689500_cit42","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3762\/bjoc.18.85","article-title":"First series of N-alkylamino\npeptoid homooligomers: solution phase synthesis and conformational\ninvestigation","volume":"18","author":"Pypec","year":"2022","journal-title":"Beilstein J. Org. Chem."},{"key":"2026081210070689500_cit43","doi-asserted-by":"publisher","first-page":"16555","DOI":"10.1021\/ja907184g","article-title":"New Strategies\nfor the Design of Folded Peptoids Revealed by a Survey of Noncovalent\nInteractions in Model Systems","volume":"131","author":"Gorske","year":"2009","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026081210070689500_cit44","doi-asserted-by":"publisher","first-page":"15559","DOI":"10.1021\/ja204755p","article-title":"Extraordinarily\nRobust Polyproline Type I Peptoid Helices Generated via the Incorporation\nof \u03b1-Chiral Aromatic N-1-Naphthylethyl Side Chains","volume":"133","author":"Stringer","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit45","doi-asserted-by":"publisher","first-page":"5118","DOI":"10.1021\/ol4025502","article-title":"Self-Association\nof Water-Soluble Peptoids Comprising (S)-N-1-(Naphthylethyl)glycine\nResidues","volume":"15","author":"Fuller","year":"2013","journal-title":"Org. Lett."},{"key":"2026081210070689500_cit46","doi-asserted-by":"publisher","first-page":"3762","DOI":"10.1021\/acs.joc.9b00218","article-title":"Functionalized Helical \u03b2-Peptoids","volume":"84","author":"Wellho\u0308fer","year":"2019","journal-title":"J. Org. Chem."},{"key":"2026081210070689500_cit47","doi-asserted-by":"publisher","first-page":"9553","DOI":"10.1021\/ja302342h","article-title":"The Click Triazolium Peptoid Side\nChain: A Strong cis-Amide Inducer Enabling Chemical Diversity","volume":"134","author":"Caumes","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit48","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1021\/acs.joc.6b02804","article-title":"1,2,3-Triazolium-Based\nPeptoid Oligomers","volume":"82","author":"Aliouat","year":"2017","journal-title":"J.\nOrg. Chem."},{"key":"2026081210070689500_cit49","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1002\/cmdc.201800273","article-title":"1,2,3-Triazolium-Based\nCationic Amphipathic Peptoid Oligomers Mimicking Antimicrobial Helical\nPeptides","volume":"13","author":"Shyam","year":"2018","journal-title":"ChemMedChem"},{"key":"2026081210070689500_cit50","doi-asserted-by":"publisher","first-page":"19436","DOI":"10.1021\/jacs.9b10497","article-title":"Cooperative\nIntramolecular Hydrogen Bonding Strongly Enforces cis-Peptoid Folding","volume":"141","author":"Wijaya","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"2026081210070689500_cit51","doi-asserted-by":"publisher","first-page":"10549","DOI":"10.1002\/anie.201804488","article-title":"Stabilising Peptoid\nHelices Using Non-Chiral Fluoroalkyl Monomers","volume":"57","author":"Gimenez","year":"2018","journal-title":"Angew. Chemie Int. Ed."},{"key":"2026081210070689500_cit52","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1021\/ol400820y","article-title":"The tert-Butyl\nSide Chain: A Powerful\nMeans to Lock Peptoid Amide Bonds in the Cis Conformation","volume":"15","author":"Roy","year":"2013","journal-title":"Org. Lett."},{"key":"2026081210070689500_cit53","doi-asserted-by":"publisher","DOI":"10.1002\/bip.23273","article-title":"NC\u03b1-gem-dimethylated\npeptoid side chains:\nA novel approach for structural control and peptide sequence mimetics","volume":"110","author":"Shyam","year":"2019","journal-title":"Biopolymers"},{"key":"2026081210070689500_cit54","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.1021\/acs.joc.5c00009","article-title":"Solid-Phase\nSynthesis of Peptoid Oligomers Containing Crowded tert-Butyl Side Chains","volume":"90","author":"Bordas","year":"2025","journal-title":"J. Org. Chem."},{"key":"2026081210070689500_cit55","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1021\/acs.joc.9b02916","article-title":"Strengthening\nPeptoid Helicity through Sequence Site-Specific\nPositioning of Amide cis-Inducing NtBu Monomers","volume":"85","author":"Rzeigui","year":"2020","journal-title":"J. Org. Chem."},{"key":"2026081210070689500_cit56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/A:1009698309407","article-title":"NMR structural characterization of oligo-N-substituted\nglycine lead compounds from a combinatorial library","volume":"3","author":"Bradley","year":"1997","journal-title":"Mol. Diversity"},{"key":"2026081210070689500_cit57","doi-asserted-by":"publisher","first-page":"4309","DOI":"10.1073\/pnas.95.8.4309","article-title":"NMR determination\nof the major solution conformation of a peptoid pentamer with chiral\nside chains","volume":"95","author":"Armand","year":"1998","journal-title":"Proc. Natl. Acad. Sci. 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