{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:55:20Z","timestamp":1792598120362,"version":"4.5.0"},"reference-count":93,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21CA277152"],"award-info":[{"award-number":["R21CA277152"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza Universit? di Roma","doi-asserted-by":"publisher","award":["GA12117A8711CC9F"],"award-info":[{"award-number":["GA12117A8711CC9F"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004710","name":"Fondazione Umberto Veronesi","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100004710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 2024-31139"],"award-info":[{"award-number":["IG 2024-31139"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>RNA N6-methyladenosine (m6A) deposition by the METTL3\u2013METTL14 complex regulates RNA metabolism and thereby influences cell differentiation and stress responses. Dysregulated m6A deposition has been implicated in multiple cancers, where METTL3\u2013METTL14 supports oncogenic programs. Yet the molecular basis of RNA recognition by this complex remains unclear, in part due to the lack of an RNA-bound structure of the full assembly. Here, we combined native mass spectrometry (MS), molecular modeling, biochemical assays, and cell-based studies to define how METTL3\u2013METTL14 engages RNA and how this process can be perturbed through interface targeting. Native MS of the intact heterodimer revealed simultaneous binding of multiple RNA molecules, with RNA-dependent stoichiometries and higher-occupancy states consistent with cooperative interactions. Molecular dynamics simulations identified a structured RNA-bound assembly in which the METTL14 C-terminal RGG-rich region stabilizes two RNA molecules, supporting a pre-engaged substrate configuration. We further developed a focused library of METTL14-derived peptides that bind METTL3 and interfere with protein\u2013protein interactions, identifying the minimal METTL14 epitope for interface engagement. The most potent peptide, R8\u201314, binds with submicromolar affinity, disrupts both METTL3\u2013METTL14 association and higher-order RNA-bound states, and reduces m6A levels, c-Myc expression, and cancer cell viability. Together, these findings demonstrate that RNA recognition by METTL3\u2013METTL14 is governed by multivalent, higher-order interactions that enhance binding avidity. Notably, this assembly can be perturbed allosterically through protein\u2013protein interface targeting rather than active-site inhibition, highlighting multivalent RNA recognition as a mechanistically and pharmacologically actionable feature of the RNA m6A writer complex.<\/jats:p>","DOI":"10.1021\/jacs.6c09634","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:01:37Z","timestamp":1791367297000},"page":"44138-44155","source":"Crossref","is-referenced-by-count":0,"title":["METTL3\u2013METTL14\nHeterodimer Assembly Enables\nMultivalent RNA Engagement and Is Tuned by Interface-Targeting Peptides"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-1860","authenticated-orcid":true,"given":"Francesco","family":"Fiorentino","sequence":"first","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1087-3969","authenticated-orcid":true,"given":"Boyi","family":"Xiao","sequence":"additional","affiliation":[{"name":"University of Bristol , , Biomedical Sciences Building, University Walk , ,","place":["Bristol, U.K., BS8 1TD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Cesaro","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Venezia","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4104-7158","authenticated-orcid":true,"given":"Jujun","family":"Zhou","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center , , , ,","place":["Houston, Texas, United States, 77030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Fabbrizi","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Casano","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-3214","authenticated-orcid":true,"given":"Gebremedhin Solomon","family":"Hailu","sequence":"additional","affiliation":[{"name":"Roma Tre University , , Viale Marconi 446 , ,","place":["Rome, Italy, 00146"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6967-6362","authenticated-orcid":true,"given":"Xiaodong","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center , , , ,","place":["Houston, Texas, United States, 77030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1820-7993","authenticated-orcid":true,"given":"Robin A.","family":"Corey","sequence":"additional","affiliation":[{"name":"University of Bristol , , Biomedical Sciences Building, University Walk , ,","place":["Bristol, U.K., BS8 1TD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0743-7905","authenticated-orcid":true,"given":"Alessandro","family":"Fatica","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-2382","authenticated-orcid":true,"given":"Antonello","family":"Mai","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3152-4467","authenticated-orcid":true,"given":"Stefano","family":"Tomassi","sequence":"additional","affiliation":[{"name":"Link