{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:02:04Z","timestamp":1790485324317,"version":"4.1.0"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020770","name":"Research Institute Centers, New York University Abu Dhabi","doi-asserted-by":"publisher","award":["ADHPG-CGSB"],"award-info":[{"award-number":["ADHPG-CGSB"]}],"id":[{"id":"10.13039\/100020770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f?r Infektionsforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012025","name":"New York University Abu Dhabi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Research Council (DFG)","award":["GRK2873 - 494832089"],"award-info":[{"award-number":["GRK2873 - 494832089"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["32470066"],"award-info":[{"award-number":["32470066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gram-negative bacteria present a major clinical challenge but also remain an underexplored source of antibacterial natural products. Resistance-guided genome mining of the entomopathogenic symbiont Xenorhabdus identified the rdb biosynthetic gene cluster, which encodes a putative prodrug antibiotic, pre-rhabdobranin. However, the inability to isolate the proposed active metabolite, rhabdobranin, has prevented direct functional evaluation. Here we report a convergent total synthesis of the proposed structure of pre-rhabdobranin B, which revealed a stereochemical misassignment at the N-terminal arginine residue. Synthesis of both rhabdobranin epimers showed that, although they are nearly indistinguishable by standard analytical methods, inversion at this single stereocenter has a pronounced effect on antibacterial activity. Biological evaluation of the revised rhabdobranin structure revealed potent antibacterial activity against Gram-negative pathogens, including WHO critical-priority carbapenem-resistant Klebsiella pneumoniae. Cellular and biochemical profiling implicated inhibition of protein biosynthesis as its principal antibacterial mechanism. We further show that the GNAT-family acetyltransferase RdbK N-acetylates rhabdobranin, attenuating its activity and establishing a secondary self-resistance mechanism. These findings validate resistance-gene-guided discovery in Gram-negative symbionts as a strategy for uncovering cryptic antibiotics and identify rhabdobranin as a promising scaffold for Gram-negative antibiotic development.<\/jats:p>","DOI":"10.1021\/jacs.6c09931","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:51:29Z","timestamp":1788303089000},"page":"38069-38079","source":"Crossref","is-referenced-by-count":1,"title":["Total Synthesis and\nStructural Revision of Rhabdobranin\nReveals a Cryptic Gram-Negative Antibiotic"],"prefix":"10.1021","volume":"148","author":[{"given":"Woonkee S.","family":"Jo","sequence":"first","affiliation":[{"name":"New York University Abu Dhabi , , Saadiyat Island , ,","place":["Abu Dhabi, United Arab Emirates (UAE), 129188"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaynoun","family":"Attieh","sequence":"additional","affiliation":[{"name":"New York University Abu Dhabi , , Saadiyat Island , ,","place":["Abu Dhabi, UAE, 129188"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Johannes","family":"Crames","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Terrestrial Microbiology , , ,","place":["Marburg, Germany, 35043"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl Leonhard","family":"Knopp","sequence":"additional","affiliation":[{"name":"University Hospital Bonn, University of Bonn , , ,","place":["Bonn, Germany, 53113"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Connelly","sequence":"additional","affiliation":[{"name":"New York University Abu Dhabi , , Saadiyat Island , ,","place":["Abu Dhabi, UAE, 129188"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6933-4971","authenticated-orcid":true,"given":"Yi-Ming","family":"Shi","sequence":"additional","affiliation":[{"name":"Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , , ,","place":["Shenzhen, China, 518055"]},{"name":"Max Planck-Chinese Academy of Sciences Center for Synthetic Biochemistry , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Terrestrial Microbiology , , ,","place":["Marburg, Germany, 35043"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4387-4368","authenticated-orcid":true,"given":"Maryam","family":"Dehghan","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Terrestrial