{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:39:23Z","timestamp":1788478763805,"version":"build-2803163510"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100006221","name":"United States - Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["2023787"],"award-info":[{"award-number":["2023787"]}],"id":[{"id":"10.13039\/100006221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation (NSF)","doi-asserted-by":"crossref","award":["CHE-2513261"],"award-info":[{"award-number":["CHE-2513261"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The chirality-induced spin selectivity (CISS) effect has been invoked to explain recent reports of differences in the time-resolved EPR signals between chiral and achiral molecules. However, the microscopic origin of these differences and their connection to CISS remain contested, particularly since these systems lack a metal interface. Here, we introduce an intramolecular spinterface-like mechanism that naturally arises within donor\u2013chiral bridge\u2013acceptor (D\u2212\u03c7B\u2013A) complexes and quantitatively reproduces experimentally reported observed spin polarization in time-resolved EPR studies. In our two-electron Lindblad model, the photoexcited charge-transfer electron traversing the chiral bridge exchanges with the residual donor electron, which acts as a localized magnetic moment analogous to an induced magnetic moment on an electrode surface. The resulting through-bridge charge current produces an effective solenoidal field at the donor\u2013bridge interface, breaking spin degeneracy and directional symmetry, thus enabling spin-selective transport without invoking intrinsic spin\u2013orbit coupling on the bridge. We show that the interplay among this current-induced field, donor thermalization (which breaks time-reversal symmetry), and bridge spin mixing yields tens-of-percent polarization over realistic experimental conditions and charge-transfer time scales, matching reported CISS signatures in triads and DNA hairpins. By explicitly resolving the dependence on solenoidal coupling strength, temperature, and spin-mixing rates, the model identifies the regime in which internal spinterfaces can generate robust CISS-like spin filtering. These findings demonstrate that CISS-like signals in isolated D\u2212\u03c7B\u2013A complexes are fully compatible with a spinterface mechanism, providing a unified conceptual framework for interpreting both device-based and molecule-internal CISS platforms.<\/jats:p>","DOI":"10.1021\/jacs.6c07331","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:42:18Z","timestamp":1784090538000},"page":"31200-31208","source":"Crossref","is-referenced-by-count":1,"title":["Spinterface-like Mechanism\nof the Chirality-Induced\nSpin Selectivity in Donor\u2013Chiral Bridge\u2013Acceptor Complexes"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7260-5100","authenticated-orcid":true,"given":"Subhajit","family":"Sarkar","sequence":"first","affiliation":[{"name":"Shiv Nadar Institution of Eminence Deemed to be University , , NH91, Tehsil Dadri , , ,","place":["Gautam Buddha Nagar, Uttar Pradesh, India, 201314"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-7253","authenticated-orcid":true,"given":"Oliver L. A.","family":"Monti","sequence":"additional","affiliation":[{"name":"University of Arizona , , 1306 E. University Blvd. , , ,","place":["Tucson, Arizona, United States, 85721"]},{"name":"University of Arizona , , 1118 E. Fourth Street , , ,","place":["Tucson, Arizona, United States, 85721"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8988-4935","authenticated-orcid":true,"given":"Yonatan","family":"Dubi","sequence":"additional","affiliation":[{"name":"Ben-Gurion University of the Negev , , ,","place":["Beer Sheva, Israel, 84105"]},{"name":"Ben-Gurion University of the Negev , , ,","place":["Beer Sheva, Israel, 84105"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2026073021265165000_cit1","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1126\/science.283.5403.814","article-title":"Asymmetric Scattering\nof Polarized Electrons by Organized Organic Films of Chiral Molecules","volume":"283","author":"Ray","year":"1999","journal-title":"Science"},{"key":"2026073021265165000_cit2","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1021\/acs.chemrev.3c00661","article-title":"Chiral\nInduced Spin\nSelectivity","volume":"124","author":"Bloom","year":"2024","journal-title":"Chem. Rev."},{"key":"2026073021265165000_cit3","doi-asserted-by":"publisher","first-page":"4989","DOI":"10.1021\/acsnano.1c01347","article-title":"A Chirality-Based Quantum\nLeap","volume":"16","author":"Aiello","year":"2022","journal-title":"ACS Nano"},{"key":"2026073021265165000_cit4","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106629","article-title":"Theory of\nChirality\nInduced Spin Selectivity: Progress and Challenges","volume":"34","author":"Evers","year":"2022","journal-title":"Adv. Mater."