Campus University , , Via del Casale di S. Pio V, 44 , ,","place":["Roma, Italy, 00165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-8763","authenticated-orcid":true,"given":"Dante","family":"Rotili","sequence":"additional","affiliation":[{"name":"Roma Tre University , , Viale Marconi 446 , ,","place":["Rome, Italy, 00146"]},{"name":"Biostructures and Biosystems National Institute (INBB) , Via dei Carpegna 19 , ,","place":["Rome, Italy, 00165"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"issue":"10","key":"2026102111064069700_cit1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-10-175","article-title":"The birth of the\nEpitranscriptome: deciphering the\nfunction of RNA modifications","volume":"13","author":"Saletore","year":"2012","journal-title":"Genome Biol."},{"key":"2026102111064069700_cit2","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41568-025-00889-6","article-title":"N6-Methyladenosine: an RNA modification\nas a central regulator of cancer","volume":"26","author":"Luo","year":"2025","journal-title":"Nat. Rev.\nCancer"},{"issue":"7","key":"2026102111064069700_cit3","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive Analysis of mRNA Methylation\nReveals\nEnrichment in 3\u2032 UTRs and near Stop Codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"issue":"2","key":"2026102111064069700_cit4","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3\u2013METTL14 complex mediates\nmammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"issue":"26","key":"2026102111064069700_cit5","doi-asserted-by":"publisher","first-page":"17697","DOI":"10.1016\/S0021-9258(17)32497-3","article-title":"Characterization\nand partial purification of mRNA N6-adenosine methyltransferase from\nHeLa cell nuclei. Internal mRNA methylation requires a multisubunit\ncomplex","volume":"269","author":"Bokar","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"8","key":"2026102111064069700_cit6","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/nmeth.3453","article-title":"Single-nucleotide-resolution\nmapping of m6A and m6Am\nthroughout the transcriptome","volume":"12","author":"Linder","year":"2015","journal-title":"Nat. Methods"},{"issue":"2","key":"2026102111064069700_cit7","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.molcel.2016.05.041","article-title":"Structural\nBasis for Cooperative\nFunction of Mettl3 and Mettl14 Methyltransferases","volume":"63","author":"Wang","year":"2016","journal-title":"Mol. Cell"},{"issue":"7608","key":"2026102111064069700_cit8","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nature18298","article-title":"Structural\nbasis of N(6)-adenosine methylation by the\nMETTL3-METTL14 complex","volume":"534","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"2026102111064069700_cit9","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18434.001","article-title":"Structural insights into the molecular mechanism of the m(6)A writer\ncomplex","volume":"5","author":"S\u0301ledz\u0301","year":"2016","journal-title":"eLife"},{"key":"2026102111064069700_cit10","doi-asserted-by":"crossref","unstructured":"Qi, S.; Kumar, A.; Chen, S.; Zhou, S.; Parihar, M.; Villalobos, C.; Gupta, N.; Chan, S.-H.; Rao, M. K.; McHardy, S. F.; Haider, S.; Gupta, Y. K.\n          Structure of METTL3-METTL14 with an m6A nucleotide\nreveals insights into m6A conversion and sensing. 2025.","DOI":"10.7554\/eLife.104909"},{"issue":"6225","key":"2026102111064069700_cit11","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1126\/science.1261417","article-title":"Stem cells. m6A\nmRNA methylation facilitates resolution of nai\u0308ve pluripotency\ntoward differentiation","volume":"347","author":"Geula","year":"2015","journal-title":"Science"},{"issue":"3","key":"2026102111064069700_cit12","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1021\/acs.jmedchem.2c01601","article-title":"METTL3 from\nTarget Validation to the First Small-Molecule Inhibitors: A Medicinal\nChemistry Journey","volume":"66","author":"Fiorentino","year":"2023","journal-title":"J. Med. Chem."},{"issue":"1","key":"2026102111064069700_cit13","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-03351-3","article-title":"The role and\nmechanism of METTL3 in cancer: emerging insights into m6A methylation\nand therapeutic potential","volume":"30","author":"Yuan","year":"2025","journal-title":"Eur. J. Med. Res."},{"issue":"2","key":"2026102111064069700_cit14","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/cr.2014.3","article-title":"Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine\nmethyltransferase","volume":"24","author":"Ping","year":"2014","journal-title":"Cell Res."