{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:49:14Z","timestamp":1792003754164,"version":"4.4.0"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci??n y Universidades","doi-asserted-by":"publisher","award":["PID2023-147939NB-I00"],"award-info":[{"award-number":["PID2023-147939NB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018694","name":"HORIZON EUROPE Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["101063551"],"award-info":[{"award-number":["101063551"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Commission","doi-asserted-by":"publisher","award":["ERC-2020-SyG-951231"],"award-info":[{"award-number":["ERC-2020-SyG-951231"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Commission","doi-asserted-by":"publisher","award":["ERC-2024-StG-290836"],"award-info":[{"award-number":["ERC-2024-StG-290836"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Commission","doi-asserted-by":"publisher","award":["PID2023-147939NB-I00"],"award-info":[{"award-number":["PID2023-147939NB-I00"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Ministerio de Econom??a y Competitividad","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neutral glucosylceramidase GBA2 is a retaining \u03b2-d-glucosidase involved in sphingolipid metabolism and implicated in neurological lysosomal storage disorders, yet the lack of highly selective chemical inhibitors has hindered efforts to disentangle its function from that of glucosylceramide synthase (GCS) and lysosomal glucosylceramidase (GBA1). Here, we report the development of the first brain-penetrant, covalent inhibitor that selectively inactivates GBA2 in vivo. Building on \u03b2-d-arabinofuranose-configured (\u03b2-d-Araf) cyclitol aziridine activity-based probes previously shown to covalently and selectively label GBA2, we designed and synthesized a focused library of electrophile-bearing cyclitols, including epoxides, cyclic sulfates, and a diverse set of N-alkyl aziridines. Biochemical evaluation of their inhibitory activity against GBA1, GBA2, GBA3 and GCS revealed that several N-alkyl aziridines are highly selective, nanomolar GBA2 inhibitors. Lead compounds also demonstrated metabolic stability in murine plasma, robust cellular activity and high selectivity in living cells, with no detectable GCS inhibition. Notably, octyl-alkyne aziridine 5 selectively inhibited GBA2 in mouse brain, representing the first covalent GBA2 inhibitor with demonstrated in vivo activity and brain permeability. Together, these results establish \u03b2-d-Araf cyclitol aziridine 5 as a versatile inhibitor for selective, covalent GBA2 inhibition, well suited to dissect GBA2 biology in vivo, particularly in neurological lysosomal storage disorders.<\/jats:p>","DOI":"10.1021\/jacs.6c09754","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:02:49Z","timestamp":1790672569000},"page":"43072-43080","source":"Crossref","is-referenced-by-count":0,"title":["\u03b2-\n                    <scp>d<\/scp>\n                    -Arabinofuranose-configured\nCyclitol Aziridines as Selective, Brain-penetrant Covalent GBA2 Inhibitors"],"prefix":"10.1021","volume":"148","author":[{"given":"Rob F.","family":"Lammers","sequence":"first","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Su","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mazo","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona , , Marti\u0301 i Franque\u0300s 1 , ,","place":["Barcelona, Spain, 08028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-4531","authenticated-orcid":true,"given":"Wendy","family":"A. Offen","sequence":"additional","affiliation":[{"name":"University of York , , Heslington , ,","place":["York, U.K., YO10 5DD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roelof","family":"Ottenhoff","sequence":"additional","affiliation":[{"name":"University of Amsterdam , , ,","place":["Amsterdam, The Netherlands, 1105AZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats J.","family":"Bulterman","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"van der Lienden","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Ferraz","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0671-1546","authenticated-orcid":true,"given":"Florian","family":"Ku\u0308llmer","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahid","family":"Ilhan","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"van