},{"key":"2026073021265165000_cit5","doi-asserted-by":"publisher","first-page":"37484","DOI":"10.1021\/acsnano.5c16086","article-title":"The Spinterface Mechanism\nfor the Chiral-Induced Spin Selectivity Effect: A Critical Perspective","volume":"19","author":"Sarkar","year":"2025","journal-title":"ACS Nano"},{"key":"2026073021265165000_cit6","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwae212","article-title":"A chemical perspective\non the chiral induced spin selectivity effect","volume":"11","author":"Bloom","year":"2024","journal-title":"Natl. Sci. Rev."},{"key":"2026073021265165000_cit7","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300472","article-title":"Chirality-Induced\nSpin Selectivity: An Enabling Technology for Quantum Applications","volume":"35","author":"Chiesa","year":"2023","journal-title":"Adv. Mater."},{"key":"2026073021265165000_cit8","doi-asserted-by":"publisher","first-page":"14905","DOI":"10.1039\/D4SC04435E","article-title":"The mechanism\nof the molecular CISS effect in chiral\nnano-junctions","volume":"15","author":"Nguyen","year":"2024","journal-title":"Chemical Science"},{"key":"2026073021265165000_cit9","doi-asserted-by":"publisher","first-page":"36453","DOI":"10.1021\/jacs.5c10892","article-title":"Dipole-Induced\nInversion\nof Spin-Dependent Charge Transport through \u03b1-Helical Peptide-Based\nSingle-Molecule Junctions","volume":"147","author":"Aragone\u0300s","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026073021265165000_cit10","doi-asserted-by":"publisher","first-page":"14235","DOI":"10.1021\/jacs.1c05637","article-title":"Spinterface Origin\nfor the Chirality-Induced Spin-Selectivity Effect","volume":"143","author":"Alwan","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"2026073021265165000_cit11","doi-asserted-by":"publisher","first-page":"10878","DOI":"10.1039\/d2sc02565e","article-title":"Spinterface\nchirality-induced spin selectivity effect in bio-molecules","volume":"13","author":"Dubi","year":"2022","journal-title":"Chem. Sci."},{"key":"2026073021265165000_cit12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1126\/science.adj5328","article-title":"Direct\nobservation of chirality-induced spin selectivity in electron donor\u2013acceptor\nmolecules","volume":"382","author":"Eckvahl","year":"2023","journal-title":"Science"},{"key":"2026073021265165000_cit13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2515120122","article-title":"Detecting chirality-induced spin selectivity in chromophore-linked\nDNA hairpins using photogenerated radical pairs","volume":"122","author":"Latawiec","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026073021265165000_cit14","doi-asserted-by":"publisher","first-page":"24125","DOI":"10.1021\/jacs.4c08706","article-title":"Detecting Chirality-Induced Spin Selectivity in Randomly\nOriented Radical Pairs Photogenerated by Hole Transfer","volume":"146","author":"Eckvahl","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"2026073021265165000_cit15","doi-asserted-by":"publisher","first-page":"15193","DOI":"10.1021\/jacs.6c01757","article-title":"Chirality-Induced Spin Selectivity\nin an Achiral Electron Donor\u2013Acceptor Molecule Doped into a\nCholesteric Liquid Crystal","volume":"148","author":"Eckvahl","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026073021265165000_cit16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2519806122","article-title":"Probing the connection between chirality\nand spin through\ntime-resolved EPR spectroscopy","volume":"122","author":"Saxena","year":"2025","journal-title":"Proc. Natl.\nAcad. Sci. U. S. A."},{"key":"2026073021265165000_cit17","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1126\/science.adk5634","article-title":"Chiral\nmolecules to transmit electron spin","volume":"382","author":"Subotnik","year":"2023","journal-title":"Science"},{"key":"2026073021265165000_cit18","doi-asserted-by":"publisher","first-page":"12208","DOI":"10.1039\/D2SC03712B","article-title":"Direct detection of\nspin polarization in photoinduced charge transfer\nthrough a chiral bridge","volume":"13","author":"Privitera","year":"2022","journal-title":"Chemical Science"},{"key":"2026073021265165000_cit19","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202301005","article-title":"Challenges in the Direct Detection\nof Chirality-induced Spin Selectivity: Investigation of Foldamer-based\nDonor-acceptor Dyads","volume":"29","author":"Privitera","year":"2023","journal-title":"Chem. \u2212Eur. J."