Microbiology , , ,","place":["Marburg, Germany, 35043"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gru\u0308n","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Terrestrial Microbiology , , ,","place":["Marburg, Germany, 35043"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunna","family":"Chang","sequence":"additional","affiliation":[{"name":"New York University Abu Dhabi , , Saadiyat Island , ,","place":["Abu Dhabi, United Arab Emirates (UAE), 129188"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fathima S.","family":"Refai","sequence":"additional","affiliation":[{"name":"New York University Abu Dhabi , , Saadiyat Island , ,","place":["Abu Dhabi, UAE, 129188"]},{"name":"Universita\u0300 di Udine , , ,","place":["Udine, Italy, 33100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Piano","sequence":"additional","affiliation":[{"name":"New York University Abu Dhabi , , Saadiyat Island , ,","place":["Abu Dhabi, UAE, 129188"]},{"name":"New York University , , , ,","place":["New York, New York, United States, 10003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin C.","family":"Gunsalus","sequence":"additional","affiliation":[{"name":"New York University Abu Dhabi , , Saadiyat Island , ,","place":["Abu Dhabi, UAE, 129188"]},{"name":"New York University Abu Dhabi , , Saadiyat Island , ,","place":["Abu Dhabi, UAE, 129188"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Schneider","sequence":"additional","affiliation":[{"name":"University Hospital Bonn, University of Bonn , , ,","place":["Bonn, Germany, 53113"]},{"name":"DZIF, German Center for Infectious Research , Partner Site Bonn-Cologne , ,","place":["Bonn, Germany, 53113"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge B.","family":"Bode","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Terrestrial Microbiology , , ,","place":["Marburg, Germany, 35043"]},{"name":"Philipps University Marburg , , ,","place":["Marburg, Germany, 35043"]},{"name":"Philipps University Marburg , , ,","place":["Marburg, Germany, 35043"]},{"name":"Max Planck-Chinese Academy of Sciences Center for Synthetic Bichemistry , ,","place":["Marburg, Germany, 35043"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1231-8353","authenticated-orcid":true,"given":"Alan R.","family":"Healy","sequence":"additional","affiliation":[{"name":"New York University Abu Dhabi , , Saadiyat Island , ,","place":["Abu Dhabi, United Arab Emirates (UAE), 129188"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"2026090910092832100_cit1","unstructured":"O\u2019Neill, J.\n          \n          Antimicrobial\nresistance: tackling a crisis for the health and wealth of nations; Review on Antimicrobial Resistance2014."},{"key":"2026090910092832100_cit2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3389\/fpubh.2014.00145","article-title":"The Antimicrobial Resistance Crisis:\nCauses, Consequences, and Management","volume":"2","author":"Michael","year":"2014","journal-title":"Front.\nPublic Health"},{"issue":"10459","key":"2026090910092832100_cit3","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/S0140-6736(24)01867-1","article-title":"Global\nburden of bacterial antimicrobial resistance 1990\u20132021: a systematic\nanalysis with forecasts to 2050","volume":"404","author":"Naghavi","year":"2024","journal-title":"Lancet"},{"issue":"9","key":"2026090910092832100_cit4","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S1473-3099(25)00118-5","article-title":"The WHO Bacterial Priority\nPathogens List 2024: a prioritisation study to guide research, development,\nand public health strategies against antimicrobial resistance","volume":"25","author":"Sati","year":"2025","journal-title":"Lancet Infect. Dis."},{"issue":"10474","key":"2026090910092832100_cit5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0140-6736(24)02081-6","article-title":"Multidrug-resistant\nGram-negative\nbacterial infections","volume":"405","author":"Macesic","year":"2025","journal-title":"Lancet"},{"issue":"9","key":"2026090910092832100_cit6","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1039\/C9NP00020H","article-title":"Marine\nProteobacteria\nas a source of natural products: advances in molecular tools and strategies","volume":"36","author":"Buijs","year":"2019","journal-title":"Nat. Prod. Rep."