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This strategy effectively converts these carbonyl compounds into dianion equivalents to undergo deoxygenative gem-difunctionalization with various electrophiles. Faradaic control was achieved over reaction chemoselectivity, allowing for the combinatorial construction of densely functionalized silanes, boronates, and germanes.<\/jats:p>","DOI":"10.1021\/jacs.6c09867","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T17:02:13Z","timestamp":1786381333000},"page":"34058-34065","source":"Crossref","is-referenced-by-count":0,"title":["Geminal Difunctionalizations\nof Aliphatic Ketones\nand Aldehydes Enabled by Thioacetal Activation and Deep Electroreduction"],"prefix":"10.1021","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9438-5172","authenticated-orcid":true,"given":"Nicholas I.","family":"Cemalovic","sequence":"first","affiliation":[{"name":"Cornell University , , , ,","place":["Ithaca, New York, United States, 14853"]},{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8304-3360","authenticated-orcid":true,"given":"Andrew J.","family":"Ressler","sequence":"additional","affiliation":[{"name":"Cornell University , , , ,","place":["Ithaca, New York, United States, 14853"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchira S.","family":"Hariharan","sequence":"additional","affiliation":[{"name":"Cornell University , , , ,","place":["Ithaca, New York, United States, 14853"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-1823","authenticated-orcid":true,"given":"Samantha N.","family":"MacMillan","sequence":"additional","affiliation":[{"name":"Cornell University , , , ,","place":["Ithaca, New York, United States, 14853"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8880-6476","authenticated-orcid":true,"given":"Song","family":"Lin","sequence":"additional","affiliation":[{"name":"Cornell University , , , ,","place":["Ithaca, New York, United States, 14853"]},{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"2026081910220478500_cit1a","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1021\/acs.jnatprod.8b01022","article-title":"A Systematic\nCheminformatics Analysis of Functional Groups Occurring in Natural\nProducts","volume":"82","author":"Ertl","year":"2019","journal-title":"J. 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