},{"key":"2026073021265165000_cit20","doi-asserted-by":"publisher","first-page":"9727","DOI":"10.1021\/acs.jpclett.3c02546","article-title":"Comparing electrical magnetochiral\nanisotropy and chirality-induced\nspin selectivity","volume":"14","author":"Rikken","year":"2023","journal-title":"journal of physical chemistry\nletters"},{"key":"2026073021265165000_cit21","doi-asserted-by":"publisher","first-page":"12133","DOI":"10.1021\/acs.nanolett.4c02912","article-title":"Many-body\nmodels for chirality-induced spin selectivity in electron transfer","volume":"24","author":"Chiesa","year":"2024","journal-title":"Nano Lett."},{"key":"2026073021265165000_cit22","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.111.205417","article-title":"Dynamical\ntheory of chiral-induced\nspin selectivity in electron donor\u2013chiral molecule\u2013acceptor\nsystems","volume":"111","author":"Zhang","year":"2025","journal-title":"Phys. Rev. B"},{"key":"2026073021265165000_cit23","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.106.064409","article-title":"Role of chiral-induced\nspin selectivity in the radical\npair mechanism of avian magnetoreception","volume":"106","author":"Tiwari","year":"2022","journal-title":"Phys.\nRev. E"},{"key":"2026073021265165000_cit24","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aec7069","article-title":"PT symmetry enforced twin exchange\nas the origin of chirality-induced spin selectivity","volume":"12","author":"Theiler","year":"2026","journal-title":"Sci. Adv."},{"key":"2026073021265165000_cit25","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1146\/annurev-physchem-083122-125320","article-title":"Theories of Chiral-Induced Spin Selectivity: A Pedagogical\nOverview","volume":"77","author":"Nuomin","year":"2026","journal-title":"Annu. Rev. Phys. Chem."},{"key":"2026073021265165000_cit26","doi-asserted-by":"publisher","first-page":"32795","DOI":"10.1021\/jacs.4c12974","article-title":"Surface Magnetic Stabilization\nand the Photoemission Chiral-Induced\nSpin-Selectivity Effect","volume":"146","author":"Monti","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"2026073021265165000_cit27","doi-asserted-by":"publisher","first-page":"6696","DOI":"10.1021\/acs.nanolett.1c02370","article-title":"Origin of Chirality\nInduced Spin Selectivity in Photoinduced\nElectron Transfer","volume":"21","author":"Fay","year":"2021","journal-title":"Nano Lett."},{"key":"2026073021265165000_cit28","doi-asserted-by":"publisher","DOI":"10.1088\/1367-2630\/abed0b","article-title":"Chiral-induced spin\nselectivity in the formation and\nrecombination of radical pairs: cryptochrome magnetoreception and\nEPR detection","volume":"23","author":"Luo","year":"2021","journal-title":"New J. Phys."},{"key":"2026073021265165000_cit29","doi-asserted-by":"publisher","first-page":"9414","DOI":"10.1021\/acs.jpclett.5c02119","article-title":"Enantioselective\nRadical Reactions Can Be Induced by Electron Spin Polarization: A\nQuantum Mechanism for Nature\u2019s Emergent Homochirality?","volume":"16","author":"Fay","year":"2025","journal-title":"J. Phys. Chem. Lett."},{"key":"2026073021265165000_cit30","doi-asserted-by":"publisher","DOI":"10.1063\/1.5095204","article-title":"Radical pair intersystem crossing:\nQuantum dynamics\nor incoherent kinetics?","volume":"150","author":"Fay","year":"2019","journal-title":"J. Chem. Phys."},{"key":"2026073021265165000_cit31","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1021\/acs.jpclett.1c00009","article-title":"Chirality-Induced\nSpin Coherence in Electron Transfer Reactions","volume":"12","author":"Fay","year":"2021","journal-title":"J. Phys. Chem. Lett."},{"key":"2026073021265165000_cit32","doi-asserted-by":"publisher","DOI":"10.1063\/1.5125752","article-title":"Electron\nspin relaxation in radical\npairs: Beyond the Redfield approximation","volume":"151","author":"Fay","year":"2019","journal-title":"J.\nChem. Phys."},{"key":"2026073021265165000_cit33","doi-asserted-by":"publisher","first-page":"10988","DOI":"10.1021\/jp801646g","article-title":"Charge Transfer\nin Donor-Bridge-Acceptor Systems: Static Disorder, Dynamic Fluctuations,\nand Complex Kinetics","volume":"112","author":"Berlin","year":"2008","journal-title":"J. Phys. Chem. C"},{"key":"2026073021265165000_cit34","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/S0301-0104(01)00300-7","article-title":"Steady-state quantum\nmechanics of thermally relaxing\nsystems","volume":"268","author":"Segal","year":"2001","journal-title":"Chem. Phys."},{"key":"2026073021265165000_cit35","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/BF01608499","article-title":"On the generators\nof quantum dynamical semigroups","volume":"48","author":"Lindblad","year":"1976","journal-title":"Communications\nin Mathematical Physics"},{"key":"2026073021265165000_cit36","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1063\/1.522979","article-title":"Completely positive dynamical semigroups\nof N-level systems","volume":"17","author":"Gorini","year":"1976","journal-title":"Journal of Mathematical\nPhysics"},{"key":"2026073021265165000_cit37","doi-asserted-by":"publisher","DOI":"10.1063\/1.5115323","article-title":"A short introduction\nto the Lindblad master equation","volume":"10","author":"Manzano","year":"2020","journal-title":"AIP Adv."