den Elst","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"van der Made","sequence":"additional","affiliation":[{"name":"University of Amsterdam , , ,","place":["Amsterdam, The Netherlands, 1105AZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy P. A. A.","family":"van Roomen","sequence":"additional","affiliation":[{"name":"University of Amsterdam , , ,","place":["Amsterdam, The Netherlands, 1105AZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"de Jongh","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianus M. C. H.","family":"van den Nieuwendijk","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf G.","family":"Boot","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-7532","authenticated-orcid":true,"given":"Noam","family":"Zelcer","sequence":"additional","affiliation":[{"name":"University of Amsterdam , , ,","place":["Amsterdam, The Netherlands, 1105AZ"]},{"name":"Amsterdam University Medical Center , , ,","place":["Amsterdam, The Netherlands, 1105AZ"]},{"name":"Amsterdam University Medical Center , , ,","place":["Amsterdam, The Netherlands, 1105AZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7343-776X","authenticated-orcid":true,"given":"Gideon J.","family":"Davies","sequence":"additional","affiliation":[{"name":"University of York , , Heslington , ,","place":["York, U.K., YO10 5DD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1477-5010","authenticated-orcid":true,"given":"Carme","family":"Rovira","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona , , Marti\u0301 i Franque\u0300s 1 , ,","place":["Barcelona, Spain, 08028"]},{"name":"Fundacio\u0301 Catalana de Recerca i Estudis Avanc\u0327ats (ICREA), Passeig Llui\u0301s Companys 23 , ,","place":["Barcelona, Spain, 08010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6976-7005","authenticated-orcid":true,"given":"Herman S.","family":"Overkleeft","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-2565","authenticated-orcid":true,"given":"Johannes M. F. G.","family":"Aerts","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3051-3902","authenticated-orcid":true,"given":"Marta","family":"Artola","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry and Bio-organic Synthesis, Leiden Institute of Chemistry (LIC), Leiden University , P.O. Box 9502, ,","place":["RA Leiden, The Netherlands, 2300"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"2026101414071501600_cit1","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1074\/jbc.M610544200","article-title":"Identification\nof the non-lysosomal glucosylceramidase as \u03b2-glucosidase 2","volume":"282","author":"Boot","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2026101414071501600_cit2","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1074\/jbc.M112.414714","article-title":"The non-lysosomal \u03b2-glucosidase GBA2 is a non-integral\nmembrane-associated protein at the endoplasmic reticulum (ER) and\nGolgi","volume":"288","author":"Ko\u0308rschen","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2026101414071501600_cit3","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1172\/JCI29224","article-title":"Mutation of \u03b2-glucosidase 2 causes glycolipid\nstorage disease and impaired male fertility","volume":"116","author":"Yildiz","year":"2006","journal-title":"J. Clin. Investig."},{"key":"2026101414071501600_cit4","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.neuron.2017.01.018","article-title":"The complicated relationship between\nGaucher disease and parkinsonism: Insights from a rare disease","volume":"93","author":"Aflaki","year":"2017","journal-title":"Neuron"},{"key":"2026101414071501600_cit5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13024-019-0336-2","article-title":"Glucocerebrosidase\nand its relevance to Parkinson disease","volume":"14","author":"Do","year":"2019","journal-title":"Mol.\nNeurodegener."