},{"key":"2026102111064069700_cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-018-0019-0","article-title":"VIRMA mediates preferential\nm(6)A mRNA methylation in 3\u2032UTR and near stop codon and associates\nwith alternative polyadenylation","volume":"4","author":"Yue","year":"2018","journal-title":"Cell Discovery"},{"issue":"7620","key":"2026102111064069700_cit16","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nature19342","article-title":"m(6)A RNA\nmethylation promotes XIST-mediated\ntranscriptional repression","volume":"537","author":"Patil","year":"2016","journal-title":"Nature"},{"issue":"1","key":"2026102111064069700_cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23892-5","article-title":"Hakai is required for stabilization of core components\nof the m(6)A mRNA methylation machinery","volume":"12","author":"Bawankar","year":"2021","journal-title":"Nat.\nCommun."},{"issue":"6","key":"2026102111064069700_cit18","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.molcel.2018.02.015","article-title":"Zc3h13 Regulates\nNuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal","volume":"69","author":"Wen","year":"2018","journal-title":"Mol. Cell"},{"issue":"7683","key":"2026102111064069700_cit19","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/nature24678","article-title":"Promoter-bound METTL3 maintains myeloid leukaemia by\nm6A-dependent translation control","volume":"552","author":"Barbieri","year":"2017","journal-title":"Nature"},{"issue":"11","key":"2026102111064069700_cit20","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1038\/nm.4416","article-title":"The N(6)-methyladenosine\n(m(6)A)-forming enzyme METTL3 controls myeloid differentiation of\nnormal hematopoietic and leukemia cells","volume":"23","author":"Vu","year":"2017","journal-title":"Nat.\nMed."},{"key":"2026102111064069700_cit21","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41586-021-03536-w","article-title":"Small molecule\ninhibition of METTL3 as a strategy against myeloid leukaemia","volume":"593","author":"Yankova","year":"2021","journal-title":"Nature"},{"issue":"2","key":"2026102111064069700_cit22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.stem.2017.11.016","article-title":"METTL14 Inhibits\nHematopoietic Stem\/Progenitor Differentiation and Promotes Leukemogenesis\nvia mRNA m(6)A Modification","volume":"22","author":"Weng","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2026102111064069700_cit23","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.canlet.2017.11.018","article-title":"HBXIP-elevated methyltransferase\nMETTL3 promotes the progression\nof breast cancer via inhibiting tumor suppressor let-7g","volume":"415","author":"Cai","year":"2018","journal-title":"Cancer Lett."},{"key":"2026102111064069700_cit24","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75231","article-title":"METTL3 promotes homologous\nrecombination\nrepair and modulates chemotherapeutic response in breast cancer by\nregulating the EGF\/RAD51 axis","volume":"11","author":"Li","year":"2022","journal-title":"eLife"},{"key":"2026102111064069700_cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216846","article-title":"XBP1s activates\nMETTL3\/METTL14 for ER-phagy and paclitaxel sensitivity regulation\nin breast cancer","volume":"596","author":"Wang","year":"2024","journal-title":"Cancer Lett."},{"issue":"1","key":"2026102111064069700_cit26","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02581-1","article-title":"The N6-methyladenosine METTL3 regulates tumorigenesis\nand glycolysis by mediating m6A methylation of the tumor suppressor\nLATS1 in breast cancer","volume":"42","author":"Xu","year":"2023","journal-title":"J. Exp. Clin. Cancer\nRes."},{"issue":"1","key":"2026102111064069700_cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-025-00861-5","article-title":"Functional and clinical\nsignificance of the RNA m6A\nmethyltransferase complex in breast cancer","volume":"11","author":"Harris","year":"2025","journal-title":"npj Breast Cancer"},{"issue":"2","key":"2026102111064069700_cit28","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1002\/cac2.12509","article-title":"Enhancing sensitivity of triple-negative breast cancer\nto DNA-damaging therapy through chemical inhibition of the m6A methyltransferase\nMETTL3","volume":"44","author":"Cesaro","year":"2024","journal-title":"Cancer Commun."},{"issue":"24","key":"2026102111064069700_cit29","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202402611","article-title":"A Stapled\nPeptide Inhibitor Targeting the Binding Interface of N6-Adenosine-Methyltransferase\nSubunits METTL3 and METTL14 for Cancer Therapy","volume":"63","author":"Li","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"issue":"48","key":"2026102111064069700_cit30","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202407381","article-title":"Peptide Degrader-Based Targeting\nof METTL3\/14 Improves Immunotherapy Response in Cutaneous Melanoma","volume":"63","author":"Han","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"issue":"5","key":"2026102111064069700_cit31","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/nrm.2017.130","article-title":"A brave new world of\nRNA-binding