{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:18:28Z","timestamp":1788254308051,"version":"build-2803163510"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"German Research Council","doi-asserted-by":"publisher","award":["EXC-2082\/2-390761711"],"award-info":[{"award-number":["EXC-2082\/2-390761711"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>X-yne nucleophilic addition reactions are essential and powerful tools in a range of synthetic routes for realizing functional and stimuli-responsive materials. Unfortunately, the lack of spatiotemporal control and the requirement for catalyst addition in these reactions limit their full potential in synthetic and materials-based applications, including in light-driven 3D printing. Herein, we close this critical gap and exploit a spirothiopyran (STP) photoswitch as a synthon for photoinduced and catalyst-free thiol\u2013yne click reactions, an important class of X-yne click chemistries. We further employ our photoswitch-based entity for rapid and facile postpolymerization modification as well as photopolymerization under very mild and aerobic conditions.<\/jats:p>","DOI":"10.1021\/jacs.6c09543","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:02:08Z","timestamp":1786719728000},"page":"35908-35915","source":"Crossref","is-referenced-by-count":0,"title":["Catalyst-Free\nThiol\u2013yne Nucleophilic Photoclick\nChemistry"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2256-0423","authenticated-orcid":true,"given":"Linh Duy","family":"Thai","sequence":"first","affiliation":[{"name":"Karlsruhe Institute of Technology (KIT) , , Hermann-von-Helmholtz-Platz 1 , ,","place":["Eggenstein-Leopoldshafen, Germany, 76344"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Kirschho\u0308fer","sequence":"additional","affiliation":[{"name":"Karlsruhe Institute of Technology (KIT) , , Hermann-von-Helmholtz-Platz 1 , ,","place":["Eggenstein-Leopoldshafen, Germany, 76344"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8877-8603","authenticated-orcid":true,"given":"Sebastian","family":"Roth","sequence":"additional","affiliation":[{"name":"Karlsruhe Institute of Technology (KIT) , , Hermann-von-Helmholtz-Platz 1 , ,","place":["Eggenstein-Leopoldshafen, Germany, 76344"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6745-0570","authenticated-orcid":true,"given":"Christopher","family":"Barner-Kowollik","sequence":"additional","affiliation":[{"name":"Karlsruhe Institute of Technology (KIT) , , Hermann-von-Helmholtz-Platz 1 , ,","place":["Eggenstein-Leopoldshafen, Germany, 76344"]},{"name":"Queensland University of Technology (QUT) , , 2 George Street , , ,","place":["Brisbane, QLD, Australia, 4000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"issue":"23","key":"2026090104492298100_cit1","doi-asserted-by":"publisher","first-page":"4745","DOI":"10.1039\/b917102a","article-title":"Thiol-yne\nclick chemistry: A powerful\nand versatile methodology for materials synthesis","volume":"20","author":"Lowe","year":"2010","journal-title":"J. Mater. Chem."},{"issue":"12","key":"2026090104492298100_cit2","doi-asserted-by":"publisher","first-page":"6744","DOI":"10.1021\/acs.chemrev.0c01076","article-title":"Click nucleophilic\nconjugate additions to activated alkynes: exploring thiol-yne, amino-yne,\nand hydroxyl-yne reactions from (bio) organic to polymer chemistry","volume":"121","author":"Worch","year":"2021","journal-title":"Chem. Rev."},{"issue":"29","key":"2026090104492298100_cit3","doi-asserted-by":"publisher","first-page":"7087","DOI":"10.1002\/chem.201700572","article-title":"Application of\nthiol\u2013yne\/thiol\u2013ene reactions for peptide and protein\nmacrocyclizations","volume":"23","author":"Wang","year":"2017","journal-title":"Chem. \u2013 Eur. J."},{"issue":"8","key":"2026090104492298100_cit4","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1021\/cr0783479","article-title":"Cu-catalyzed\nazide\u2013 alkyne cycloaddition","volume":"108","author":"Meldal","year":"2008","journal-title":"Chem. 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Rapid Commun."},{"issue":"2","key":"2026090104492298100_cit37","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1021\/acsmacrolett.7b01001","article-title":"Light-induced\nstep-growth polymerization of AB-type photo-monomers at ambient temperature","volume":"7","author":"Hurrle","year":"2018","journal-title":"ACS Macro Lett."},{"issue":"40","key":"2026090104492298100_cit38","doi-asserted-by":"publisher","first-page":"6435","DOI":"10.1039\/D0PY01119C","article-title":"Visible-light\nreversible photopolymerisation: insights via online photoflow\u2013electrospray\nionisation\u2013mass spectrometry","volume":"11","author":"Van De Walle","year":"2020","journal-title":"Polym.\nChem."}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c09543","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/33\/35908\/66545492\/jacs.6c09543.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/33\/35908\/66545492\/jacs.6c09543.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:49:39Z","timestamp":1788252579000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/33\/35908\/5255415\/Catalyst-Free-Thiol-yne-Nucleophilic-Photoclick"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":38,"journal-issue":{"issue":"33","published-online":{"date-parts":[[2026,8,14]]},"published-print":{"date-parts":[[2026,8,26]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c09543","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]}}}