},{"key":"2026101414071501600_cit6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/1750-1172-8-151","article-title":"Functional\nand genetic characterization\nof the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher\ndisease","volume":"8","author":"Yildiz","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"key":"2026101414071501600_cit7","doi-asserted-by":"publisher","first-page":"35351","DOI":"10.1074\/jbc.M114.593376","article-title":"A sensitive gel-based method combining distinct cyclophellitol-based\nprobes for the identification of acid\/base residues in human retaining\n\u03b2-glucosidases","volume":"289","author":"Kallemeijn","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2026101414071501600_cit8","doi-asserted-by":"publisher","first-page":"14192","DOI":"10.1021\/jacs.7b07352","article-title":"A fluorescence polarization activity-based\nprotein profiling assay in the discovery of potent, selective inhibitors\nfor human nonlysosomal glucosylceramidase","volume":"139","author":"Lahav","year":"2017","journal-title":"J.\nAm. Chem. Soc."},{"key":"2026101414071501600_cit9","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1098\/rstb.2003.1278","article-title":"Small\u2013molecule\ntherapeutics for the treatment of glycolipid lysosomal storage disorders","volume":"358","author":"Butters","year":"2003","journal-title":"Philos. Trans. R. Soc. B, Biol. Sci."},{"key":"2026101414071501600_cit10","doi-asserted-by":"publisher","first-page":"113175","DOI":"10.1016\/j.yexcr.2022.113175","article-title":"Cytokine profile\nand cholesterol levels in patients with Niemann-Pick type C disease\npresenting neurological symptoms: In vivo effect of miglustat and\nin vitro effect of N-acetylcysteine and coenzyme q10","volume":"416","author":"Hammerschmidt","year":"2022","journal-title":"Exp. Cell Res."},{"key":"2026101414071501600_cit11","doi-asserted-by":"publisher","first-page":"877","DOI":"10.2147\/TCRM.S5777","article-title":"New therapies in the\nmanagement of Niemann-Pick type C disease: Clinical\nutility of miglustat","volume":"5","author":"Wraith","year":"2009","journal-title":"Ther. Clin. Risk Manage."},{"key":"2026101414071501600_cit12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135889","article-title":"Reducing\nGBA2 activity ameliorates neuropathology in Niemann-Pick type C mice","volume":"10","author":"Marques","year":"2015","journal-title":"PLoS One"},{"key":"2026101414071501600_cit13","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.ymgme.2012.01.020","article-title":"Iminosugar-based\ninhibitors of glucosylceramide synthase prolong survival but paradoxically\nincrease brain glucosylceramide levels in Niemann\u2013Pick C mice","volume":"105","author":"Nietupski","year":"2012","journal-title":"Mol. Genet. Metab."},{"key":"2026101414071501600_cit14","doi-asserted-by":"publisher","first-page":"4934","DOI":"10.1073\/pnas.1400768111","article-title":"Glucocerebrosidase 2 gene deletion\nrescues type 1 Gaucher disease","volume":"111","author":"Mistry","year":"2014","journal-title":"Proc. Natl.\nAcad. Sci. U.S.A."},{"key":"2026101414071501600_cit15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021758","article-title":"Iminosugar-based inhibitors\nof glucosylceramide synthase\nincrease brain glycosphingolipids and survival in a mouse model of\nSandhoff disease","volume":"6","author":"Ashe","year":"2011","journal-title":"PLoS One"},{"key":"2026101414071501600_cit16","doi-asserted-by":"publisher","first-page":"15212","DOI":"10.1039\/D3SC06146A","article-title":"Selective labelling of GBA2 in cells\nwith fluorescent \u03b2-D-arabinofuranosyl cyclitol aziridines","volume":"15","author":"Su","year":"2024","journal-title":"Chem. Sci."},{"key":"2026101414071501600_cit17","doi-asserted-by":"publisher","first-page":"26522","DOI":"10.1074\/jbc.273.41.26522","article-title":"Generation\nof specific deoxynojirimycin-type inhibitors\nof the non-lysosomal glucosylceramidase","volume":"273","author":"Overkleeft","year":"1998","journal-title":"J.\nBiol. Chem."},{"key":"2026101414071501600_cit18","doi-asserted-by":"publisher","first-page":"9096","DOI":"10.1021\/jm501181z","article-title":"Identification\nand development of biphenyl substituted iminosugars as improved dual\nglucosylceramide synthase\/neutral glucosylceramidase inhibitors","volume":"57","author":"Ghisaidoobe","year":"2014","journal-title":"J. Med. Chem."