proteins","volume":"19","author":"Hentze","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"2026102111064069700_cit32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.molcel.2020.03.011","article-title":"How RNA-Binding Proteins Interact\nwith RNA: Molecules and Mechanisms","volume":"78","author":"Corley","year":"2020","journal-title":"Mol. Cell"},{"issue":"3","key":"2026102111064069700_cit33","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41592-019-0330-1","article-title":"Methods to study RNA-protein interactions","volume":"16","author":"Ramanathan","year":"2019","journal-title":"Nat. Methods"},{"issue":"1","key":"2026102111064069700_cit34","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.str.2019.11.017","article-title":"Integrative\nStructural\nBiology of Protein-RNA Complexes","volume":"28","author":"Dimitrova-Paternoga","year":"2020","journal-title":"Structure"},{"key":"2026102111064069700_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2025.103137","article-title":"Modeling flexible RNA 3D structures and RNA-protein\ncomplexes","volume":"94","author":"Loureiro","year":"2025","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"4","key":"2026102111064069700_cit36","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1261\/rna.064063.117","article-title":"Interactions, localization,\nand phosphorylation of\nthe m(6)A generating METTL3-METTL14-WTAP complex","volume":"24","author":"Scho\u0308ller","year":"2018","journal-title":"RNA"},{"issue":"1","key":"2026102111064069700_cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-023-00604-5","article-title":"WTAP\u2013VIRMA\ncounteracts dsDNA binding of the m6A writer METTL3\u2013METTL14\ncomplex and maintains N6-adenosine methylation activity","volume":"9","author":"Yan","year":"2023","journal-title":"Cell Discovery"},{"issue":"5","key":"2026102111064069700_cit38","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020106309","article-title":"m(6) A deposition is regulated by PRMT1-mediated arginine\nmethylation of METTL14 in its disordered C-terminal region","volume":"40","author":"Wang","year":"2021","journal-title":"EMBO J."},{"issue":"1","key":"2026102111064069700_cit39","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1093\/nar\/gkab1211","article-title":"Recognition\nof G-quadruplex RNA by a crucial RNA methyltransferase component,\nMETTL14","volume":"50","author":"Yoshida","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2026102111064069700_cit40","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67150","article-title":"RNA binding\nto human METTL3-METTL14\nrestricts N(6)-deoxyadenosine methylation of DNA in vitro","volume":"11","author":"Qi","year":"2022","journal-title":"eLife"},{"key":"2026102111064069700_cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-019-0136-4","article-title":"Human MettL3-MettL14 complex is a\nsequence-specific DNA adenine methyltransferase active on single-strand\nand unpaired DNA in vitro","volume":"5","author":"Woodcock","year":"2019","journal-title":"Cell Discovery"},{"issue":"20","key":"2026102111064069700_cit42","doi-asserted-by":"publisher","first-page":"11629","DOI":"10.1093\/nar\/gkab460","article-title":"Human MettL3-MettL14 RNA adenine\nmethyltransferase complex is active on double-stranded DNA containing\nlesions","volume":"49","author":"Yu","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"2026102111064069700_cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2023.103548","article-title":"Native mass\nspectrometry-directed\ndrug discovery: Recent advances in investigating protein function\nand modulation","volume":"28","author":"Fiorentino","year":"2023","journal-title":"Drug Discovery Today"},{"issue":"5","key":"2026102111064069700_cit44","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1080\/17460441.2025.2486146","article-title":"Native mass\nspectrometry for proximity-inducing compounds: a new opportunity for\nstudying chemical-induced protein modulation","volume":"20","author":"Fabbrizi","year":"2025","journal-title":"Expert Opin. Drug Discovery"},{"issue":"11","key":"2026102111064069700_cit45","doi-asserted-by":"publisher","first-page":"5114","DOI":"10.1039\/D5MD00617A","article-title":"Toward routine utilisation\nof native mass spectrometry\nas an enabler of contemporary drug development","volume":"16","author":"Sternicki","year":"2025","journal-title":"RSC Med. Chem."},{"issue":"8","key":"2026102111064069700_cit46","doi-asserted-by":"publisher","first-page":"7327","DOI":"10.1021\/acs.chemrev.1c00293","article-title":"Protein\u2013Small\nMolecule Interactions\nin Native Mass Spectrometry","volume":"122","author":"Bennett","year":"2022","journal-title":"Chem. Rev."},{"issue":"8","key":"2026102111064069700_cit47","doi-asserted-by":"publisher","first-page":"7720","DOI":"10.1021\/acs.chemrev.1c00386","article-title":"Mass Spectrometry of Nucleic Acid\nNoncovalent Complexes","volume":"122","author":"Largy","year":"2022","journal-title":"Chem. 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