{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:18:54Z","timestamp":1788254334140,"version":"build-2803163510"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CHE-2420332"],"award-info":[{"award-number":["CHE-2420332"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["F-0018"],"award-info":[{"award-number":["F-0018"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020425","name":"Lyda Hill Philanthropies","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100020425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Per- and polyfluoroalkyl substances (PFAS) are persistent pollutants whose environmental mobility and biological accumulation are governed by transport across phase boundaries. Although biological PFAS transport has been extensively investigated, synthetic systems capable of mediating selective PFAS transport remain underdeveloped. Here, we report a family of synthetic carriers (P1\u20137) that enable structure-dependent, directional PFAS transport across liquid membranes under mild pH gradients. Binding interactions were characterized by ultraviolet\u2013visible (UV\u2013Vis) and nuclear magnetic resonance (NMR) spectroscopic studies and supported by density functional theory (DFT) calculations. Transport efficiencies were quantified by liquid chromatography\u2013mass spectrometry (LC\u2013MS). Structural variations were found to modulate the host\u2013guest interactions, enabling selective transport of targeted PFAS from competitive aqueous mixtures with efficiencies exceeding 90%, whereas competing species remain largely untransported. Negligible transport occurs in the absence of a carrier. The practical applicability of the system was further demonstrated using lake water (Austin, TX, USA) containing ppm-level competing inorganic ions, with selective PFOS transport remaining effective at the associated ppt-level concentrations. These findings establish selective artificial PFAS transport as a tunable supramolecular-mediated process and provide a conceptual foundation for PFAS removal, separation, and potential detoxification.<\/jats:p>","DOI":"10.1021\/jacs.6c10023","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:02:12Z","timestamp":1786438932000},"page":"36022-36030","source":"Crossref","is-referenced-by-count":0,"title":["Carrier-Mediated Selective\nTransport of PFAS across\nLiquid Membranes"],"prefix":"10.1021","volume":"148","author":[{"given":"Yu-Dong","family":"Yang","sequence":"first","affiliation":[{"name":"The University of Texas at Austin , , 105 East 24th Street, Stop A5300 , , ,","place":["Austin, Texas, United States, 78712-1224"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Jin","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin , , 105 East 24th Street, Stop A5300 , , ,","place":["Austin, Texas, United States, 78712-1224"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poornenth","family":"Pushpanandan","sequence":"additional","affiliation":[{"name":"NSF Center for Aqueous Supramolecular Chemistry , , ,","place":["Salt Lake City, Utah, United States, 84112"]},{"name":"University of Utah , , , ,","place":["Salt Lake City, Utah, United States, 84112"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin , , 105 East 24th Street, Stop A5300 , , ,","place":["Austin, Texas, United States, 78712-1224"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4712-5316","authenticated-orcid":true,"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin , , 105 East 24th Street, Stop A5300 , , ,","place":["Austin, Texas, United States, 78712-1224"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Gibbs","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin , , 105 East 24th Street, Stop A5300 , , ,","place":["Austin, Texas, United States, 78712-1224"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel","family":"Youts","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin , , 105 East 24th Street, Stop A5300 , , ,","place":["Austin, Texas, United States, 78712-1224"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-5186","authenticated-orcid":true,"given":"Harekrushna","family":"Behera","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin , , 301 East Dean Keeton Street , , ,","place":["Austin, Texas, United States, 78712-1224"]},{"name":"The University of Texas at Austin , , 200 East Dean Keeton Street , , ,","place":["Austin, Texas, United States, 78712-1224"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Jogdand","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin , , 301 East Dean Keeton Street , , ,","place":["Austin, Texas, United States, 