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However, studies on nonbenzenoid conjugated polyene aromatic molecules remain scarce, largely due to synthetic challenges and inherent angle strain. Herein, we report an unprecedented single-copper relay dual-catalyzed cascade sequence for the efficient construction of a unique aromatic N-bridged [10]annulene (NBA) framework (also called cycl[3,2,2]azine), in which a copper-catalyzed 10\u03c0 electrocyclization is involved. To gain insight into the reaction mechanism, a series of control experiments and density functional theory calculations were conducted. The developed reaction exhibits broad functional-group tolerance and can be extended to different classes of 14\u03c0 components. Significantly, the resulting NBA compounds display strong fluorescence with full-color tunability. Therefore, these innovations not only deepen our understanding of the aromaticity of nonbenzenoid systems but also highlight the potential of metal-catalyzed electrocyclization in synthetic chemistry.<\/jats:p>","DOI":"10.1021\/jacs.6c07345","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:19:02Z","timestamp":1784153942000},"page":"31190-31199","source":"Crossref","is-referenced-by-count":1,"title":["Efficient Synthesis\nof N-Bridged Annulenes"],"prefix":"10.1021","volume":"148","author":[{"given":"Jianwei","family":"Liu","sequence":"first","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 40044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6377-368X","authenticated-orcid":true,"given":"Shiqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Renmin University of China , , ,","place":["Beijing, China, 100872"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Sun","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 40044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Cheng","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 40044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangshen","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 40044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaihang","family":"Li","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6953-687X","authenticated-orcid":true,"given":"Baosheng","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 40044"]},{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2026073021265277200_cit1","doi-asserted-by":"publisher","first-page":"5845","DOI":"10.1021\/jm4017625","article-title":"Rings in Drugs","volume":"57","author":"Taylor","year":"2014","journal-title":"J. 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