},{"issue":"6","key":"2026090910092832100_cit7","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1039\/D3NP00062A","article-title":"Recent advances\nin discovery and biosynthesis of natural products from myxobacteria:\nan overview from 2017 to 2023","volume":"41","author":"Wang","year":"2024","journal-title":"Nat. Prod. Rep."},{"issue":"4","key":"2026090910092832100_cit8","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1039\/C7NP00054E","article-title":"Chemical language\nand warfare of bacterial natural\nproducts in bacteria\u2013nematode\u2013insect interactions","volume":"35","author":"Shi","year":"2018","journal-title":"Nat. Prod. Rep."},{"issue":"11","key":"2026090910092832100_cit9","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.70032","article-title":"Harnessing\nGram-negative bacteria for novel anti-Gram-negative antibiotics","volume":"17","author":"Birkelbach","year":"2024","journal-title":"Microb. Biotechnol."},{"issue":"7","key":"2026090910092832100_cit10","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1039\/C7NP00010C","article-title":"Antibiotics from Gram-negative bacteria:\na comprehensive overview and selected biosynthetic highlights","volume":"34","author":"Masschelein","year":"2017","journal-title":"Nat. Prod. Rep."},{"issue":"1","key":"2026090910092832100_cit11","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cell.2020.02.056","article-title":"The science\nof antibiotic discovery","volume":"181","author":"Lewis","year":"2020","journal-title":"Cell"},{"issue":"10","key":"2026090910092832100_cit12","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s41579-020-0379-y","article-title":"Ecology\nand genomics of Actinobacteria: new concepts for natural product discovery","volume":"18","author":"van Bergeijk","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"issue":"10","key":"2026090910092832100_cit13","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1039\/C7NP00026J","article-title":"Actinomycetes:\nstill a source of novel antibiotics","volume":"34","author":"Genilloud","year":"2017","journal-title":"Nat. Prod.\nRep."},{"key":"2026090910092832100_cit14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mib.2020.03.007","article-title":"Applying microbial\necology to antimicrobial discovery","volume":"57","author":"Pishchany","year":"2020","journal-title":"Curr. Opin.\nMicrobiol."},{"issue":"12","key":"2026090910092832100_cit15","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1038\/s41564-017-0039-9","article-title":"Natural\nproduct diversity\nassociated with the nematode symbionts Photorhabdus and Xenorhabdus","volume":"2","author":"Tobias","year":"2017","journal-title":"Nat. Microbiol."},{"issue":"10","key":"2026090910092832100_cit16","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.tim.2018.04.007","article-title":"Refining\nthe Natural Product Repertoire\nin Entomopathogenic Bacteria","volume":"26","author":"Tobias","year":"2018","journal-title":"Trends Microbiol."},{"issue":"12","key":"2026090910092832100_cit17","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/nchembio.688","article-title":"A natural prodrug activation mechanism\nin nonribosomal\npeptide synthesis","volume":"7","author":"Reimer","year":"2011","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"2026090910092832100_cit18","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1111\/j.1365-2958.2009.06817.x","article-title":"Genetic analysis of xenocoumacin\nantibiotic production in the mutualistic bacterium Xenorhabdus nematophila","volume":"73","author":"Park","year":"2009","journal-title":"Mol. Microbiol."},{"issue":"7","key":"2026090910092832100_cit19","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3390\/molecules21070824","article-title":"Activating and Attenuating\nthe Amicoumacin Antibiotics","volume":"21","author":"Park","year":"2016","journal-title":"Molecules"},{"issue":"1","key":"2026090910092832100_cit20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.molcel.2018.03.001","article-title":"Odilorhabdins,\nantibacterial agents that cause miscoding\nby binding at a new ribosomal site","volume":"70","author":"Pantel","year":"2018","journal-title":"Mol. Cell"},{"issue":"7787","key":"2026090910092832100_cit21","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/s41586-019-1791-1","article-title":"A new antibiotic selectively\nkills Gram-negative pathogens","volume":"576","author":"Imai","year":"2019","journal-title":"Nature"},{"issue":"10","key":"2026090910092832100_cit22","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1038\/s41564-022-01227-4","article-title":"Computational identification of a systemic\nantibiotic for gram-negative bacteria","volume":"7","author":"Miller","year":"2022","journal-title":"Nat.