78712-1224"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Riddington","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin , , 105 East 24th Street, Stop A5300 , , ,","place":["Austin, Texas, United States, 78712-1224"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5545-3793","authenticated-orcid":true,"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin , , 301 East Dean Keeton Street , , ,","place":["Austin, Texas, United States, 78712-1224"]},{"name":"The University of Texas at Austin , , 200 East Dean Keeton Street , , ,","place":["Austin, Texas, United States, 78712-1224"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0907-8395","authenticated-orcid":true,"given":"Vale\u0301rie C.","family":"Pierre","sequence":"additional","affiliation":[{"name":"NSF Center for Aqueous Supramolecular Chemistry , , ,","place":["Salt Lake City, Utah, United States, 84112"]},{"name":"University of Utah , , , ,","place":["Salt Lake City, Utah, United States, 84112"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-1325","authenticated-orcid":true,"given":"Jonathan L.","family":"Sessler","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin , , 105 East 24th Street, Stop A5300 , , ,","place":["Austin, Texas, United States, 78712-1224"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"2026090104520464100_cit1","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1021\/acs.est.6b04806","article-title":"A Never-Ending Story\nof Per- and Polyfluoroalkyl Substances (PFASs)?","volume":"51","author":"Wang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"2026090104520464100_cit2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg9065","article-title":"Per- and Polyfluoroalkyl Substances in the Environment","volume":"375","author":"Evich","year":"2022","journal-title":"Science"},{"key":"2026090104520464100_cit3","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1002\/etc.4890","article-title":"Per- and Polyfluoroalkyl Substance\nToxicity and Human Health Review: Current State of Knowledge and Strategies\nfor Informing Future Research","volume":"40","author":"Fenton","year":"2021","journal-title":"Environ. Toxicol.\nChem."},{"key":"2026090104520464100_cit4","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1021\/es404008g","article-title":"Bioaccumulation\nof Perfluorinated Alkyl Acids: Observations\nand Models","volume":"48","author":"Ng","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"2026090104520464100_cit5","doi-asserted-by":"publisher","first-page":"12755","DOI":"10.1021\/acs.est.1c03386","article-title":"Addressing\nUrgent Questions for PFAS in the 21st Century","volume":"55","author":"Ng","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"2026090104520464100_cit6","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/s41561-024-01402-8","article-title":"Underestimated Burden of Per- and\nPolyfluoroalkyl Substances in Global Surface Waters and Groundwaters","volume":"17","author":"Grunfeld","year":"2024","journal-title":"Nat. Geosci."},{"key":"2026090104520464100_cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.118229","article-title":"Extraordinary Levels\nof Per- and Polyfluoroalkyl Substances (PFAS) in Vertebrate Animals\nat a New Mexico Desert Oasis: Multiple Pathways for Wildlife and Human\nExposure","volume":"249","author":"Witt","year":"2024","journal-title":"Environ. Res."},{"key":"2026090104520464100_cit8","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/10643389.2023.2223118","article-title":"A Critical Review on\nthe Bioaccumulation, Transportation, and Elimination of Per- and Polyfluoroalkyl\nSubstances in Human Beings","volume":"54","author":"Lu","year":"2024","journal-title":"Crit. Rev. Environ.\nSci. Technol."},{"key":"2026090104520464100_cit9","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1093\/etojnl\/vgaf172","article-title":"Per- and Poly-Fluoroalkyl\nSubstances (PFAS) and Human Health: A Review of Exposure Routes and\nPotential Toxicities across the Lifespan","volume":"44","author":"Yeoh","year":"2025","journal-title":"Environ.\nToxicol. Chem."