},{"key":"2026101414071501600_cit19","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1039\/b210038j","article-title":"Aziridines as a structural motif\nto conformational restriction of\nazasugars","volume":"1","author":"Lopez","year":"2003","journal-title":"Org. Biomol. Chem."},{"key":"2026101414071501600_cit20","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1039\/p19790001455","article-title":"Unsaturated\ncarbohydrates. Part 21. A carbocyclic ring closure of a hex-5-enopyranoside\nderivative","volume":"1","author":"Ferrier","year":"1979","journal-title":"J. Chem. Soc., Perkin Trans."},{"key":"2026101414071501600_cit21","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1039\/b804784g","article-title":"A convenient\nsynthesis of orthogonally protected 2-deoxystreptamine (2-dos) as\nan aminocyclitol scaffold for the development of novel aminoglycoside\nantibiotic derivatives against bacterial resistance","volume":"6","author":"Bauder","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"2026101414071501600_cit22","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1002\/hlca.19790620736","article-title":"Carbocyclische Verbindungen\naus Monosacchariden. II.\nUmsetzungen in der Mannosereihe","volume":"62","author":"Bernet","year":"1979","journal-title":"Helv. Chim.\nActa"},{"key":"2026101414071501600_cit23","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1002\/hlca.19790620737","article-title":"Carbocyclen aus Monosacchariden.\nIII. Zur Diastereoselektivita\u0308t\nder Bildung von Cyclopentanderivaten. Umsetzungen in der Galactosereihe","volume":"62","author":"Bernet","year":"1979","journal-title":"Helv. Chim. Acta"},{"key":"2026101414071501600_cit24","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1039\/c39810000983","article-title":"A general route to optically pure prostaglandins from\na D-glucose derivative","author":"Ferrier","year":"1981","journal-title":"J. Chem. Soc., Chem.\nCommun."},{"key":"2026101414071501600_cit25","doi-asserted-by":"publisher","first-page":"4648","DOI":"10.1021\/jacs.9b11351","article-title":"Rational design of mechanism-based inhibitors and activity-based\nprobes for the identification of retaining \u03b1-l-arabinofuranosidases","volume":"142","author":"McGregor","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"2026101414071501600_cit26","doi-asserted-by":"publisher","first-page":"12528","DOI":"10.1039\/C7CC07730K","article-title":"Towards broad spectrum activity-based glycosidase probes:\nSynthesis and evaluation of deoxygenated cyclophellitol aziridines","volume":"53","author":"Schro\u0308der","year":"2017","journal-title":"Chem. Commun."},{"key":"2026101414071501600_cit27","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.1002\/cbic.202100396","article-title":"Xylose-configured\ncyclophellitols\nas selective inhibitors for glucocerebrosidase","volume":"22","author":"Su","year":"2021","journal-title":"ChemBioChem"},{"key":"2026101414071501600_cit28","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1074\/jbc.RA118.006311","article-title":"Species-specific\ndifferences in nonlysosomal glucosylceramidase GBA2 function underlie\nlocomotor dysfunction arising from loss-of-function mutations","volume":"294","author":"Woeste","year":"2019","journal-title":"J. Biol. Chem."},{"key":"2026101414071501600_cit29","doi-asserted-by":"publisher","first-page":"12529","DOI":"10.1002\/anie.201207771","article-title":"Novel activity-based probes for broad-spectrum profiling\nof retaining \u03b2-exoglucosidases in situ and in vivo","volume":"51","author":"Kallemeijn","year":"2012","journal-title":"Angew. Chem., Int. Ed."}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c09754","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/40\/43072\/68685669\/jacs.6c09754.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/40\/43072\/68685669\/jacs.6c09754.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:17:02Z","timestamp":1792001822000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/40\/43072\/5440470\/d-Arabinofuranose-configured-Cyclitol-Aziridines"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":29,"journal-issue":{"issue":"40","published-online":{"date-parts":[[2026,9,29]]},"published-print":{"date-parts":[[2026,10,14]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c09754","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]}}}