\nMicrobiol."},{"issue":"6","key":"2026090910092832100_cit23","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41557-022-00923-2","article-title":"Global analysis of biosynthetic gene clusters\nreveals conserved and unique natural products in entomopathogenic\nnematode-symbiotic bacteria","volume":"14","author":"Shi","year":"2022","journal-title":"Nat. Chem."},{"issue":"2","key":"2026090910092832100_cit24","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s10295-013-1356-5","article-title":"Merging\nchemical ecology with bacterial genome mining\nfor secondary metabolite discovery","volume":"41","author":"Vizcaino","year":"2014","journal-title":"J. Ind.\nMicrobiol. Biotechnol."},{"issue":"1","key":"2026090910092832100_cit25","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1038\/s41467-021-24133-5","article-title":"Mining and unearthing hidden biosynthetic\npotential","volume":"12","author":"Scherlach","year":"2021","journal-title":"Nat. Commun."},{"issue":"11","key":"2026090910092832100_cit26","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1039\/D1NP00032B","article-title":"Genome\nmining methods\nto discover bioactive natural products","volume":"38","author":"Bauman","year":"2021","journal-title":"Nat.\nProd. Rep."},{"issue":"W1","key":"2026090910092832100_cit27","doi-asserted-by":"publisher","first-page":"W546","DOI":"10.1093\/nar\/gkaa374","article-title":"ARTS 2.0:\nfeature updates and expansion of the Antibiotic\nResistant Target Seeker for comparative genome mining","volume":"48","author":"Mungan","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"2026090910092832100_cit28","doi-asserted-by":"publisher","first-page":"D736","DOI":"10.1093\/nar\/gkab940","article-title":"ARTS-DB: a database for antibiotic\nresistant targets","volume":"50","author":"Mungan","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"2026090910092832100_cit29","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/nbt.2685","article-title":"Identifying\nproducers\nof antibacterial compounds by screening for antibiotic resistance","volume":"31","author":"Thaker","year":"2013","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"2026090910092832100_cit30","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1021\/acschembio.8b00173","article-title":"Self-Resistance of Natural Product\nProducers: Past, Present, and Future Focusing on Self-Resistant Protein\nVariants","volume":"13","author":"Almabruk","year":"2018","journal-title":"ACS Chem. Biol."},{"issue":"9","key":"2026090910092832100_cit31","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.1128\/AAC.00111-11","article-title":"Validation of the Intact\nZwittermicin A Biosynthetic Gene Cluster\nand Discovery of a Complementary Resistance Mechanism in Bacillus\nthuringiensis","volume":"55","author":"Luo","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"2026090910092832100_cit32","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41589-022-01142-z","article-title":"Structural basis of\ncolibactin activation by the ClbP\npeptidase","volume":"19","author":"Velilla","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"2026090910092832100_cit33","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.biochi.2022.07.019","article-title":"Structure\nand function of prodrug-activating\npeptidases","volume":"205","author":"Velilla","year":"2023","journal-title":"Biochimie"},{"issue":"2","key":"2026090910092832100_cit34","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1039\/C3NP70081J","article-title":"A natural prodrug activation mechanism\nin the biosynthesis\nof nonribosomal peptides","volume":"31","author":"Reimer","year":"2014","journal-title":"Nat. Prod. Rep."},{"issue":"1","key":"2026090910092832100_cit35","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02826-21","article-title":"The odilorhabdin antibiotic biosynthetic cluster\nand acetyltransferase self-resistance locus are niche and species\nspecific","volume":"13","author":"Lanois-Nouri","year":"2022","journal-title":"mBio"},{"issue":"42","key":"2026090910092832100_cit36","doi-asserted-by":"publisher","first-page":"14817","DOI":"10.1021\/jacs.7b07807","article-title":"Molecular Basis of Gut Microbiome-Associated Colorectal\nCancer: A Synthetic Perspective","volume":"139","author":"Healy","year":"2017","journal-title":"J. Am. Chem.