},{"key":"2026090104520464100_cit10","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/s41370-024-00742-2","article-title":"Associations between\nPer- and Polyfluoroalkyl Substances (PFAS) and County-Level Cancer\nIncidence between 2016 and 2021 and Incident Cancer Burden Attributable\nto PFAS in Drinking Water in the United States","volume":"35","author":"Li","year":"2025","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"2026090104520464100_cit11","doi-asserted-by":"publisher","first-page":"22768","DOI":"10.1021\/jacs.5c04762","article-title":"Self-Aggregative\nRecognition and\nExtraction of Perfluorooctanesulfonate with Flexible Cationic Water-Soluble\nDeep Cavitands","volume":"147","author":"Lian","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026090104520464100_cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.129133","article-title":"Sensors for Detecting\nPer- and Polyfluoroalkyl Substances (PFAS): A Critical Review of Development\nChallenges, Current Sensors, and Commercialization Obstacles","volume":"417","author":"Menger","year":"2021","journal-title":"Chem. Eng. J."},{"key":"2026090104520464100_cit13","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1039\/D5SD00166H","article-title":"Recent Progress in\nCurrent and Emerging\nTechniques for the Detection of PFAS \u2013 the Forever Chemicals","volume":"5","author":"Chugh","year":"2026","journal-title":"Sens. Diagn."},{"key":"2026090104520464100_cit14","doi-asserted-by":"publisher","first-page":"19622","DOI":"10.1021\/jacs.5c22669","article-title":"Development of an Imprint-and-Report Sensor Array for\nDetection and Differentiation of Perfluorooctanoic Acid Precursors","volume":"148","author":"Tripp","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026090104520464100_cit15","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/nature16185","article-title":"Rapid Removal of Organic Micropollutants from Water\nby a Porous \u03b2-Cyclodextrin Polymer","volume":"529","author":"Alsbaiee","year":"2016","journal-title":"Nature"},{"key":"2026090104520464100_cit16","doi-asserted-by":"publisher","first-page":"6225","DOI":"10.1021\/jacs.3c14213","article-title":"Fluorinated Nonporous Adaptive Cages for the Efficient Removal of\nPerfluorooctanoic Acid from Aqueous Source Phases","volume":"146","author":"He","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"2026090104520464100_cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2026.126062","article-title":"Switchable\nThermoresponsive Fluorinated Hydrogels for Reversible and Efficient\nPFAS Adsorption\u2013Desorption","volume":"301","author":"Huang","year":"2026","journal-title":"Water Res."},{"key":"2026090104520464100_cit18","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202526027","article-title":"Efficient\nRemoval of Short-Chain\nPerfluoroalkyl Substances by Cavity-Directed Aggregation in a Molecular\nCage Host","volume":"65","author":"Andersson","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026090104520464100_cit19","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1126\/science.abm8868","article-title":"Low-Temperature\nMineralization of Perfluorocarboxylic Acids","volume":"377","author":"Trang","year":"2022","journal-title":"Science"},{"key":"2026090104520464100_cit20","doi-asserted-by":"publisher","first-page":"17150","DOI":"10.1021\/jacs.4c03117","article-title":"Low-Temperature Mineralization of\nFluorotelomers with Diverse Polar Head Groups","volume":"146","author":"Monsky","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"2026090104520464100_cit21","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192416397","article-title":"A Review\nof PFAS Destruction Technologies","volume":"19","author":"Meegoda","year":"2022","journal-title":"Int. J. Environ.\nRes. Public Health"},{"key":"2026090104520464100_cit22","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41586-025-08698-5","article-title":"Phosphate-Enabled Mechanochemical\nPFAS Destruction for Fluoride Reuse","volume":"640","author":"Yang","year":"2025","journal-title":"Nature"},{"key":"2026090104520464100_cit23","doi-asserted-by":"publisher","DOI":"10.1289\/EHP11885","article-title":"A State-of-the-Science\nReview of Interactions of Per- and Polyfluoroalkyl\nSubstances (PFAS) with Renal Transporters in Health and Disease: Implications\nfor Population Variability in PFAS Toxicokinetics","volume":"131","author":"Niu","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"2026090104520464100_cit24","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00204-022-03428-6","article-title":"Perfluoroalkyl Substances (PFASs)\nAre Substrates of the Renal Human Organic Anion Transporter 4 (OAT4)","volume":"97","author":"Louisse","year":"2023","journal-title":"Arch. Toxicol."},{"key":"2026090104520464100_cit25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1021\/tx200363w","article-title":"Renal Elimination\nof Perfluorocarboxylates (PFCAs)","volume":"25","author":"Han","year":"2012","journal-title":"Chem. Res.\nToxicol."