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Herein, we report a strategy that overcomes this constraint by enabling migration of a \u03c3-alkyl palladium intermediate prior to carbon\u2013carbon bond formation via a previously inaccessible through-space alkyl-to-alkyl palladium shift. This two-component annulation of 2-bromoanilines or 2-bromophenols with allylic bromides proceeds through the formation of an alkyl\u2013Pd species that undergoes translocation across the carbon framework via engagement of a distal C(sp3)\u2013H bond. This process enables a cross-dehydrogenative bond formation at a site far from the point of initial catalyst installation and furnishes tricyclic heterocycle products from simple precursors. Our transformation displays a broad substrate scope across both coupling partners and exhibits excellent heteroatom compatibility. Mechanistic studies support a pathway involving reversible C\u2013H activation and migration driven by relief of steric congestion at the palladium center. These findings establish alkyl-to-alkyl palladium migration as a viable mode of reactivity and provide a foundation for reaction design based on catalyst translocation mechanisms.<\/jats:p>","DOI":"10.1021\/jacs.6c12509","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:03:20Z","timestamp":1788177800000},"page":"38395-38403","source":"Crossref","is-referenced-by-count":0,"title":["Alkyl-to-Alkyl\nPalladium Migration Enables Remote\nC\u2013C Bond Formation"],"prefix":"10.1021","volume":"148","author":[{"given":"Yangjin","family":"Kuang","sequence":"first","affiliation":[{"name":"New York University , , , ,","place":["New York, New York, United States, 10003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zhou","sequence":"additional","affiliation":[{"name":"New York University , , , ,","place":["New York, New York, United States, 10003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0285-9663","authenticated-orcid":true,"given":"Martin","family":"Tomanik","sequence":"additional","affiliation":[{"name":"New York University , , , ,","place":["New York, New York, United States, 10003"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026090910095909400_cit1a","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1021\/ar5004626","article-title":"Bidentate, Monoanionic\nAuxiliary-Directed Functionalization of Carbon\u2013Hydrogen Bonds","volume":"48","author":"Daugulis","year":"2015","journal-title":"Acc. 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