\nSoc."},{"issue":"2","key":"2026090910092832100_cit37","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1039\/B815077J","article-title":"Solid-phase synthesis of cyclic peptide Chitinase inhibitors:\nSAR of the argifin scaffold","volume":"7","author":"Dixon","year":"2009","journal-title":"Org. Biomol. Chem."},{"issue":"21","key":"2026090910092832100_cit38","doi-asserted-by":"publisher","first-page":"10929","DOI":"10.1039\/D4GC03209H","article-title":"Solid phase\npeptide synthesis using side-chain unprotected arginine and histidine\nwith Oxyma Pure\/TBEC in green solvents","volume":"26","author":"Fantoni","year":"2024","journal-title":"Green\nChem."},{"issue":"7","key":"2026090910092832100_cit39","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1039\/D1NP00069A","article-title":"Biosynthesis of quinolizidine alkaloids\nin lupins: mechanistic considerations and prospects for pathway elucidation","volume":"39","author":"Mancinotti","year":"2022","journal-title":"Nat. Prod. Rep."},{"key":"2026090910092832100_cit40","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv.15002531\/v1","volume-title":"Synthesis of (+)-Neopeltolide via\nSequence-Guided Iterative Assembly","author":"Namitharan","year":"2026"},{"issue":"10","key":"2026090910092832100_cit41","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1055\/s-2006-926465","article-title":"In situ\nGeneration and Nucleophilic\nCapture of 1,n-Dial Equivalents from 1,n-Dioates (\u03b1,\u03c9-Diesters)","volume":"2006","author":"Hoye","year":"2006","journal-title":"Synthesis"},{"issue":"11","key":"2026090910092832100_cit42","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/S0040-4039(00)84232-X","article-title":"An improved procedure for the two\ncarbon homologation of esters to \u03b1, \u03b2-unsaturated esters","volume":"27","author":"Takacs","year":"1986","journal-title":"Tetrahedron Lett."},{"issue":"08","key":"2026090910092832100_cit43","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1055\/s-2004-825626","article-title":"An improved procedure for asymmetric\naldol additions with N-acyl oxazolidinones, oxazolidinethiones\nand thiazolidinethiones","author":"Crimmins","year":"2004","journal-title":"Synlett"},{"issue":"11","key":"2026090910092832100_cit44","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1021\/np000160o","article-title":"Synthesis\nof the Marine Natural Product N\u03b1-(4-Bromopyrrolyl-2-carbonyl)-L-homoarginine,\na Putative Biogenetic Precursor of the Pyrrole\u2013Imidazole Alkaloids","volume":"63","author":"Lindel","year":"2000","journal-title":"J. Nat. Prod."},{"issue":"12","key":"2026090910092832100_cit45","doi-asserted-by":"publisher","first-page":"4490","DOI":"10.1021\/acs.orglett.9b01345","article-title":"Activity-Based Probe for Screening of High-Colibactin\nProducers from Clinical Samples","volume":"21","author":"Hirayama","year":"2019","journal-title":"Org. Lett."},{"issue":"2","key":"2026090910092832100_cit46","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0968-0896(96)00236-2","article-title":"Synthesis of novel\n6-amido-6-deoxy-l-galactose derivatives\nas sialyl Lewis X mimetics","volume":"5","author":"Cappi","year":"1997","journal-title":"Bioorg. Med. Chem."},{"issue":"21","key":"2026090910092832100_cit47","doi-asserted-by":"publisher","first-page":"9195","DOI":"10.1021\/jm3008823","article-title":"Structure-Based Design\nof Highly Selective \u03b2-Secretase Inhibitors: Synthesis, Biological\nEvaluation, and Protein\u2013Ligand X-ray Crystal Structure","volume":"55","author":"Ghosh","year":"2012","journal-title":"J. Med. Chem."