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In this work, through the cooperation of multiple catalysts, we realized a dedioxygenative phosphonylation of carboxylic acids that is applicable to both aliphatic and aromatic substrates, showing good scope and functional-group tolerance. This protocol also demonstrates promising performance in the late-stage modification of complex molecules. Meanwhile, it establishes a formal deoxygenative coupling approach that enables rapid access to alkenes from carboxylic acids and aldehydes or alcohols. Mechanistic studies reveal distinct activation modes for different C\u2013O bonds and further highlight a carbon-retentive transformation pattern of carboxylic acids, complementing conventional carbon-deletion decarboxylative phosphonylation based on redox-active esters or other strategies.<\/jats:p>","DOI":"10.1021\/jacs.6c09874","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:54:13Z","timestamp":1784163253000},"page":"31577-31584","source":"Crossref","is-referenced-by-count":2,"title":["Dedioxygenative\nPhosphonylation of Carboxylic Acids"],"prefix":"10.1021","volume":"148","author":[{"given":"Xiaoqiang","family":"Wu","sequence":"first","affiliation":[{"name":"Tongji University , , 1239 Siping Road , ,","place":["Shanghai, P. R. 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