},{"key":"2026073021265165000_cit38","doi-asserted-by":"publisher","first-page":"15115","DOI":"10.1021\/acs.jpcc.0c04581","article-title":"Environment-assisted and environment-hampered efficiency at maximum\npower in a molecular photocell","volume":"124","author":"Sarkar","year":"2020","journal-title":"J. Phys. Chem.\nC"},{"key":"2026073021265165000_cit39","doi-asserted-by":"publisher","first-page":"184112","DOI":"10.1063\/5.0005412","article-title":"Ballistic\ntransport and quantum unfurling in molecular\njunctions via minimal representations of quantum master equations","volume":"152","author":"Iv","year":"2020","journal-title":"J. Chem. Phys."},{"key":"2026073021265165000_cit40","doi-asserted-by":"publisher","first-page":"194308","DOI":"10.1063\/1.4921310","article-title":"Continuum model for\nchiral induced\nspin selectivity in helical molecules","volume":"142","author":"Medina","year":"2015","journal-title":"J. Chem.\nPhys."},{"key":"2026073021265165000_cit41","doi-asserted-by":"publisher","first-page":"411","DOI":"10.2533\/chimia.2018.411","article-title":"Spin-orbit coupling modulation in\nDNA by mechanical deformations","volume":"72","author":"Salazar","year":"2018","journal-title":"Chimia"},{"key":"2026073021265165000_cit42","doi-asserted-by":"publisher","first-page":"124119","DOI":"10.1063\/5.0272982","article-title":"Toward a formulation\nof a CISS theory with the inclusion of two-particle relativistic effects,\nelectron\u2013phonon coupling, and electron\u2013electron correlation.\nAn application to NMR-based chiral discrimination","volume":"163","author":"Luden\u0303a","year":"2025","journal-title":"J. Chem. Phys."},{"key":"2026073021265165000_cit43","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.102.235416","article-title":"Vibrational\norigin of exchange splitting and\u201d chiral-induced spin selectivity","volume":"102","author":"Fransson","year":"2020","journal-title":"Phys. Rev. B"},{"key":"2026073021265165000_cit44","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nnano.2011.48","article-title":"DNA spintronics sees the light","volume":"6","author":"Di Ventra","year":"2011","journal-title":"Nature Nanotechnol."},{"key":"2026073021265165000_cit45","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s43246-025-00821-3","article-title":"Ab initio\nparametrization of a generalized Hubbard model in a molecule displaying\nchirality-induced spin selectivity","volume":"6","author":"Phan Huu","year":"2025","journal-title":"Commun.\nMater."},{"key":"2026073021265165000_cit46","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1529\/biophysj.107.119362","article-title":"Role of exchange and\ndipolar interactions in the radical pair model\nof the avian magnetic compass","volume":"94","author":"Efimova","year":"2008","journal-title":"Biophysical journal"},{"key":"2026073021265165000_cit47","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1039\/D2CP03793A","article-title":"Magnetic field\neffects on radical\npair reactions: estimation of B 1\/2 for flavin-tryptophan radical\npairs in cryptochromes","volume":"25","author":"Wong","year":"2023","journal-title":"Phys. Chem. Chem. Phys."},{"key":"2026073021265165000_cit48","doi-asserted-by":"publisher","first-page":"3026","DOI":"10.1021\/acs.nanolett.1c00183","article-title":"Charge Redistribution\nand Spin Polarization Driven by Correlation Induced Electron Exchange\nin Chiral Molecules","volume":"21","author":"Fransson","year":"2021","journal-title":"Nano Lett."},{"key":"2026073021265165000_cit49","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.202200046","article-title":"The Chiral\nInduced Spin Selectivity Effect What It Is, What It Is Not, And Why\nIt Matters","volume":"62","author":"Fransson","year":"2022","journal-title":"Isr. J. Chem."}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c07331","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/29\/31200\/66344304\/jacs.6c07331.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/29\/31200\/66344304\/jacs.6c07331.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:11:05Z","timestamp":1785485465000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/29\/31200\/5237490\/Spinterface-like-Mechanism-of-the-Chirality"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":49,"journal-issue":{"issue":"29","published-online":{"date-parts":[[2026,7,15]]},"published-print":{"date-parts":[[2026,7,29]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c07331","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]}}}