},{"issue":"1","key":"2026090910092832100_cit48","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1021\/jacs.1c09616","article-title":"Total Synthesis and Biological Evaluation of Paenilamicins\nfrom the Honey Bee Pathogen Paenibacillus larvae","volume":"144","author":"Bulatov","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"18","key":"2026090910092832100_cit49","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202500124","article-title":"Total Synthesis\nof the Marine Diterpenoids Caucanolide E and F by Alkyne gem-Hydrogenation:\nRigorous Reassignment of Two Almost Indistinguishable Diastereomers","volume":"64","author":"Molina Betancourt","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"issue":"30","key":"2026090910092832100_cit50","doi-asserted-by":"publisher","first-page":"9943","DOI":"10.1021\/ja062469l","article-title":"On the Proof and Disproof\nof Natural Product Stereostructures: Characterization and Analysis\nof a Twenty-Eight Member Stereoisomer Library of Murisolins and Their\nMosher Ester Derivatives","volume":"128","author":"Curran","year":"2006","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"2026090910092832100_cit51","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1021\/jo7018015","article-title":"Total Synthesis\nof (\u2212)-Hennoxazole A","volume":"73","author":"Smith","year":"2008","journal-title":"J. Org. Chem."},{"issue":"6","key":"2026090910092832100_cit52","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1039\/C5CC07141K","article-title":"Same data,\ndifferent structures: diastereoisomers with substantially identical\nNMR data from nature","volume":"52","author":"Wang","year":"2016","journal-title":"Chem. Commun."},{"issue":"3","key":"2026090910092832100_cit53","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1039\/D2CB00005A","article-title":"Developing crosslinkers\nspecific for epimerization domain in NRPS initiation modules to evaluate\nmechanism","volume":"3","author":"Kim","year":"2022","journal-title":"RSC Chem. Biol."},{"issue":"14","key":"2026090910092832100_cit54","doi-asserted-by":"publisher","first-page":"3770","DOI":"10.1002\/anie.201609079","article-title":"Nonribosomal peptide synthesis principles and prospects","volume":"56","author":"Su\u0308ssmuth","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"issue":"8","key":"2026090910092832100_cit55","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.1021\/jacs.7b00278","article-title":"Mechanism and Stereochemistry\nof Polyketide Chain Elongation and Methyl Group Epimerization in Polyether\nBiosynthesis","volume":"139","author":"Xie","year":"2017","journal-title":"J. Am. Chem. Soc."},{"issue":"17","key":"2026090910092832100_cit56","doi-asserted-by":"publisher","first-page":"5455","DOI":"10.1128\/JB.181.17.5455-5460.1999","article-title":"ZmaR, a Novel\nand Widespread Antibiotic Resistance Determinant That Acetylates Zwittermicin\nA","volume":"181","author":"Stohl","year":"1999","journal-title":"J. Bacteriol."},{"issue":"1","key":"2026090910092832100_cit57","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1038\/s41467-022-29829-w","article-title":"Molecular\nbasis of antibiotic\nself-resistance in a bee larvae pathogen","volume":"13","author":"Dang","year":"2022","journal-title":"Nat.\nCommun."},{"issue":"8","key":"2026090910092832100_cit58","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.chembiol.2013.06.010","article-title":"Self Resistance\nto the Atypical Cationic Antimicrobial Peptide Edeine of Brevibacillus\nbrevis Vm4 by the N-Acetyltransferase EdeQ","volume":"20","author":"Westman","year":"2013","journal-title":"Chem. Biol."},{"issue":"1","key":"2026090910092832100_cit59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1086\/595011","article-title":"Bad bugs, no drugs: no ESKAPE! An\nupdate from the Infectious\nDiseases Society of America","volume":"48","author":"Boucher","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"2026090910092832100_cit60","volume-title":"Methods for Dilution\nAntimicrobial Susceptibility Tests for Bacteria that Grow Aerobically:\nApproved Standard","author":"Jorgensen","year":"1993"},{"key":"2026090910092832100_cit61","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14399","article-title":"Serratia marcescens\nantibiotic resistance mechanisms of an opportunistic pathogen: a literature\nreview","volume":"11","author":"Tavares-Carreon","year":"2023","journal-title":"PeerJ"},{"issue":"4","key":"2026090910092832100_cit62","doi-asserted-by":"publisher","first-page":"606","DOI":"10.7164\/antibiotics.46.606","article-title":"TAN-1057 A\u2013D,\nNew antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus taxonomy, fermentation and biological\nactivity","volume":"46","author":"Katayama","year":"1993","journal-title":"J. Antibiot."