},{"key":"2026090104520464100_cit26","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp8134","article-title":"Single-Molecule\nProfiling of Per- and Polyfluoroalkyl Substances by Cyclodextrin Mediated\nHost\u2013Guest Interactions within a Biological Nanopore","volume":"10","author":"Wei","year":"2024","journal-title":"Sci. Adv."},{"key":"2026090104520464100_cit27","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.chempr.2022.09.004","article-title":"Porous Adaptive\nLuminescent Metallacage for the Detection and Removal of Perfluoroalkyl\nCarboxylic Acids","volume":"9","author":"He","year":"2023","journal-title":"Chem"},{"key":"2026090104520464100_cit28","doi-asserted-by":"publisher","first-page":"7689","DOI":"10.1021\/jacs.7b02381","article-title":"\u03b2-Cyclodextrin\nPolymer Network\nSequesters Perfluorooctanoic Acid at Environmentally Relevant Concentrations","volume":"139","author":"Xiao","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"2026090104520464100_cit29","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202504880","article-title":"Selective\nRecognition and Extraction of Short-Chain Perfluoroalkyl Carboxylates\nby a Supramolecular Receptor","volume":"64","author":"Wang","year":"2025","journal-title":"Angew. Chem.,\nInt. Ed."},{"key":"2026090104520464100_cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2025.102246","article-title":"Functional Supramolecular\nHosts as Platforms for the Detection and Removal of Per- and Polyfluoroalkyl\nSubstances","volume":"8","author":"He","year":"2025","journal-title":"Matter"},{"key":"2026090104520464100_cit31","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1021\/jacs.2c09866","article-title":"Efficient Recognition\nand Removal of Persistent Organic Pollutants by a Bifunctional Molecular\nMaterial","volume":"145","author":"Chen","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"2026090104520464100_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202501245","article-title":"Readily Visualized\nPerfluorooctanoic Acid Detection\nUsing a Small Molecule Chemosensor","volume":"64","author":"Yang","year":"2025","journal-title":"Angew. Chem.,\nInt. Ed."},{"key":"2026090104520464100_cit33","doi-asserted-by":"publisher","first-page":"9994","DOI":"10.1039\/D0CC04400H","article-title":"Amethyrin-type expanded porphyrins\nthat display anti-aromatic character upon protonation","volume":"56","author":"Root","year":"2020","journal-title":"Chem. Commun."},{"key":"2026090104520464100_cit34","doi-asserted-by":"publisher","first-page":"14716","DOI":"10.1021\/acs.inorgchem.0c02343","article-title":"Effects of\nLigand Substitution on the Optical and Electrochemical Properties\nof (Pyridinedipyrrolide)zirconium Photosensitizers","volume":"59","author":"Zhang","year":"2020","journal-title":"Inorg. Chem."},{"key":"2026090104520464100_cit35","unstructured":"Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V.; Mennucci, B.; Petersson, G. A.; et al.\n          Gaussian 09, Revision A.1; Gaussian, Inc.: Wallingford, CT, 2009."},{"key":"2026090104520464100_cit36","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1039\/C7CS00159B","article-title":"Anion Transport\nand Supramolecular\nMedicinal Chemistry","volume":"46","author":"Gale","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"2026090104520464100_cit37","doi-asserted-by":"publisher","first-page":"14815","DOI":"10.1021\/acs.est.0c06212","article-title":"Facing the Challenge\nof Poly- and Perfluoroalkyl Substances in Water: Is Electrochemical\nOxidation the Answer?","volume":"54","author":"Radjenovic","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"2026090104520464100_cit38","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/s41586-024-08179-1","article-title":"Photocatalytic Low-Temperature\nDefluorination of PFASs","volume":"635","author":"Zhang","year":"2024","journal-title":"Nature"}],"container-title":["Journal of the American\nChemical Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.6c10023","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/33\/36022\/66483744\/jacs.6c10023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jacsat\/article-pdf\/148\/33\/36022\/66483744\/jacs.6c10023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:52:22Z","timestamp":1788252742000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jacsat\/article\/148\/33\/36022\/5251885\/Carrier-Mediated-Selective-Transport-of-PFAS"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":38,"journal-issue":{"issue":"33","published-online":{"date-parts":[[2026,8,11]]},"published-print":{"date-parts":[[2026,8,26]]}},"URL":"https:\/\/doi.org\/10.1021\/jacs.6c10023","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]}}}