},{"issue":"46","key":"2026090910092832100_cit63","doi-asserted-by":"publisher","first-page":"5654","DOI":"10.1039\/D1CC01838H","article-title":"The antibacterial activity of peptide\ndendrimers and\npolymyxin B increases sharply above pH 7.4","volume":"57","author":"Cai","year":"2021","journal-title":"Chem. Commun."},{"issue":"4","key":"2026090910092832100_cit64","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/ph9040067","article-title":"pH Dependent Antimicrobial\nPeptides and Proteins, Their Mechanisms of Action and Potential as\nTherapeutic Agents","volume":"9","author":"Malik","year":"2016","journal-title":"Pharmaceuticals"},{"issue":"6","key":"2026090910092832100_cit65","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1086\/381972","article-title":"Clinical relevance of bacteriostatic versus bactericidal\nmechanisms of action in the treatment of Gram-positive bacterial infections","volume":"38","author":"Pankey","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"2026090910092832100_cit66","volume-title":"Methods for Determining\nBactericidal Activity of Antimicrobial Agents: Approved Guideline","author":"Barry","year":"1999"},{"issue":"12","key":"2026090910092832100_cit67","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1021\/acs.accounts.3c00183","article-title":"Structure\nElucidation of Secondary Metabolites: Current Frontiers and Lingering\nPitfalls","volume":"56","author":"DiBello","year":"2023","journal-title":"Acc. Chem. Res."},{"issue":"17","key":"2026090910092832100_cit68","doi-asserted-by":"publisher","first-page":"6578","DOI":"10.1021\/jacs.1c01729","article-title":"Structure\nRevision of the Lomaiviticins","volume":"143","author":"Kim","year":"2021","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026090910092832100_cit69","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/s42004-026-02089-1","article-title":"Application of electron diffraction to rapid\nstructural elucidation of crude reaction products","volume":"9","author":"Karothu","year":"2026","journal-title":"Commun. Chem."},{"issue":"17","key":"2026090910092832100_cit70","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202524615","article-title":"Second-Generation\nCrystalline Sponges\nEnabling Consistent Structure Analysis Under Standardized Conditions\nfor Diverse Molecules","volume":"65","author":"He","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"issue":"19","key":"2026090910092832100_cit71","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1002\/anie.201601448","article-title":"Astellifadiene: Structure\nDetermination by NMR Spectroscopy and Crystalline\nSponge Method, and Elucidation of its Biosynthesis","volume":"55","author":"Matsuda","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"issue":"12","key":"2026090910092832100_cit72","doi-asserted-by":"publisher","first-page":"714","DOI":"10.3390\/md19120714","article-title":"Structure\nRevision and Protein Tyrosine Phosphatase Inhibitory Activity of Drazepinone","volume":"19","author":"Cao","year":"2021","journal-title":"Mar. Drugs"},{"issue":"3","key":"2026090910092832100_cit73","doi-asserted-by":"publisher","first-page":"1934578X21996166","DOI":"10.1177\/1934578X21996166","article-title":"Vibrational circular dichroism absolute\nconfiguration of natural products from 2015 to 2019","volume":"16","author":"del Ri\u0301o","year":"2021","journal-title":"Nat. Prod. Commun."},{"issue":"41","key":"2026090910092832100_cit74","doi-asserted-by":"publisher","first-page":"12549","DOI":"10.1073\/pnas.1516878112","article-title":"Illuminating the\ndark matter in metabolomics","volume":"112","author":"da Silva","year":"2015","journal-title":"Proc. Natl. Acad.\nSci. U. S. A."}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c09931","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/35\/38069\/67546550\/jacs.6c09931.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/35\/38069\/67546550\/jacs.6c09931.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:28:19Z","timestamp":1788967699000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/35\/38069\/5343189\/Total-Synthesis-and-Structural-Revision-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":74,"journal-issue":{"issue":"35","published-online":{"date-parts":[[2026,8,27]]},"published-print":{"date-parts":[[2026,9,9]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c09931","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]}}}